INT76501

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Context Info
Confidence 0.41
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 19
Disease Relevance 8.51
Pain Relevance 3.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Selp) nucleolus (Selp) nucleus (Selp)
cytoplasm (Selp)
Anatomy Link Frequency
leukocyte 5
platelet 4
thymus 3
endothelial cells 1
erythrocytes 1
Selp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 231 97.00 Very High Very High Very High
Angina 39 96.72 Very High Very High Very High
Potency 1 94.88 High High
Pain 5 89.84 High High
anesthesia 4 88.48 High High
cytokine 36 86.64 High High
chemokine 2 86.56 High High
medulla 18 86.00 High High
agonist 1 84.80 Quite High
Bile 11 83.80 Quite High
Disease Link Frequency Relevance Heat
Heart Rate Under Development 3 99.52 Very High Very High Very High
Myocardial Infarction 38 99.32 Very High Very High Very High
Adhesions 56 98.44 Very High Very High Very High
Nicotine Addiction 10 98.06 Very High Very High Very High
INFLAMMATION 286 97.00 Very High Very High Very High
Cv General 3 Under Development 38 96.72 Very High Very High Very High
Sickle Cell Anemia 10 96.44 Very High Very High Very High
Apoptosis 186 93.36 High High
Congenital Anomalies 1 91.88 High High
Sepsis 1 88.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies of the possible interaction of erythrocytes with P-selectin revealed that either P-selectin blocking monoclonal antibodies or sialyl Lewis tetrasaccharide inhibits the enhanced adherence of normal and sickle cells to thrombin-treated endothelial cells.
P-selectin Binding (interaction) of in endothelial cells
1) Confidence 0.41 Published 2001 Journal Blood Section Abstract Doc Link 11535535 Disease Relevance 0.42 Pain Relevance 0.08
Herein the first evidence is presented for the binding of normal or sickle erythrocytes to P-selectin.
P-selectin Binding (binding) of in erythrocytes
2) Confidence 0.41 Published 2001 Journal Blood Section Abstract Doc Link 11535535 Disease Relevance 0.34 Pain Relevance 0.15
Thus the superficial gastric and duodenal mucosal microcirculations have a much lower density of ICAM-1 and P-selectin and less leukocyte-endothelial interactions than occurs in the deeper layers of the gut wall even during stimulated upregulation with endotoxin.
P-selectin Binding (interactions) of in leukocyte
3) Confidence 0.35 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16020654 Disease Relevance 0.18 Pain Relevance 0
P-selectin expression was quantified as a binding index for platelet P-selectin (the percentage of positive platelets multiplied by the mean fluorescence of positive platelets).
P-selectin Binding (binding) of in platelets
4) Confidence 0.34 Published 2007 Journal Ther Apher Dial Section Abstract Doc Link 17661830 Disease Relevance 0.25 Pain Relevance 0.09
An interaction between these two cell types has been demonstrated by the different authors in the past.24–26 Among others, P-selectin seems to be one of the most important adhesion molecules, which links the inflammatory and procoagulatory cascades and has the potency to activate leukocytes and platelets as the cellular elements of either pathway.18,19,25,26 Besides their adherence to endothelial cells, activated platelets form stable aggregates with leukocytes.
P-selectin Binding (interaction) of in leukocytes associated with inflammation, adhesions and potency
5) Confidence 0.24 Published 2007 Journal J Gastrointest Surg Section Body Doc Link PMC1852387 Disease Relevance 0.70 Pain Relevance 0.19
B, P-selectin, Bax, Bcl-2, and Caspase-3 protein expression of thymus under light microscope,
P-selectin Binding (thymus) of in thymus
6) Confidence 0.20 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234334 Disease Relevance 0.25 Pain Relevance 0.20
B, P-selectin, Bax, and Bcl-2 in thymus was negative
P-selectin Binding (negative) of in thymus
7) Confidence 0.20 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234334 Disease Relevance 0.54 Pain Relevance 0.18
B, P-selectin, Bax, Bcl-2, and Caspase-3 protein expression of thymus under light microscope,
P-selectin Binding (microscope) of in thymus
8) Confidence 0.20 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234334 Disease Relevance 0.31 Pain Relevance 0.20
Such data indicate that soluble P-selectin is associated with platelet activation and the therapeutical procedure improves the thrombogenic state in the coronary circulation.
