INT76426

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Context Info
Confidence 0.35
First Reported 1998
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 18
Total Number 20
Disease Relevance 6.84
Pain Relevance 9.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)
Anatomy Link Frequency
platelets 4
liver 3
stomach 2
bowel 2
small intestine 1
Cpox (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tail-flick 6 100.00 Very High Very High Very High
Hyperalgesia 5 100.00 Very High Very High Very High
cINOD 68 99.98 Very High Very High Very High
Opioid 9 99.80 Very High Very High Very High
aspirin 7 99.60 Very High Very High Very High
tolerance 9 99.52 Very High Very High Very High
Inflammation 28 99.04 Very High Very High Very High
Endocannabinoid 3 98.84 Very High Very High Very High
Morphine 2 98.40 Very High Very High Very High
Antinociceptive 4 97.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 5 100.00 Very High Very High Very High
Myocardial Infarction 7 99.48 Very High Very High Very High
INFLAMMATION 57 99.44 Very High Very High Very High
Bronchospasm 1 98.24 Very High Very High Very High
Injury 9 97.20 Very High Very High Very High
Nociception 7 96.68 Very High Very High Very High
Burns 10 96.64 Very High Very High Very High
Increased Venous Pressure Under Development 1 93.76 High High
Pain 16 90.80 High High
Frailty 2 88.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that not only COX-2 but also COX-1 inhibition is required for protection against inflammatory changes in liver and small intestine following burn injury.
Positive_regulation (required) of Negative_regulation (inhibition) of COX in liver associated with inflammation, burns and injury
1) Confidence 0.35 Published 2002 Journal Burns Section Abstract Doc Link 11996850 Disease Relevance 0.86 Pain Relevance 0.13
Using selective COX inhibitors, we examined whether inhibition of COX-1 or COX-2 alone is sufficient for induction of intestinal damage in rats.
Spec (whether) Positive_regulation (sufficient) of Spec (whether) Negative_regulation (inhibition) of COX
2) Confidence 0.30 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11861778 Disease Relevance 0.16 Pain Relevance 0.46
Using selective COX inhibitors, we examined whether inhibition of COX-1 or COX-2 alone is sufficient for induction of intestinal damage in rats.
Spec (whether) Positive_regulation (sufficient) of Spec (whether) Negative_regulation (inhibition) of COX
3) Confidence 0.30 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11861778 Disease Relevance 0.16 Pain Relevance 0.46
These results suggest that the intestinal ulcerogenic property of NSAID is not accounted for solely by inhibition of COX-1 and requires inhibition of COX-2 as well.
Neg (not) Positive_regulation (requires) of Negative_regulation (inhibition) of COX associated with cinod
4) Confidence 0.30 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11861778 Disease Relevance 0.07 Pain Relevance 0.34
The inhibition of COX-1 up-regulates COX-2 expression, and this may be a key to NSAID-induced intestinal damage.
Positive_regulation (up-regulates) of Negative_regulation (inhibition) of COX associated with cinod
5) Confidence 0.30 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11861778 Disease Relevance 0.07 Pain Relevance 0.34
Since the discovery of at least two isozymes of cyclooxygenase (COX), inhibition of COX-2 has been suggested to be responsible for the therapeutic effects of nonsteroidal anti-inflammatory drugs (NSAIDs).
Positive_regulation (responsible) of Negative_regulation (inhibition) of COX associated with inflammation and cinod
6) Confidence 0.30 Published 1998 Journal Neurosci. Lett. Section Abstract Doc Link 9665655 Disease Relevance 0.45 Pain Relevance 0.43
The data suggest that NSAID-induced ulcerogenesis is dependent on the amount of GA secretion derived from increased proton pump expression and requires inhibition of both COX-1 and COX-2.
Positive_regulation (requires) of Negative_regulation (inhibition) of COX associated with cinod
7) Confidence 0.28 Published 2010 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 20082628 Disease Relevance 0.26 Pain Relevance 0.14
We examined the effect of TFG extract on: (1) the response of rabbit platelets to ADP induced aggregation, (2) the contraction of mouse vas deferens induced by alpha,beta-Me-ATP (a P(2) receptor agonist; this receptor mediates the rapid phase of ADP- and ATP-evoked influx of Ca(2+) through a non-specific cation channel in platelets), (3) alpha,beta-Me-ATP induced hyperalgesia in tail flick test in male rats and (4) the specific inhibition of COX-1 and COX-2.
Positive_regulation (induced) of Negative_regulation (inhibition) of COX in platelets associated with hyperalgesia, tail-flick and agonist
8) Confidence 0.22 Published 2006 Journal J Ethnopharmacol Section Abstract Doc Link 16298092 Disease Relevance 0.16 Pain Relevance 0.80
We examined the effect of TFG extract on: (1) the response of rabbit platelets to ADP induced aggregation, (2) the contraction of mouse vas deferens induced by alpha,beta-Me-ATP (a P(2) receptor agonist; this receptor mediates the rapid phase of ADP- and ATP-evoked influx of Ca(2+) through a non-specific cation channel in platelets), (3) alpha,beta-Me-ATP induced hyperalgesia in tail flick test in male rats and (4) the specific inhibition of COX-1 and COX-2.
