INT76467

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Context Info
Confidence 0.37
First Reported 1998
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 41
Total Number 42
Disease Relevance 12.88
Pain Relevance 4.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Car2) extracellular space (Car2) lyase activity (Car2)
cytoplasm (Car2)
Anatomy Link Frequency
cardiomyocytes 10
neurons 6
muscle 4
heart 4
plasma 2
Car2 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 146 100.00 Very High Very High Very High
Kinase C 26 100.00 Very High Very High Very High
cocaine 8 99.04 Very High Very High Very High
Eae 15 98.64 Very High Very High Very High
Glutamate 136 98.40 Very High Very High Very High
Ventral tegmentum 7 98.00 Very High Very High Very High
cINOD 38 96.08 Very High Very High Very High
chronic construction injury 29 95.24 Very High Very High Very High
withdrawal 2 94.44 High High
antagonist 58 94.00 High High
Disease Link Frequency Relevance Heat
Thiamine Deficiency 62 99.80 Very High Very High Very High
Hypertrophy 8 99.34 Very High Very High Very High
Myocardial Infarction 26 99.00 Very High Very High Very High
Targeted Disruption 184 98.96 Very High Very High Very High
Coronary Artery Disease 1 98.70 Very High Very High Very High
Inflammatory Pain 4 98.64 Very High Very High Very High
Obesity 509 98.08 Very High Very High Very High
Peripheral Arterial Disease 6 96.84 Very High Very High Very High
Apoptosis 65 95.92 Very High Very High Very High
Congenital Anomalies 45 95.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ca2+ sensitive CRET activities on cellular extracts and transgenic mouse tissue
Regulation (sensitive) of Gene_expression (activities) of Ca2 associated with targeted disruption
1) Confidence 0.37 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1991622 Disease Relevance 0.18 Pain Relevance 0
However, other investigators have reported that the inactivation of Ca2+-ATPase is closely related with ischemic heart disease, heart failure, and hypertrophy of cardiac muscle; thus, as the intracellular Ca2+ concentration increases, the concentration of ryanodine receptor decreases, and in some cases, down regulation has been found to be associated with the decreased expression of its mRNA.23,24
Regulation (intracellular) of Gene_expression (concentration) of Ca2 in heart associated with hypertrophy, coronary artery disease and myocardial infarction
2) Confidence 0.32 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687630 Disease Relevance 0.30 Pain Relevance 0
Schipke et al. showed that electrical stimulation of astrocytes produced Ca2+ waves that triggered Ca2+ responses in microglia in an extracellular ATPdependent manner in a slice preparation of mouse.
Regulation (triggered) of Gene_expression (responses) of Ca2 in astrocytes
3) Confidence 0.30 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096541 Disease Relevance 0.12 Pain Relevance 0.11
However, other mechanisms should not be excluded at this time such as susceptibility of myofilament Ca2+ sensitivity and altered expression of cardiac contractile proteins.
Regulation (altered) of Gene_expression (expression) of Ca2
4) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696039 Disease Relevance 1.00 Pain Relevance 0
Intracellular Ca2+ transient properties
Regulation (Intracellular) of Gene_expression (properties) of Ca2
5) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696039 Disease Relevance 0.05 Pain Relevance 0
Likewise, the ACh-induced, C3-sensitive Ca2+ sensitization of BSM contraction was significantly augmented in ?
Regulation (sensitive) of Gene_expression (sensitization) of Ca2
6) Confidence 0.21 Published 2005 Journal Respir Res Section Body Doc Link PMC545934 Disease Relevance 0.17 Pain Relevance 0
The C3 treatment alone had no significant effect on the Ca2+ responsiveness of ?
Neg (no) Regulation (effect) of Gene_expression (responsiveness) of Ca2
7) Confidence 0.21 Published 2005 Journal Respir Res Section Body Doc Link PMC545934 Disease Relevance 0 Pain Relevance 0
Addition of Ca2+ induced a concentration-dependent BSM contraction in both the sensitized control and OA-challenged groups.
Regulation (dependent) of Gene_expression (contraction) of Ca2
8) Confidence 0.21 Published 2005 Journal Respir Res Section Body Doc Link PMC545934 Disease Relevance 0 Pain Relevance 0
Measurement of the intracellular Ca2+ concentration
Regulation (intracellular) of Gene_expression (concentration) of Ca2
9) Confidence 0.20 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912119 Disease Relevance 0.10 Pain Relevance 0
Measurement of the intracellular Ca2+ concentration
Regulation (Measurement) of Gene_expression (concentration) of Ca2
10) Confidence 0.20 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912119 Disease Relevance 0.10 Pain Relevance 0
The density of the L-type Ca2+ current in ?
Regulation (density) of Gene_expression (current) of Ca2
11) Confidence 0.20 Published 2001 Journal BMC Physiol Section Abstract Doc Link PMC37314 Disease Relevance 0.10 Pain Relevance 0.03
Thus the higher Ca2+ conductance of ?
Regulation (Thus) of Gene_expression (conductance) of Ca2
12) Confidence 0.20 Published 2001 Journal BMC Physiol Section Body Doc Link PMC37314 Disease Relevance 0 Pain Relevance 0.03
We report that cocaine disrupts signal transduction in PC 12 cells by altering the expression and activity of PKC isoforms and Ca2+ levels.
Regulation (altering) of Gene_expression (expression) of Ca2 associated with kinase c and cocaine
13) Confidence 0.20 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9668681 Disease Relevance 0.16 Pain Relevance 0.71
Here we determined that calcineurin signaling is directly linked to the proper control of cardiac contractility, rhythm, and the expression of Ca2+-handling genes in the heart.
Regulation (control) of Gene_expression (expression) of Ca2 in heart
14) Confidence 0.20 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2825466 Disease Relevance 0.34 Pain Relevance 0
These results suggest that mitochondrial Ca2+ overload may contribute to ROS production induced by A?
Spec (may) Regulation (contribute) of Gene_expression (overload) of Ca2
15) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 0.31 Pain Relevance 0.19
Solutions and chemicals for Ca2+ imaging and fluorescent dye assay
Regulation (Solutions) of Gene_expression (imaging) of Ca2 associated with imagery
16) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912856 Disease Relevance 0 Pain Relevance 0.24
Cardiomyocytes from APP/PS1 mice exhibited decreased inotropic response and impaired intracellular Ca2+ homeostasis possibly due to mechanisms associated with reduced intracellular Ca2+ release, altered expression in Ca2+ regulatory proteins, reduced adrenergic function and oxidative damage.
Regulation (altered) of Gene_expression (expression) of Ca2 in Cardiomyocytes
17) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696039 Disease Relevance 1.12 Pain Relevance 0
Experimental limitations: Although our study provided a likely causal relationship
               among cardiac mechanical function, intracellular Ca2+
               homeostasis, NADPH oxidase, O2? 
Regulation (intracellular) of Gene_expression (homeostasis) of Ca2
18) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 1.22 Pain Relevance 0
Again this could reflect a change in basal intracellular Ca2+ concentration in TRPA1 positive neurons during inflammatory pain.
Regulation (change) of Gene_expression (concentration) of Ca2 in neurons associated with eae
19) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 1.04 Pain Relevance 0.53
Mechanical and intracellular Ca2+ properties of murine cardiomyocytes in FVB and ADH mice
Regulation (intracellular) of Gene_expression (properties) of Ca2 in cardiomyocytes
20) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.10 Pain Relevance 0.09

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