INT76434

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Context Info
Confidence 0.58
First Reported 1998
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 25
Total Number 28
Disease Relevance 10.36
Pain Relevance 10.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PRKG1) signal transduction (PRKG1) plasma membrane (PRKG1)
cytoplasm (PRKG1)
Anatomy Link Frequency
spinal 3
spinal cord 3
spinal nerves 1
neurons 1
nerve 1
PRKG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Brush evoked pain 11 99.84 Very High Very High Very High
antagonist 10 99.84 Very High Very High Very High
Spinal cord 41 99.80 Very High Very High Very High
Morphine 19 99.76 Very High Very High Very High
long-term potentiation 47 99.72 Very High Very High Very High
intrathecal 21 99.68 Very High Very High Very High
qutenza 16 99.54 Very High Very High Very High
depression 31 99.46 Very High Very High Very High
Inflammation 13 99.24 Very High Very High Very High
Peripheral nerve injury 11 98.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 67 99.84 Very High Very High Very High
Depression 31 99.46 Very High Very High Very High
Nervous System Injury 102 99.36 Very High Very High Very High
Nociception 31 99.26 Very High Very High Very High
INFLAMMATION 13 99.24 Very High Very High Very High
Pain 35 98.48 Very High Very High Very High
Ganglion Cysts 57 98.30 Very High Very High Very High
Hypersensitivity 30 98.08 Very High Very High Very High
Hyperalgesia 41 97.96 Very High Very High Very High
Increased Venous Pressure Under Development 68 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SD-like events in the locust CNS were suppressed by pharmacological inhibition of the nitric oxide/cyclic guanosine monophosphate/protein kinase G (NO/cGMP/PKG) pathway and were exacerbated by its activation.
Negative_regulation (inhibition) of NO/cGMP/PKG associated with depression
1) Confidence 0.58 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19553462 Disease Relevance 1.48 Pain Relevance 0.41
Suppression of spreading depression-like events in locusts by inhibition of the NO/cGMP/PKG pathway.
Negative_regulation (inhibition) of NO/cGMP/PKG associated with depression
2) Confidence 0.42 Published 2009 Journal J. Neurosci. Section Title Doc Link 19553462 Disease Relevance 1.38 Pain Relevance 0.38
However, Serulle et al. (2007) were able show that blocking PKGII selectively using a dominant negative fragment also reduced LTP in adult mouse hippocampal slices, indicating that the mechanism may not be confined to the relatively immature circuitry of the tissue culture model.
Negative_regulation (blocking) of PKG in adult mouse associated with long-term potentiation
3) Confidence 0.41 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0.07 Pain Relevance 0.19
The effect of morphine on Zn(2+) release was also abolished by KT5823, a specific inhibitor of protein kinase G (PKG).
Negative_regulation (inhibitor) of PKG associated with morphine
4) Confidence 0.41 Published 2010 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 19966058 Disease Relevance 0 Pain Relevance 1.18
The NO donor diethylamine NONOate (DEANO), the PKG activator 8-pCPT-cGMP, and the PDE-5 inhibitor sildenafil, cause dose-dependent clitoral relaxation that is inhibited by antagonists of PKG (Rp-8-Br-cGMPS) or BK(Ca) channels (iberiotoxin).
Negative_regulation (inhibited) of PKG associated with antagonist
5) Confidence 0.38 Published 2004 Journal FASEB J. Section Abstract Doc Link 15333581 Disease Relevance 0.15 Pain Relevance 0.27
Dialysate samples were collected before and after injection of capsaicin and after infusion of inhibitors of protein kinase G (PKG; KT5823) or protein kinase A (PKA; H89).
Negative_regulation (inhibitors) of PKG associated with qutenza
6) Confidence 0.27 Published 1998 Journal Brain Res. Section Abstract Doc Link 9666148 Disease Relevance 0 Pain Relevance 0.89
The increase in aspartate and glutamate concentrations that occurs after capsaicin injection was reduced back to baseline after spinal infusion of the PKG inhibitor, KT5823.
Negative_regulation (inhibitor) of PKG in spinal associated with glutamate and qutenza
7) Confidence 0.20 Published 1998 Journal Brain Res. Section Abstract Doc Link 9666148 Disease Relevance 0 Pain Relevance 0.94
S329,331A defective in the Cicaprost-sensitive PKA (at Ser329), NO-sensitive PKG (at Ser331) or both (at Ser329,331) phosphorylation sites, as previously described by us [20,21].
Negative_regulation (defective) of PKG
8) Confidence 0.20 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
Consistent with this, KT 5823, the selective PKG inhibitor, significantly reduced U46619-induced phosphorylation of TP?
Negative_regulation (inhibitor) of PKG
9) Confidence 0.19 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.21
Intrathecal treatment with NG-L-nitro-arginine methyl ester (10-100 microg, L-NAME, a NO synthase inhibitor), 1H-(1,2,4)-oxadiazolo(4,2-a)quinoxalin-1-one (1-10 microg, ODQ, a soluble guanylyl cyclase inhibitor), KT-5823 (5-500 ng, a PKG inhibitor) and iberiotoxin (5-500 ng, a large-conductance Ca2+ -activated K+ channel blocker), but not NG-D-nitro-arginine methyl ester (100 microg, D-NAME, an inactive isomer of L-NAME), glibenclamide (12.5-50 microg, ATP-sensitive K+ channel blocker) or vehicle, significantly diminished resveratrol (300 microg)- and YC-1 (2.7 microg)-induced spinal antiallodynia.
Negative_regulation (inhibitor) of PKG in spinal associated with intrathecal
10) Confidence 0.18 Published 2006 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 16899286 Disease Relevance 0.17 Pain Relevance 0.33
Series 3 examined the potential for direct inhibition of the cGMP-dependent protein kinase to attenuate sildenafil citrate induced vasorelaxation.
Spec (examined) Negative_regulation (inhibition) of cGMP-dependent protein kinase
11) Confidence 0.15 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2680410 Disease Relevance 0 Pain Relevance 0
Series 3 examined the potential for direct inhibition of the cGMP-dependent protein kinase to attenuate sildenafil citrate induced Vasorelaxation.
Spec (examined) Negative_regulation (inhibition) of cGMP-dependent protein kinase
12) Confidence 0.15 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2680410 Disease Relevance 0.64 Pain Relevance 0
Inhibition of cyclic guanosine 5'-monophosphate-dependent protein kinase I (PKG-I) in lumbar spinal cord reduces formalin-induced hyperalgesia and PKG upregulation.
Negative_regulation (Inhibition) of PKG in spinal cord associated with hyperalgesia and spinal cord
13) Confidence 0.12 Published 2003 Journal Nitric Oxide Section Title Doc Link 12620371 Disease Relevance 0.27 Pain Relevance 0.25
These studies showed that: i) inhibitors of GC block the induction of LTP (Haley et al 1992; Zhuo et al 1994; Andreasen et al 2003); ii) analogs of cGMP produce potentiation despite the block of upstream NMDA receptors and NO release (Haley et al 1992; Arancio et al 1995); and iii) inhibitors of GC and of PKG block LTP (Arancio et al 1995, 2001).
Negative_regulation (inhibitors) of PKG associated with nmda receptor and long-term potentiation
14) Confidence 0.12 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2518390 Disease Relevance 0.27 Pain Relevance 0.34
On the other hand, the post-training inhibition of GC or PKG activity blocked memory formation (Bernabeu et al 1996).


