INT76468

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Context Info
Confidence 0.29
First Reported 1998
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 4.54
Pain Relevance 3.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Car2) extracellular space (Car2) lyase activity (Car2)
cytoplasm (Car2)
Anatomy Link Frequency
myocytes 2
nerve 2
endothelium 2
internal 2
Car2 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 58 100.00 Very High Very High Very High
Kinase C 14 100.00 Very High Very High Very High
cocaine 8 99.04 Very High Very High Very High
Calcium channel 8 98.56 Very High Very High Very High
gABA 3 98.56 Very High Very High Very High
agonist 25 97.36 Very High Very High Very High
addiction 37 96.68 Very High Very High Very High
GABAergic 4 96.36 Very High Very High Very High
Potency 14 92.64 High High
antagonist 46 87.12 High High
Disease Link Frequency Relevance Heat
Depression 58 100.00 Very High Very High Very High
Disease 319 99.36 Very High Very High Very High
Neurodegenerative Disease 43 99.12 Very High Very High Very High
Stress 50 97.64 Very High Very High Very High
Cognitive Disorder 27 96.80 Very High Very High Very High
Increased Venous Pressure Under Development 51 96.56 Very High Very High Very High
Asthma 11 93.08 High High
Airway Obstruction 1 90.96 High High
Targeted Disruption 40 89.68 High High
Coronary Artery Disease 5 89.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of tissues with calmodulin (CaM) inhibitor W7 did not affect Ca2+ increase, but markedly suppressed NO production by EFS , suggesting that increase in internal Ca2+ stimulates nNOS via a Ca2+-CaM mediated process to produce NO.
Neg (not) Regulation (affect) of Neg (not) Positive_regulation (increase) of Ca2 in internal
1) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659787 Disease Relevance 0.25 Pain Relevance 0.33
Smooth muscle contraction including airways is mainly regulated by an increase in cytosolic Ca2+ concentration in myocytes.
Regulation (regulated) of Positive_regulation (increase) of Ca2 in myocytes
2) Confidence 0.21 Published 2005 Journal Respir Res Section Body Doc Link PMC545934 Disease Relevance 0.63 Pain Relevance 0.08
Freise et al. [20] showed that the increase in Ca2+ current was not a result of changes in single channel conductance and suggested the effects were due to changes in channel open probability.
Neg (not) Regulation (result) of Positive_regulation (increase) of Ca2
3) Confidence 0.20 Published 2001 Journal BMC Physiol Section Body Doc Link PMC37314 Disease Relevance 0 Pain Relevance 0.09
Increase in cytosolic Ca2+ started at the onset of the depolarization and peaked ?
Regulation (started) of Positive_regulation (Increase) of Ca2
4) Confidence 0.20 Published 2001 Journal BMC Physiol Section Body Doc Link PMC37314 Disease Relevance 0 Pain Relevance 0.14
We report that cocaine disrupts signal transduction in PC 12 cells by altering the expression and activity of PKC isoforms and Ca2+ levels.
Regulation (altering) of Positive_regulation (activity) of Ca2 associated with kinase c and cocaine
5) Confidence 0.20 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9668681 Disease Relevance 0.16 Pain Relevance 0.71
The activation does not depend on elevated Ca2+ levels and cross-desensitizes with that produced by other TRPA1 agonists.
Neg (not) Regulation (depend) of Positive_regulation (elevated) of Ca2 associated with agonist
6) Confidence 0.18 Published 2008 Journal Channels (Austin) Section Abstract Doc Link 18971630 Disease Relevance 0.18 Pain Relevance 0.43
On the other hand, we observed that the Ca2+ requirement of LTD induction machinery was altered in the mutant mice, since 10 mM EGTA suppressed LTD strongly in the wild-type mice but only weakly in the mutant mice.
Regulation (altered) of Positive_regulation (requirement) of Ca2 associated with depression
7) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386150 Disease Relevance 0.79 Pain Relevance 0.55
Besides NO and PGI2, a third endothelium-dependent vasodilatory process has been described in both cerebral and peripheral circulations, which is dependent on an intact endothelium, extracellular Ca2+, and activation of Ca2+-dependent K+ channels and leads to a smooth muscle hyperpolarization and subsequent vasodilatation (reviewed in [177–179]).
Regulation (dependent) of Positive_regulation (activation) of Ca2 in endothelium associated with increased venous pressure under development
8) Confidence 0.12 Published 2008 Journal Cell Mol Life Sci Section Body Doc Link PMC2798969 Disease Relevance 0.17 Pain Relevance 0.04
High voltage-activated Ca2+ channels have been proposed to be another target of Dimebon [10].
Regulation (target) of Positive_regulation (activated) of Ca2
9) Confidence 0.11 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2577671 Disease Relevance 0 Pain Relevance 0.10
However, this could not be demonstrated in ex-vivo assays performed to study the effects of TRPV1 activation on K+-evoked Ca2+ entry and release of radiolabeled GABA from rat hippocampal nerve terminals [7].
Regulation (effects) of Positive_regulation (activation) of Ca2 in nerve associated with gaba
10) Confidence 0.06 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.82 Pain Relevance 0.89
The dysregulation of age-related Ca2+ and an increased
Regulation (dysregulation) of Positive_regulation (increased) of Ca2
11) Confidence 0.06 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559913 Disease Relevance 0.85 Pain Relevance 0
M) did not affect the increase of intracellular Ca2+ induced by applying KCl (50 mM).
Neg (not) Regulation (affect) of Positive_regulation (induced) of Ca2
12) Confidence 0.06 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0 Pain Relevance 0.04
One target for increased intracellular Ca2+ levels are calpains [142], cystein proteases involved in the regulation of cytoskeletal remodeling.
Regulation (target) of Positive_regulation (increased) of Ca2
13) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.70 Pain Relevance 0.07

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