INT76505

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Context Info
Confidence 0.21
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.48
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Homer1) cytoplasm (Homer1)
Anatomy Link Frequency
B cell 2
neurons 2
brain 2
Homer1 (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 7 99.08 Very High Very High Very High
corticosteroid 1 89.20 High High
Morphine 6 75.00 Quite High
antagonist 2 62.16 Quite High
opioid receptor 2 52.64 Quite High
Thalamus 1 44.88 Quite Low
Central grey 1 40.16 Quite Low
parabrachial 1 36.72 Quite Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 6 98.32 Very High Very High Very High
Lymphatic System Cancer 12 87.64 High High
Infection 29 33.92 Quite Low
Epstein-barr Virus 15 5.00 Very Low Very Low Very Low
Sarcoma 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Viral Infection 2 5.00 Very Low Very Low Very Low
Sleep Disorders 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Lymphoproliferative Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of immediate early gene (nur77) mRNA increased in paraventricular nucleus neurons after stress exposure in virgin and lactating, but not pregnant, mice.
Positive_regulation (increased) of Transcription (expression) of immediate early gene in neurons associated with stress
1) Confidence 0.21 Published 2003 Journal Endocrinology Section Abstract Doc Link 12960085 Disease Relevance 0.39 Pain Relevance 0.13
Although M2 is completely dispensable for MHV68 replication in permissive cell lines [18],[21], we next assessed whether it might play a B cell-specific role in activating transcription from the immediate-early gene 50 promoter which encodes the essential lytic switch protein RTA.
Positive_regulation (activating) of Transcription (transcription) of immediate-early gene in B cell
2) Confidence 0.10 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777334 Disease Relevance 0.09 Pain Relevance 0
However, it has been shown that opioids can activate specific signaling pathways and induce immediate early gene (IEG) transcription in brain.
Positive_regulation (induce) of Transcription (transcription) of immediate early gene in brain associated with opioid
3) Confidence 0.03 Published 1998 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 9673793 Disease Relevance 0 Pain Relevance 0.46

General Comments

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