INT76428

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Context Info
Confidence 0.76
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 24
Total Number 26
Disease Relevance 6.09
Pain Relevance 12.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Sstr2) plasma membrane (Sstr2) cytoplasm (Sstr2)
signal transducer activity (Sstr2)
Anatomy Link Frequency
Leydig cells 5
neurons 3
pituitary 2
neuronal 1
dorsal roots 1
Sstr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 625 100.00 Very High Very High Very High
Periaqueductal grey 21 99.96 Very High Very High Very High
agonist 74 99.78 Very High Very High Very High
dexamethasone 6 99.76 Very High Very High Very High
substantia gelatinosa 9 99.68 Very High Very High Very High
nociceptor 7 99.38 Very High Very High Very High
dorsal rhizotomy 7 98.58 Very High Very High Very High
analgesia 21 98.24 Very High Very High Very High
Analgesic 7 97.76 Very High Very High Very High
Glutamate 9 97.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pituitary Cancer 26 99.98 Very High Very High Very High
Urological Neuroanatomy 21 99.96 Very High Very High Very High
Adenoma 41 98.84 Very High Very High Very High
Nociception 22 98.36 Very High Very High Very High
Targeted Disruption 23 98.24 Very High Very High Very High
Ganglion Cysts 64 96.72 Very High Very High Very High
Facial Pain 1 96.52 Very High Very High Very High
Cancer 108 93.96 High High
Apoptosis 6 91.40 High High
Peripheral Arterial Disease 9 85.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Decreased afferent responses to somatostatin receptor 2 stimulation correlated with lower expression of vagal somatostatin receptor 2 in stressed Nb-infected mice, confirming a link between molecular data and functional sequelae.
Gene_expression (expression) of somatostatin receptor 2
1) Confidence 0.76 Published 2007 Journal Gastroenterology Section Body Doc Link 17408648 Disease Relevance 0.05 Pain Relevance 0
These results suggest that functional SSTR2 receptors are expressed on the SG neurons of Vc in juvenile mice and can be a potential target for modulating orofacial pain.
Gene_expression (expressed) of SSTR2 in neurons associated with substantia gelatinosa and face pain
2) Confidence 0.73 Published 2009 Journal Brain Res. Section Abstract Doc Link 19782664 Disease Relevance 0.10 Pain Relevance 1.13
The expression of sstr2 by GnRH neurons was confirmed in the sstr2 knockout/LacZ knock-in mouse line.
Gene_expression (expression) of sstr2 in neurons associated with targeted disruption
3) Confidence 0.69 Published 2010 Journal Endocrinology Section Abstract Doc Link 20410192 Disease Relevance 0.20 Pain Relevance 0.55
Together, these studies reveal somatostatin, acting through sstr2, to be one of the most potent inhibitors of electrical excitability of male and female GnRH neurons identified thus far.
Gene_expression (acting) of sstr2 in neurons associated with somatostatin
4) Confidence 0.60 Published 2010 Journal Endocrinology Section Abstract Doc Link 20410192 Disease Relevance 0.18 Pain Relevance 0.46
GH-secreting pituitary adenomas express predominantly SST2 and SST5 receptors.
Gene_expression (express) of SST2 in pituitary associated with pituitary cancer
5) Confidence 0.53 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.43 Pain Relevance 0.36
To define the neuronal systems expressing the sst2(a) receptor in brain areas associated with analgesia, immunohistochemical co-localisation studies were carried out in the periaqueductal grey (PAG) and spinal cord using an antibody specific for the sst2(a) receptor.
Gene_expression (expressing) of sst2 in neuronal associated with periaqueductal grey, spinal cord and analgesia
6) Confidence 0.49 Published 1998 Journal Brain Res. Section Abstract Doc Link 9666064 Disease Relevance 0.43 Pain Relevance 0.85
In the PAG, sst2(a) receptor expressing neurones were found to co-express calbindin D28k (36%), the glutamate transporter EAAC-1 (25%), and GABA transporter GAT-1 ( approximately 10%).
Gene_expression (expressing) of sst2 associated with gaba, glutamate and periaqueductal grey
7) Confidence 0.49 Published 1998 Journal Brain Res. Section Abstract Doc Link 9666064 Disease Relevance 0.43 Pain Relevance 0.93
GH secreting adenomas express different somatostatin receptors, as shown for example by a recent study in which 77% expressed SSTR2, 69% SSTR1 and SSTR3, and 60% SSTR5.
