INT76427

Context Info Confidence 0.31 First Reported 1998 Last Reported 2008 Negated 0 Speculated 3 Reported most in Abstract Documents 17 Total Number 20 Disease Relevance 6.75 Pain Relevance 7.93

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)

Anatomy Link Frequency liver 3 plasma 2 microglial cells 2 neutrophils 2 small intestine 1 Cpox (Rattus norvegicus)

Pain Link Frequency Relevance Heat cINOD 50 100.00 COX-2 inhibitor 23 100.00 COX2 9 100.00 cOX1 4 100.00 Morphine 28 99.84 Inflammatory mediators 2 99.44 Pain 8 99.40 Inflammation 22 98.82 isoflurane 8 98.68 aspirin 16 91.08

Disease Link Frequency Relevance Heat Adverse Drug Reaction 2 99.76 Pain 6 99.40 Toxicity 5 99.32 INFLAMMATION 36 99.12 Hepatic Insufficiency 2 98.20 Injury 11 97.92 Nociception 5 96.68 Pressure And Volume Under Development 2 94.72 Fever 2 94.08 Disease 7 91.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The aim of this study was to investigate the role of cyclooxygenase (COX) inhibition in intestinal motility and in the extent of tissue injury of the small intestine and liver with the use of various COX inhibitors.

Spec (investigate) Regulation (role) of Spec (investigate) Negative_regulation (inhibition) of COX in liver associated with injury

1) Confidence 0.31 Published 2002 Journal Burns Section Abstract Doc Link 11996850 Disease Relevance 0.31 Pain Relevance 0

Since the discovery of at least two isozymes of cyclooxygenase (COX), inhibition of COX-2 has been suggested to be responsible for the therapeutic effects of nonsteroidal anti-inflammatory drugs (NSAIDs).

Regulation (responsible) of Negative_regulation (inhibition) of COX associated with inflammation and cinod

2) Confidence 0.29 Published 1998 Journal Neurosci. Lett. Section Abstract Doc Link 9665655 Disease Relevance 0.45 Pain Relevance 0.43

To assess the mechanism of action of a COX-2 inhibitor, we studied the expression of COX-2 and assayed plasma levels of prostaglandins, and also compared the clinical effect of a COX-2 inhibitor with a 5-lipoxygenase (LO) inhibitor, which is responsible for another pathway of arachidonic acid metabolism.

Regulation (effect) of Negative_regulation (inhibitor) of COX in plasma associated with cox-2 inhibitor

3) Confidence 0.28 Published 1999 Journal Muscle Nerve Section Abstract Doc Link 10567084 Disease Relevance 0.34 Pain Relevance 0.51

We studied the influence of specific COX-2 inhibitors on this decrease of MAC.

Regulation (influence) of Negative_regulation (inhibitors) of COX associated with cox-2 inhibitor

4) Confidence 0.28 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 14742370 Disease Relevance 0 Pain Relevance 0.82

A synergistic effect of nonselective cyclooxygenase (COX) inhibitors on morphine-induced decrease of isoflurane minimum alveolar concentration (MAC(ISO)) has been observed in the rat.

Regulation (effect) of Negative_regulation (inhibitors) of COX associated with isoflurane and morphine

5) Confidence 0.24 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 14742370 Disease Relevance 0 Pain Relevance 0.69

The effect of alpha-MSH on reactive oxygen species (ROS) production by rat peritoneal neutrophils and the effect of cyclooxygenase (COX) inhibition were investigated using the chemiluminescence (CL) technique.

Regulation (effect) of Negative_regulation (inhibition) of COX in neutrophils

6) Confidence 0.23 Published 2004 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 15172677 Disease Relevance 0 Pain Relevance 0.07

Role of cyclooxygenase (COX)-1 and COX-2 inhibition in nonsteroidal anti-inflammatory drug-induced intestinal damage in rats: relation to various pathogenic events.

Regulation (Role) of Negative_regulation (inhibition) of COX associated with inflammation, cinod and cox1

7) Confidence 0.20 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 12438549 Disease Relevance 0.31 Pain Relevance 0.49

The changes in our view of the importance of NSAID-induced cyclo-oxygenase (COX) inhibition on the pathogenesis and prevention of NSAID-induced gastrointestinal injury is presented.

Regulation (importance) of Negative_regulation (inhibition) of COX associated with injury and cinod

8) Confidence 0.15 Published 2006 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 17132203 Disease Relevance 0.37 Pain Relevance 0.69

The aim of this study was to investigate the role of cyclooxygenase (COX) inhibition in intestinal motility and in the extent of tissue injury of the small intestine and liver with the use of various COX inhibitors.