Positive_regulation (induced) of Negative_regulation (inhibition) of COX in platelets associated with hyperalgesia, tail-flick and agonist
9) Confidence 0.22 Published 2006 Journal J Ethnopharmacol Section Abstract Doc Link 16298092 Disease Relevance 0.16 Pain Relevance 0.80
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) induce an inhibition of cyclooxygenase (COX), an enzyme that makes prostaglandins.
Positive_regulation (induce) of Negative_regulation (inhibition) of COX associated with inflammation and cinod
10) Confidence 0.20 Published 1999 Journal Kidney Int. Section Abstract Doc Link 10571785 Disease Relevance 0.34 Pain Relevance 0.35
Selective inhibition of COX-2 significantly increased postoperative small bowel transit compared to controls (GC 2.9 +/- 0.3 vs 2.2 +/- 0.1 at 30 min, GC 2.9 +/- 0.3 vs 2.5 +/- 0.2 at 3 h, and GC 3.3 +/- 0.3 vs 2.8 +/- 0.2 at 6 h, P < 0.05).
Positive_regulation (increased) of Negative_regulation (inhibition) of COX in bowel
11) Confidence 0.19 Published 1999 Journal J. Surg. Res. Section Abstract Doc Link 10452868 Disease Relevance 0.39 Pain Relevance 0.32
In the rat stomach with functioning afferent nerves neither selective inhibition of cyclooxygenase (COX)-1 nor COX-2 is ulcerogenic and only simultaneous inhibition of both COX isoenzymes induees mucosal lesions.
Positive_regulation (induees) of Negative_regulation (inhibition) of COX in stomach
12) Confidence 0.17 Published 2001 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 11787758 Disease Relevance 0.19 Pain Relevance 0.44
The changes in our view of the importance of NSAID-induced cyclo-oxygenase (COX) inhibition on the pathogenesis and prevention of NSAID-induced gastrointestinal injury is presented.
Positive_regulation (induced) of Negative_regulation (inhibition) of COX associated with injury and cinod
13) Confidence 0.16 Published 2006 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 17132203 Disease Relevance 0.36 Pain Relevance 0.69
These data suggest that not only COX-2 but also COX-1 inhibition is required for protection against inflammatory changes in liver and small intestine following burn injury.
Positive_regulation (required) of in small intestine Negative_regulation (inhibition) of COX in liver associated with inflammation, burns and injury
14) Confidence 0.12 Published 2002 Journal Burns Section Abstract Doc Link 11996850 Disease Relevance 0.86 Pain Relevance 0.13
However, data obtained using COX inhibitors in presence of IL-1?
Positive_regulation (using) of Negative_regulation (inhibitors) of COX
15) Confidence 0.09 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731738 Disease Relevance 0 Pain Relevance 0.28
However, aspirin at a concentration sufficient for cyclooxygenase (COX)-1 inhibition did not induce gastric relaxation.
Positive_regulation (sufficient) of Negative_regulation (inhibition) of COX associated with aspirin
16) Confidence 0.06 Published 2004 Journal Drugs Exp Clin Res Section Abstract Doc Link 15700751 Disease Relevance 0.53 Pain Relevance 0.39
There are concerns that selective cyclo-oxygenase (COX)-2 inhibitors may be prothrombotic and increase the risk of myocardial infarction.
Positive_regulation (increase) of Negative_regulation (inhibitors) of COX associated with myocardial infarction
17) Confidence 0.04 Published 2002 Journal Drug Saf Section Abstract Doc Link 12241124 Disease Relevance 0.46 Pain Relevance 0.11
It has been suggested that the mechanisms of action of NSAIDs could be due to inhibition of cyclooxygenase (COX) and also to an increase in endocannabinoid concentrations.
Positive_regulation (due) of Negative_regulation (inhibition) of COX associated with endocannabinoid and cinod
18) Confidence 0.03 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17027744 Disease Relevance 0.25 Pain Relevance 0.70
The mechanism of action of these drugs is attributed to the inhibition of cyclooxygenase (COX), and, consequently, the conversion of arachidonic acid into prostaglandins.
Positive_regulation (attributed) of Negative_regulation (inhibition) of COX
19) Confidence 0.03 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11728379 Disease Relevance 0.71 Pain Relevance 0.63
Recently, our and others' studies also found that cyclooxygenase (COX) inhibitors could attenuate the opioid tolerance without enhancing morphine's antinociceptive effect.
Positive_regulation (attenuate) of Negative_regulation (inhibitors) of COX associated with tolerance, antinociceptive, opioid and morphine
20) Confidence 0.01 Published 2000 Journal Acta Anaesthesiol. Sin. Section Abstract Doc Link 11125691 Disease Relevance 0.38 Pain Relevance 2.00

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