Negative_regulation (inhibition) of PKG
15) Confidence 0.12 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2518390 Disease Relevance 1.05 Pain Relevance 0.14
We investigated the effects of inhibiting spinal protein kinases including PKC, PKA and PKG on tactile allodynia in rats with a unilateral tight ligation on L5/L6 spinal nerves (Chung model).
Spec (investigated) Negative_regulation (inhibiting) of PKG in spinal nerves associated with brush evoked pain and chung model
16) Confidence 0.11 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10624801 Disease Relevance 0.38 Pain Relevance 0.37
The adenylate cyclase inhibitor, SQ22536, the PKA antagonist, Rp-cAMPS, the guanylate cyclase inhibitor, ODQ, and the PKG inhibitor, Rp-8-pCPT-cGMPS, reduced the hyperexcitability of CCD DRG neurons.
Negative_regulation (inhibitor) of PKG in DRG associated with antagonist and hyperexcitability
17) Confidence 0.09 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16120663 Disease Relevance 0.56 Pain Relevance 0.96
The PKG inhibitor, Rp-8-bromo-cGMPS did not antagonize the antinociceptive effects of 8-bromo-cGMP but caused antinociception itself.
Negative_regulation (inhibitor) of PKG associated with antinociception and antinociceptive
18) Confidence 0.09 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12384231 Disease Relevance 0.40 Pain Relevance 0.51
Our data suggest that PKG-I activation is involved in the synaptic transmission of nociceptive stimuli in the spinal cord and that PKG-I inhibitors might be interesting novel drugs for pain treatment.
Negative_regulation (inhibitors) of PKG in spinal cord associated with nociception, pain and spinal cord
19) Confidence 0.09 Published 2003 Journal Nitric Oxide Section Abstract Doc Link 12620371 Disease Relevance 0.34 Pain Relevance 0.37
To further evaluate this pathway we assessed the effects of the PKG-inhibiting cGMP analog Rp-8-Br-cGMPS in the rat formalin assay and analyzed the regulation of PKG expression in rat lumbar spinal cord.
Negative_regulation (inhibiting) of PKG in spinal cord associated with spinal cord
20) Confidence 0.09 Published 2003 Journal Nitric Oxide Section Abstract Doc Link 12620371 Disease Relevance 0.25 Pain Relevance 0.16

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