INT76466

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Context Info
Confidence 0.45
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.94
Pain Relevance 3.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkca) endoplasmic reticulum (Prkca) enzyme binding (Prkca)
protein complex (Prkca) cytoplasm (Prkca) cytosol (Prkca)
Anatomy Link Frequency
spinal cord 2
Prkca (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 20 100.00 Very High Very High Very High
Spinal cord 2 99.16 Very High Very High Very High
cocaine 8 99.04 Very High Very High Very High
Clonidine 11 98.82 Very High Very High Very High
Morphine 21 98.56 Very High Very High Very High
midbrain 1 90.40 High High
Antinociceptive 5 86.04 High High
Intracerebroventricular 1 85.68 High High
withdrawal 1 83.96 Quite High
tail-flick 1 80.96 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 24 95.76 Very High Very High Very High
Anxiety Disorder 3 86.16 High High
Hyperalgesia 3 78.96 Quite High
Nociception 21 78.32 Quite High
Pain 6 78.28 Quite High
Coagulation Disorder 2 76.36 Quite High
Myotonic Dystrophy 22 71.96 Quite High
Stress 10 57.12 Quite High
Disease 13 50.00 Quite Low
Skin Cancer 7 19.44 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether chronic morphine or clonidine treatment alters spinal PKC activity, the present studies measured PKC activity and expression of PKC isoform proteins in spinal cord cytosol and membrane fractions.
Regulation (measured) of Gene_expression (expression) of PKC in spinal cord associated with kinase c, spinal cord, clonidine and morphine
1) Confidence 0.45 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10424770 Disease Relevance 0 Pain Relevance 2.09
We report that cocaine disrupts signal transduction in PC 12 cells by altering the expression and activity of PKC isoforms and Ca2+ levels.
Regulation (altering) of Gene_expression (expression) of PKC associated with kinase c and cocaine
2) Confidence 0.45 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9668681 Disease Relevance 0.16 Pain Relevance 0.71
However, the protein levels of PKCalpha, betaI, betaII and epsilon were not affected in the same preparation.
Neg (not) Regulation (affected) of Gene_expression (levels) of PKCalpha
3) Confidence 0.23 Published 2001 Journal Neuroscience Section Abstract Doc Link 11246146 Disease Relevance 0.07 Pain Relevance 0.95
Whole cell lysate was used to detect the expression levels of (p)PKC?
Regulation (detect) of Gene_expression (expression) of PKC
4) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668769 Disease Relevance 0 Pain Relevance 0
/PKC pathway: intracellular calcium release, sensitisation of TRPV1, and translocation of the epsilon isoform of PKC (PKC?)
Regulation (/) of Gene_expression (pathway) of PKC
5) Confidence 0.10 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2956715 Disease Relevance 0.44 Pain Relevance 0.16
It has been also shown that PKC phopshorylation regulates CUGBP1 [63].
Regulation (regulates) of Gene_expression (phopshorylation) of PKC
6) Confidence 0.05 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.27 Pain Relevance 0

General Comments

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