Spec (investigate) Regulation (role) of in small intestine Spec (investigate) Negative_regulation (inhibition) of COX in liver associated with injury

9) Confidence 0.11 Published 2002 Journal Burns Section Abstract Doc Link 11996850 Disease Relevance 0.31 Pain Relevance 0

This is supported by a previous study performed in LPS-stimulated human adult microglial cells, in which selective inhibition of COX-1 was also very effective in reducing PGE2 production [62].

Regulation (effective) of Negative_regulation (inhibition) of COX in microglial cells

10) Confidence 0.08 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2100038 Disease Relevance 0.05 Pain Relevance 0

In this study, we examined the effects of various inhibitors of cyclooxygenase (COX) or NO synthase (NOS) on the acid-induced HCO3- secretion in rats and determined the enzyme isoforms responsible for this response.

Spec (examined) Regulation (effects) of Spec (examined) Negative_regulation (inhibitors) of COX

11) Confidence 0.08 Published 2002 Journal Dig. Dis. Sci. Section Abstract Doc Link 12353866 Disease Relevance 0 Pain Relevance 0.12

This review discusses: 1) how two separate catalytic processes in COX - peroxidase and prostaglandin synthase - act in an integrated fashion manner to generate prostaglandins; 2) why irreversible inactivation of COX is important constitutively and pharmacologically; 3) how cells have managed to use two closely related, almost identical enzymes in ways that discriminate their physiological versus pathological roles; 4) how investigators have used these advances to formulate and test medically important uses for old drugs (i.e. aspirin) and create new ones that still seek to achieve Hoffman's original goal.

Regulation (important) of Negative_regulation (inactivation) of COX associated with aspirin

12) Confidence 0.05 Published 2004 Journal Curr. Pharm. Des. Section Abstract Doc Link 14965321 Disease Relevance 0.26 Pain Relevance 0.35

Studies have shown that both therapeutic and side effects of NSAIDs are dependent on cyclooxygenase (COX) inhibition.

Regulation (dependent) of Negative_regulation (inhibition) of COX associated with cinod

13) Confidence 0.04 Published 2007 Journal Pharmacol Rep Section Abstract Doc Link 17652824 Disease Relevance 0.98 Pain Relevance 0.54

Such critical adverse reactions are mostly dependent on COX-1 inhibition.

Regulation (dependent) of Negative_regulation (inhibition) of COX associated with adverse drug reaction

14) Confidence 0.04 Published 2007 Journal Pharmacol Rep Section Abstract Doc Link 17652824 Disease Relevance 0.99 Pain Relevance 0.54

OBJECTIVE: To determine the effect of 3 different cyclo-oxygenase (COX) inhibitors on primary dysmenorrheic pain.

Regulation (effect) of Negative_regulation (inhibitors) of COX associated with pain

15) Confidence 0.02 Published 2008 Journal Clin J Pain Section Abstract Doc Link 18180635 Disease Relevance 0.17 Pain Relevance 0.17

Anti-inflammatory effects of NSAIDs are mediated by COX-2 inhibition, while COX-1 inhibition is responsible for gastric prostaglandin inhibition.

Regulation (responsible) of Negative_regulation (inhibition) of COX associated with inflammation and cinod

16) Confidence 0.02 Published 2005 Journal Curr. Pharm. Des. Section Abstract Doc Link 15892675 Disease Relevance 0.53 Pain Relevance 0.72

It was found that their action is centred on the inhibition of the cyclooxygenase (COX) enzyme responsible for converting arachidonic acid to prostaglandins.

Regulation (centred) of Negative_regulation (inhibition) of COX

17) Confidence 0.01 Published 2003 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 14552700 Disease Relevance 0.17 Pain Relevance 0.29

Several currently available nonsteroidal anti-inflammatory drugs (NSAIDs) have been evaluated for their relative selectivity in inhibiting the two cyclooxygenase (COX) isozymes, COX-1 and COX-2.

Regulation (selectivity) of Negative_regulation (inhibiting) of COX associated with inflammation and cinod

18) Confidence 0.01 Published 1999 Journal Scand. J. Rheumatol. Suppl. Section Abstract Doc Link 10422543 Disease Relevance 0.10 Pain Relevance 0.44

Nonspecific COX inhibition appears to be responsible for much of the toxicity of NSAIDs.

Regulation (responsible) of Negative_regulation (inhibition) of COX associated with toxicity and cinod

19) Confidence 0.01 Published 2000 Journal Am J Health Syst Pharm Section Abstract Doc Link 10674776 Disease Relevance 0.96 Pain Relevance 0.81

Role of COX inhibition in pathogenesis of NSAID-induced small intestinal damage.

Regulation (Role) of Negative_regulation (inhibition) of COX associated with cinod

20) Confidence 0.00 Published 2003 Journal J. Physiol. Pharmacol. Section Title Doc Link 15075458 Disease Relevance 0.37 Pain Relevance 0.23

General Comments

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