INT76433

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Context Info
Confidence 0.34
First Reported 1998
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 4.27
Pain Relevance 4.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PRKG1) signal transduction (PRKG1) plasma membrane (PRKG1)
cytoplasm (PRKG1)
Anatomy Link Frequency
tail 2
neurons 1
colon 1
DRG 1
hippocampus 1
PRKG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dorsal horn neuron 40 99.28 Very High Very High Very High
Serotonin 11 99.22 Very High Very High Very High
Neurotransmitter 16 98.92 Very High Very High Very High
Pain 25 98.88 Very High Very High Very High
Hippocampus 11 98.78 Very High Very High Very High
Glutamate 16 98.60 Very High Very High Very High
hyperexcitability 9 98.60 Very High Very High Very High
nMDA receptor 32 97.52 Very High Very High Very High
Hyperalgesia 8 97.28 Very High Very High Very High
Spinal cord 75 97.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Death 64 100.00 Very High Very High Very High
Colon Cancer 12 98.92 Very High Very High Very High
Pain 29 98.88 Very High Very High Very High
Apoptosis 12 98.08 Very High Very High Very High
Hyperalgesia 10 97.28 Very High Very High Very High
Inflammatory Pain 9 96.72 Very High Very High Very High
Neuropathic Pain 28 96.56 Very High Very High Very High
INFLAMMATION 15 80.44 Quite High
Nociception 75 79.92 Quite High
Cancer 6 79.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that sulindac metabolites modulate ERK1/2 and PKG pathways independently in colon cancer cells and suggest that the full apoptotic effect of sulindac is mediated by more than one pathway.
Neg (independently) Regulation (modulate) of PKG in colon associated with colon cancer and apoptosis
1) Confidence 0.34 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16546990 Disease Relevance 0.81 Pain Relevance 0.05
Thus, the current data support a role for the cGMP-PKG pathway in the control of neurotransmitter release in vivo.
Regulation (role) of PKG associated with neurotransmitter
2) Confidence 0.21 Published 1998 Journal Brain Res. Section Abstract Doc Link 9666148 Disease Relevance 0 Pain Relevance 0.87
The purpose of this study was to determine if PKG, ERK1/2, JNK, and beta-catenin are independent targets for sulindac in vitro.
Neg (independent) Regulation (targets) of PKG
3) Confidence 0.21 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16546990 Disease Relevance 1.01 Pain Relevance 0.15
itself rather than at the level of other well documented targets of cAMP/PKA and cGMP/PKG on Rho signaling [35,36].
Regulation (targets) of PKG
4) Confidence 0.13 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.07
Evidence is presented for roles of both the cAMP-PKA and cGMP-protein kinase G (PKG) pathways in maintaining neuronal hyperexcitability and behavioral hyperalgesia in a neuropathic pain model: chronic compression of the DRG (CCD treatment).
Regulation (roles) of PKG in DRG associated with hyperalgesia, neuropathic pain and hyperexcitability
5) Confidence 0.09 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16120663 Disease Relevance 0.45 Pain Relevance 0.65
is subject to regulation by both direct prostacyclin/PKA and NO/PKG-inhibition mediated through their respective phosphorylation of Ser329 and Ser331 within the unique C-tail domain of TP?
Regulation (regulation) of PKG in tail
6) Confidence 0.06 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
It is known that several protein kinases, such as PKC, PKA, PKG, MAPK and CaMKII, affect the responses of dorsal horn neurons through phosphorylation of synaptic receptors and proteins involved in the intracellular signal transduction pathways, and the consequences of this modulation could be central sensitization, long-lasting inhibition, and/or changes in gene expression [23-31,53,54].
Regulation (affect) of PKG in neurons associated with central sensitization and dorsal horn neuron
7) Confidence 0.05 Published 2006 Journal Mol Pain Section Body Doc Link PMC1559591 Disease Relevance 0 Pain Relevance 0.53
On the other hand, the protein levels of NOS I and PKG during the pro-death phase were not affected by these pretreatments.


Neg (not) Regulation (affected) of PKG associated with death
8) Confidence 0.05 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.55 Pain Relevance 0.38
In the pond snail, serotonin transmission was markedly (up to 80%) dependent on endogenous NO acting postsynaptically through cGMP and PKG, perhaps bringing about phosphorylation of the serotonin receptor (Straub et al., 2007).
Regulation (dependent) of PKG associated with serotonin
9) Confidence 0.04 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0 Pain Relevance 0.20
The presumed target of cGMP is cGMP dependent protein kinase (PKG).
Regulation (target) of PKG
10) Confidence 0.02 Published 2005 Journal Mol Pain Section Body Doc Link PMC1310513 Disease Relevance 0.50 Pain Relevance 0.63
Previously provided pharmacological evidence demonstrates the participation of HO [2,3], NOS [14,15], sGC [7] and PKG [8,9] in at least the acute phases of formalin stimulation.
Regulation (participation) of PKG
11) Confidence 0.02 Published 2005 Journal Mol Pain Section Body Doc Link PMC1310513 Disease Relevance 0.55 Pain Relevance 0.62
TP-receptors are targets of cyclic GMP-dependent kinase (PKG) which induce desensitization by phosphorylation at Ser331 of the C-tail domain of the receptor [32]–[33].
Regulation (targets) of PKG in tail
12) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013104 Disease Relevance 0.06 Pain Relevance 0
In vitro models of synaptic plasticity in the hippocampus have suggested a role for CaMKII as a pre- and postsynaptic target of PKG.
Regulation (target) of PKG in hippocampus associated with hippocampus
13) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.34 Pain Relevance 0.41

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