INT76531

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Context Info
Confidence 0.72
First Reported 1998
Last Reported 2010
Negated 3
Speculated 3
Reported most in Abstract
Documents 62
Total Number 66
Disease Relevance 23.69
Pain Relevance 34.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) plasma membrane (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
neurons 12
DRG 6
spinal cord 4
thoracic 2
CoAO 2
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 623 100.00 Very High Very High Very High
B1 receptor 198 100.00 Very High Very High Very High
Pain 129 100.00 Very High Very High Very High
Spinal cord 109 100.00 Very High Very High Very High
substance P 63 100.00 Very High Very High Very High
nociceptor 47 100.00 Very High Very High Very High
vanilloid receptor subtype 1 23 100.00 Very High Very High Very High
ASIC 10 100.00 Very High Very High Very High
TRP channel 2 100.00 Very High Very High Very High
Nerve growth factor 144 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acidosis 4 99.86 Very High Very High Very High
Neuropathic Pain 137 99.68 Very High Very High Very High
INFLAMMATION 80 99.60 Very High Very High Very High
Ganglion Cysts 169 99.44 Very High Very High Very High
Coronary Artery Disease 20 99.44 Very High Very High Very High
Inflammatory Pain 7 99.30 Very High Very High Very High
Hypersensitivity 22 98.56 Very High Very High Very High
Pain 108 98.16 Very High Very High Very High
Stress 22 97.76 Very High Very High Very High
Injury 33 97.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin sensitivity is associated with the expression of the vanilloid (capsaicin) receptor (VR1) mRNA in adult rat sensory ganglia.
Transcription (expression) of VR1 in ganglia associated with qutenza
1) Confidence 0.72 Published 1998 Journal Neurosci. Lett. Section Title Doc Link 9708861 Disease Relevance 0.29 Pain Relevance 0.82
In contrast, TRPV1 transcription in amygdala, prefrontal cortex, and thalamus was not affected by TMJ inflammation and estradiol.
Transcription (transcription) of TRPV1 in TMJ associated with snapping jaw, inflammation, thalamus and amygdala
2) Confidence 0.72 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20592193 Disease Relevance 1.54 Pain Relevance 1.65
Reverse-transcription polymerase chain reaction was used to measure mRNA expression of TRPV1 in these neurons after laser capture microdissection.
Transcription (expression) of TRPV1 in neurons
3) Confidence 0.72 Published 2007 Journal Gastroenterology Section Body Doc Link 17698068 Disease Relevance 0.18 Pain Relevance 0
Retrograde labelled and microdissected dorsal root ganglia sensory neurons were used to evaluate TRPV1 gene transcription.
Transcription (transcription) of TRPV1 gene in dorsal root ganglia
4) Confidence 0.72 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19523146 Disease Relevance 0.95 Pain Relevance 0.36
Post-WA TRPV1 transcription and expression was not higher in MS than NH rats.
Transcription (transcription) of TRPV1
5) Confidence 0.72 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19523146 Disease Relevance 0.92 Pain Relevance 0.39
Another point of departure between TRPV1 expression in the DRG and the brain is that, neonatal capsaicin treatment in rats reduces expression of TRPV1 mRNA in the DRG, but not in the brain [16].
Transcription (expression) of TRPV1 in brain associated with qutenza
6) Confidence 0.72 Published 2006 Journal Mol Pain Section Body Doc Link PMC1647269 Disease Relevance 0.14 Pain Relevance 0.42
The most prominent expression of TRPV1 mRNA and receptors is in the DRG with expression much less concentrated in supraspinal structures.
Transcription (expression) of TRPV1
7) Confidence 0.72 Published 2006 Journal Mol Pain Section Body Doc Link PMC1647269 Disease Relevance 0.59 Pain Relevance 0.56
The results showed that 1 could up-regulate the mRNA expression levels of TRPV1 at both 37 and 39 degrees C, and its calcium-mediating function was significantly increased at 39 degrees C, all of which could not be blocked by pretreatment of the neuronal cells with ruthenium red, a general transient receptor potential (TRP) blocker, indicating that the action of 1 was achieved through a non-TRPA1 channel pathway.
Transcription (expression) of TRPV1 in neuronal
8) Confidence 0.72 Published 2010 Journal J Asian Nat Prod Res Section Abstract Doc Link 20390747 Disease Relevance 0.24 Pain Relevance 0
Only SP mRNA was increased significantly in T4 and brainstem during CoAO, while SCS decreased the mRNA levels of SP, NK-1 and TRPV1 significantly in T4 and the brainstem.
Transcription (levels) of TRPV1 in CoAO associated with medulla and spinal-cord stimulation
9) Confidence 0.71 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17714867 Disease Relevance 0.39 Pain Relevance 0.75
Sustained (30 min to 4 h) exposure of cultured neurons to TNFalpha evoked a twofold increase in mRNA transcript (P<0.05) and protein levels (P<0.01) of transient potential receptor vanilloid type 1 (TRPV1).
Transcription (transcript) of TRPV1 in neurons
10) Confidence 0.69 Published 2008 Journal Neuroscience Section Abstract Doc Link 18582539 Disease Relevance 0.50 Pain Relevance 0.79
The elevation of the levels of VR1 mRNA and VR1 protein induced by exogenous galanin implicated that VR1 may be involved in the mechanisms of SP release evoked by capsaicin.