P-selectin Binding (associated) of in platelet
9) Confidence 0.17 Published 1999 Journal J Cardiol Section Abstract Doc Link 10354952 Disease Relevance 0.31 Pain Relevance 0.31
To verify the binding specificity for ICAM-1, P-selectin, iNOS and IL-1?
P-selectin Binding (binding) of
10) Confidence 0.15 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 0 Pain Relevance 0
To verify the binding specificity for ICAM-1, P-selectin, iNOS and IL-1?
P-selectin Binding (specificity) of
11) Confidence 0.15 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 0 Pain Relevance 0
In contrast, 8 days following ligation, positive staining for ICAM-1 and P-selectin, were found in the gingivomucosal tissues from ligature operated rats (Figure 5c and 5e respectively), mainly localized in the inflammatory cells in derma and around the vessels respectively.
P-selectin Binding (ligation) of in vessels associated with inflammation
12) Confidence 0.14 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 0.44 Pain Relevance 0.25
Sections were incubated overnight with 1) purified goat polyclonal antibody directed towards P-selectin which reacts with mice; or 2) with purified hamster anti-mouse ICAM-1 (CD54) (1:500 in PBS, w/v) (DBA, Milan, Italy) or 3) with anti-nitrotyrosine rabbit polyclonal antibody (1:500 in PBS, v/v) or 4) with anti-iNOS antibody (1:500 in PBS, v/v) or 5) with anti-IL-1?
P-selectin Binding (reacts) of
13) Confidence 0.14 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 0.05 Pain Relevance 0
P-selectin in platelets and endothelial cells mediates adhesive interactions between platelet, leukocyte and endothelium to form thrombi.
P-selectin Binding (interactions) of in platelet
14) Confidence 0.11 Published 1998 Journal Int. J. Cardiol. Section Abstract Doc Link 9672405 Disease Relevance 0.84 Pain Relevance 0.37
P-selectin is expressed upon platelet activation and binds the P-selectin glycoprotein ligand-1 on leukocytes [18].
P-selectin Binding (binds) of in leukocytes
15) Confidence 0.06 Published 2009 Journal J Thromb Thrombolysis Section Body Doc Link PMC2766044 Disease Relevance 0.39 Pain Relevance 0.20
The percentage binding of anti-P-selectin, CD63, and PAC-1 antibody to platelets, and the levels of PDMPs (per 10(4) platelets) were higher in the patients with AMI than in those with stable pectoris angina (P-selectin, 23.1% +/- 2.1% vs. 10.3% +/- 1.2%, p < 0.001; CD63, 24.6% +/- 3.3% vs. 11.2% +/- 3.1%, p < 0.01; PAC-1, 14.1% +/- 1.7% vs. 9.3% +/- 2.1%, p < 0.05; PDMPs, 613 +/- 71 vs. 413 +/- 55, p < 0.01).
anti-P-selectin Binding (binding) of in platelets associated with heart rate under development, angina and myocardial infarction
16) Confidence 0.04 Published 2002 Journal Clin. Appl. Thromb. Hemost. Section Abstract Doc Link 12361207 Disease Relevance 1.03 Pain Relevance 0.33
P-selectin in platelets and endothelial cells mediates adhesive interactions between platelet, leukocyte and endothelium to form thrombi.
P-selectin Binding (interactions) of in leukocyte
17) Confidence 0.04 Published 1998 Journal Int. J. Cardiol. Section Abstract Doc Link 9672405 Disease Relevance 0.84 Pain Relevance 0.37
P-selectin in platelets and endothelial cells mediates adhesive interactions between platelet, leukocyte and endothelium to form thrombi.
P-selectin Binding (interactions) of in endothelium
18) Confidence 0.04 Published 1998 Journal Int. J. Cardiol. Section Abstract Doc Link 9672405 Disease Relevance 0.84 Pain Relevance 0.37
Methods: In a case-control study we enrolled 20 healthy cigarette smokers and 20 nonsmokers, and measured TPO and C-reactive protein (CRP), as well as platelet-leukocyte binding and P-selectin expression.
P-selectin Binding (binding) of in leukocyte associated with nicotine addiction
19) Confidence 0.03 Published 2010 Journal Atherosclerosis Section Abstract Doc Link 20006331 Disease Relevance 0.78 Pain Relevance 0.13

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