INT76469

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Context Info
Confidence 0.46
First Reported 1998
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 7.90
Pain Relevance 13.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkca) endoplasmic reticulum (Prkca) enzyme binding (Prkca)
protein complex (Prkca) cytoplasm (Prkca) cytosol (Prkca)
Anatomy Link Frequency
Mouse 2
neurons 2
spinal cord 2
IB4 2
proximal 2
Prkca (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 445 100.00 Very High Very High Very High
Morphine 310 100.00 Very High Very High Very High
agonist 47 100.00 Very High Very High Very High
Neuropathic pain 42 99.92 Very High Very High Very High
spinal dorsal horn 36 99.92 Very High Very High Very High
Kappa opioid receptor 7 98.98 Very High Very High Very High
Analgesic 69 98.68 Very High Very High Very High
cocaine 8 98.56 Very High Very High Very High
Spinal cord 94 98.44 Very High Very High Very High
tolerance 43 98.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Virus Diseases 94 99.94 Very High Very High Very High
Neuropathic Pain 48 99.92 Very High Very High Very High
Targeted Disruption 32 97.84 Very High Very High Very High
Nervous System Injury 67 97.52 Very High Very High Very High
Injury 220 96.92 Very High Very High Very High
Hyperalgesia 57 95.44 Very High Very High Very High
Thrombosis 38 94.96 High High
Pain 57 94.80 High High
Insulin Resistance 12 94.24 High High
Recurrence 1 94.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For the in vitro studies, the expression and activity of protein kinase C (PKC) isoforms and Ca2+ levels were examined following the incubation of PC 12 cells with cocaine.
Spec (examined) Positive_regulation (following) of Spec (examined) Gene_expression (expression) of PKC associated with kinase c and cocaine
1) Confidence 0.46 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9668681 Disease Relevance 0.12 Pain Relevance 0.78
Under these conditions, the levels of membrane-bound phosphorylated-PKC in the limbic forebrain was clearly up-regulated by intermittent morphine treatment.
Positive_regulation (up-regulated) of Gene_expression (levels) of phosphorylated-PKC in forebrain associated with kinase c and morphine
2) Confidence 0.41 Published 2002 Journal Neuroscience Section Abstract Doc Link 11955717 Disease Relevance 0 Pain Relevance 1.21
How could BDV P interfere with PKC-dependent phosphorylation in neurons?
Positive_regulation (interfere) of Gene_expression (interfere) of PKC in neurons associated with virus diseases and kinase c
3) Confidence 0.40 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.59 Pain Relevance 0.62
Western blotting analysis showed that chronic DAMGO treatment increased the levels of PKCgamma, but not PKCalpha, PKCbetaI, and PKCbetaII isoforms, in spinal cord membranes.
Positive_regulation (increased) of Gene_expression (levels) of PKCalpha in spinal cord associated with spinal cord
4) Confidence 0.36 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11356858 Disease Relevance 0 Pain Relevance 0.88
Involvement of kappa opioid receptors in the inhibition of receptor desensitization and PKC activation induced by repeated morphine treatment.
Positive_regulation (induced) of Gene_expression (activation) of PKC associated with kappa opioid receptor and morphine
5) Confidence 0.35 Published 2008 Journal J. Pharm. Pharmacol. Section Title Doc Link 18718122 Disease Relevance 0.09 Pain Relevance 2.07
In the present study, we observed increased expression of PKC?
Positive_regulation (increased) of Gene_expression (expression) of PKC
6) Confidence 0.32 Published 2005 Journal Mol Pain Section Body Doc Link PMC1175856 Disease Relevance 1.23 Pain Relevance 1.48
Increased expression of PKC?
Positive_regulation (Increased) of Gene_expression (expression) of PKC
7) Confidence 0.32 Published 2005 Journal Mol Pain Section Body Doc Link PMC1175856 Disease Relevance 1.22 Pain Relevance 1.47
also leads to enhanced secretion, calcium signaling, and phosphatidylserine exposure, the absence of PKC?
Positive_regulation (leads) of Neg (absence) Gene_expression (absence) of PKC associated with kinase c
8) Confidence 0.29 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906332 Disease Relevance 0.32 Pain Relevance 0.59
In conclusion, the PKC/MAPK pathway leading to TNF-?
Positive_regulation (leading) of Gene_expression (pathway) of PKC associated with kinase c
9) Confidence 0.26 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440772 Disease Relevance 0.18 Pain Relevance 0.09
Mouse RPCs cultured on SNW and LNW nanowire scaffolds demonstrated evidence of differentiation including increased expression of PKC and recoverin.
Positive_regulation (increased) of Gene_expression (expression) of PKC in Mouse
10) Confidence 0.24 Published 2008 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2802414 Disease Relevance 0 Pain Relevance 0
Increased expression of PKC?
Positive_regulation (Increased) of Gene_expression (expression) of PKC
11) Confidence 0.21 Published 2005 Journal Mol Pain Section Body Doc Link PMC1175856 Disease Relevance 0.98 Pain Relevance 1.23
In agreement with AKT phosphorylation data, we have observed that PKC?
Positive_regulation (observed) of Gene_expression (observed) of PKC
12) Confidence 0.20 Published 2008 Journal Diabetes Section Body Doc Link PMC2494684 Disease Relevance 0.94 Pain Relevance 0
In a recent study (Bajo et al., 2008) we demonstrated that PKC?
Positive_regulation (demonstrated) of Gene_expression (demonstrated) of PKC
13) Confidence 0.19 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.46 Pain Relevance 0.57
In response to morphine, NMDAR-nNOS generated zinc recruits PKC?
Positive_regulation (response) of Gene_expression (generated) of PKC associated with kinase c and morphine
14) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.86 Pain Relevance 1.60
On the other hand, the temperature threshold for TRPV1 activation was not changed upon treatment with a mixture of FSK, IBMX and dbcAMP in HEK293 cells expressing TRPV1 (40.8 ± 0.8°C, n = 4), suggesting different actions on TRPV1 by PKA and PKC.
Positive_regulation (activation) of Gene_expression (expressing) of PKC
15) Confidence 0.15 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0 Pain Relevance 0.20
is PKC-inducible when overexpressed in mouse keratinocytes, and is highly induced in PKC transgenic skin [38].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of PKC-inducible in skin associated with targeted disruption
16) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668769 Disease Relevance 0.63 Pain Relevance 0.16
We have shown that the IGF-1-mediated increase in VEGF isoforms using the proximal splice site is inhibited by blocking PKC and SRPK1/2, and that this can be overcome by the use of a PKC inhibitor or mimicked by a PKC agonist or overexpression of SRPK1.
Positive_regulation (overexpression) of Gene_expression (overexpression) of PKC in proximal associated with agonist
17) Confidence 0.13 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0.05
Double staining for IB4, on coverslips previously processed for PKC?
Positive_regulation (for) of Gene_expression (processed) of PKC in IB4
18) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0 Pain Relevance 0.16
The permeability of the connexons can be regulated through many mechanisms including changes in [Ca2+], pH and phosphorylation by several protein kinases [258,259], including PKC?
Positive_regulation (several) of Gene_expression (several) of PKC associated with kinase c
19) Confidence 0.07 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.28 Pain Relevance 0.20

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