Transcription (levels) of VR1
11) Confidence 0.69 Published 2008 Journal Neuro Endocrinol. Lett. Section Body Doc Link 19112407 Disease Relevance 0.06 Pain Relevance 0
The elevation of the levels of VR1 mRNA and VR1 protein induced by exogenous galanin implicated that VR1 may be involved in the mechanisms of SP release evoked by capsaicin.


Transcription (levels) of VR1 protein
12) Confidence 0.69 Published 2008 Journal Neuro Endocrinol. Lett. Section Body Doc Link 19112407 Disease Relevance 0.06 Pain Relevance 0
RESULTS: The amount of VR1 mRNA and VR1 protein expression and capsaicin-evoked SP release in cultured DRG neurons increased significantly after incubation with exogenous galanin compared with control DRG neurons at the same time point, whereas the amount of SP mRNA and basal SP release were not affected after incubation with exogenous galanin.
Transcription (mRNA) of VR1 in neurons
13) Confidence 0.69 Published 2008 Journal Neuro Endocrinol. Lett. Section Body Doc Link 19112407 Disease Relevance 0.08 Pain Relevance 0
We studied the expression of SP, neurokinin-1 (NK-1) receptor, and transient receptor potential vanilloid type 1 (TRPV1) mRNA in the rat spinal cord at thoracic 4 (T4), cervical 2 (C2) and caudal brain stem by RT-PCR during intermittent occlusion of the left anterior descending coronary artery (CoAO), during sustained SCS by itself at the C2 spinal segment, and during sustained SCS plus intermittent CoAO.
Transcription (expression) of TRPV1 in thoracic associated with spinal-cord stimulation and spinal cord
14) Confidence 0.68 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17714867 Disease Relevance 0.32 Pain Relevance 0.59
Differential expression of the mRNA for the vanilloid receptor subtype 1 in cells of the adult rat dorsal root and nodose ganglia and its downregulation by axotomy.
Transcription (expression) of vanilloid receptor subtype 1 in dorsal root associated with vanilloid receptor subtype 1 and neuropeptide
15) Confidence 0.68 Published 1999 Journal J. Neurosci. Section Title Doc Link 10024368 Disease Relevance 0.15 Pain Relevance 0.98
Vanilloid receptor subtype 1 mRNA was widely distributed in the brain, with a marked level in the hypothalamus and cerebellum, but not in the spinal cord.
Neg (not) Transcription (distributed) of Vanilloid receptor subtype 1 mRNA in hypothalamus associated with vanilloid receptor subtype 1 and spinal cord
16) Confidence 0.68 Published 1998 Journal Neuroreport Section Abstract Doc Link 9674591 Disease Relevance 0 Pain Relevance 1.04
All above cultured samples were processed for detecting expression of mRNA for SP, CGRP and vanilloid receptor 1 (VR1) of DRG neurons by RT-PCR, and VR1 protein expression by Western blot.
Transcription (expression) of vanilloid receptor 1 in DRG
17) Confidence 0.68 Published 2006 Journal Neuro Endocrinol. Lett. Section Body Doc Link 17187013 Disease Relevance 0.09 Pain Relevance 0
All above cultured samples were processed for detecting expression of mRNA for SP, CGRP and vanilloid receptor 1 (VR1) of DRG neurons by RT-PCR, and VR1 protein expression by Western blot.
Transcription (expression) of VR1 in DRG
18) Confidence 0.68 Published 2006 Journal Neuro Endocrinol. Lett. Section Body Doc Link 17187013 Disease Relevance 0.09 Pain Relevance 0
Expression of SP mRNA and vanilloid receptor 1 (VR1) mRNA was determined by RT-PCR.
Spec (determined) Transcription (Expression) of vanilloid receptor 1 associated with substance p
19) Confidence 0.67 Published 2010 Journal Pharmazie Section Abstract Doc Link 20383941 Disease Relevance 0.55 Pain Relevance 1.87
Expression of SP mRNA and vanilloid receptor 1 (VR1) mRNA was determined by RT-PCR.
Spec (determined) Transcription (Expression) of VR1 associated with substance p
20) Confidence 0.67 Published 2010 Journal Pharmazie Section Abstract Doc Link 20383941 Disease Relevance 0.55 Pain Relevance 1.87

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