Gene_expression (expressed) of SSTR2 associated with adenoma and somatostatin
8) Confidence 0.46 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.81 Pain Relevance 0.12
To further define sst2(a) receptor expressing neurones, sst2(a) receptor immunohistochemistry was combined with retrograde tracing using fluorogold.
Gene_expression (expressing) of sst2
9) Confidence 0.42 Published 1998 Journal Brain Res. Section Abstract Doc Link 9666064 Disease Relevance 0.44 Pain Relevance 0.93
In the PAG, sst2(a) receptor expressing neurones were found to co-express calbindin D28k (36%), the glutamate transporter EAAC-1 (25%), and GABA transporter GAT-1 ( approximately 10%).
Gene_expression (expressing) of sst2 associated with gaba, glutamate and periaqueductal grey
10) Confidence 0.42 Published 1998 Journal Brain Res. Section Abstract Doc Link 9666064 Disease Relevance 0.43 Pain Relevance 0.93
To further define sst2(a) receptor expressing neurones, sst2(a) receptor immunohistochemistry was combined with retrograde tracing using fluorogold.
Gene_expression (expressing) of sst2
11) Confidence 0.38 Published 1998 Journal Brain Res. Section Abstract Doc Link 9666064 Disease Relevance 0.44 Pain Relevance 0.93
Immunohistochemistry and receptor autoradiography using [125I]BIM 23027 after dorsal rhizotomy of the lumbar dorsal roots, L4 and L5, suggests that the somatostatin sst2(a) receptor is not present on primary afferent neurones.
Neg (not) Gene_expression (present) of sst2 in dorsal roots associated with dorsal rhizotomy and somatostatin
12) Confidence 0.33 Published 1998 Journal Brain Res. Section Abstract Doc Link 9666064 Disease Relevance 0.35 Pain Relevance 0.97
Identification of somatostatin sst2(a) receptor expressing neurones in central regions involved in nociception.
Gene_expression (expressing) of sst2 associated with nociception, nociceptor and somatostatin
13) Confidence 0.33 Published 1998 Journal Brain Res. Section Title Doc Link 9666064 Disease Relevance 0.41 Pain Relevance 0.95
Another example is the ectopic GFP expression in the somatostatin receptor 2 (sstr2)-EGFP BAC mouse line (unpublished observations).
Gene_expression (expression) of somatostatin receptor 2 associated with somatostatin
14) Confidence 0.29 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2519030 Disease Relevance 0.57 Pain Relevance 0.08
More recently, it was found that sst5-targeting agonists were more effective than sst2-targeting agonists in inhibiting ACTH release; this could depend on dexamethasone decreasing sst2 but not sst5 expression.
Gene_expression (expression) of sst2 associated with agonist and dexamethasone
15) Confidence 0.24 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2963160 Disease Relevance 0.25 Pain Relevance 0.63
Rat pituitary corticotrophs express multiple somatostatin receptors (sst), including sst2 and sst5,49 but treatment of cultured rat corticotrophs with native SS-14 does not result in inhibition of ACTH release.50 However, SS-14 is able to decrease ACTH release when rat pituitary cells are cultured in glucocorticoid-free media.51 Therefore, it can be hypothesized that the presence of glucocorticoids reduces the inhibitory effects of native SS and traditional SS analogs on ACTH release through the down regulation of the SS binding sites.52 A number of studies have indicated that, in the murine AtT-20 cells, sst2 and sst5 are principally involved in the regulation of ACTH release.
Gene_expression (express) of sst2 in pituitary associated with somatostatin
16) Confidence 0.24 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2963160 Disease Relevance 0.18 Pain Relevance 0.60
More recently, it was found that sst5-targeting agonists were more effective than sst2-targeting agonists in inhibiting ACTH release; this could depend on dexamethasone decreasing sst2 but not sst5 expression.
Gene_expression (effective) of sst2 associated with agonist and dexamethasone
17) Confidence 0.24 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2963160 Disease Relevance 0.23 Pain Relevance 0.65
Induction of sst2 receptor expression by testosterone might be one of the underlying molecular mechanisms responsible for the inhibition of testosterone secretion by SRIF.
Gene_expression (expression) of sst2 associated with somatostatin
18) Confidence 0.15 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC151791 Disease Relevance 0 Pain Relevance 0.27
Expression of sst2 receptor protein was studied by immunohistochemistry on tissue sections from immature pigs.
Gene_expression (Expression) of sst2
19) Confidence 0.15 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC151791 Disease Relevance 0 Pain Relevance 0
RT-PCR analysis of sst2 receptor expression
Gene_expression (expression) of sst2
20) Confidence 0.15 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC151791 Disease Relevance 0.07 Pain Relevance 0

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