INT76532

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Context Info
Confidence 0.37
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 9.32
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos3) Golgi apparatus (Nos3) cytoplasm (Nos3)
signal transduction (Nos3) oxidoreductase activity (Nos3) nucleolus (Nos3)
Anatomy Link Frequency
cardiomyocyte 2
plasma 1
macrophages 1
neutrophils 1
Nos3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 77 99.16 Very High Very High Very High
Pain 90 97.36 Very High Very High Very High
Tetrahydrobiopterin 26 96.48 Very High Very High Very High
Kinase C 6 94.44 High High
Antinociceptive 6 85.32 High High
Angina 5 77.28 Quite High
Bioavailability 11 75.12 Quite High
potassium channel 4 70.92 Quite High
Neuronal excitability 2 66.68 Quite High
allodynia 4 62.72 Quite High
Disease Link Frequency Relevance Heat
Stress 123 99.98 Very High Very High Very High
Hypertension 203 99.76 Very High Very High Very High
Myocardial Infarction 42 99.40 Very High Very High Very High
INFLAMMATION 82 99.16 Very High Very High Very High
Diabetes Mellitus 260 98.28 Very High Very High Very High
Pain 90 97.36 Very High Very High Very High
Nociception 12 95.60 Very High Very High Very High
Injury 46 92.92 High High
Hyperlipidemia 9 92.36 High High
Disease 92 92.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endothelial nitric oxide synthase gene is positively associated with essential hypertension.
Endothelial nitric oxide synthase Binding (associated) of associated with hypertension
1) Confidence 0.37 Published 1998 Journal Hypertension Section Title Doc Link 9674630 Disease Relevance 0.91 Pain Relevance 0.08
Estrogen has been shown to influence the expression and activity of endothelial nitric oxide synthase (eNOS) which is associated with increased S-nitrosothiol production.
eNOS Binding (associated) of
2) Confidence 0.33 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2982841 Disease Relevance 0.32 Pain Relevance 0
Estrogen has been shown to influence the expression and activity of endothelial nitric oxide synthase (eNOS) which is associated with increased S-nitrosothiol production.
endothelial nitric oxide synthase Binding (associated) of
3) Confidence 0.33 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2982841 Disease Relevance 0.33 Pain Relevance 0
It is known that nNOS and eNOS, though found primarily within the nervous system and endothelial tissue respectively, are also found in other tissues, whereas iNOS is expressed in various cell types, such as macrophages and neutrophils [6].
eNOS Binding (found) of in neutrophils
4) Confidence 0.31 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949722 Disease Relevance 1.04 Pain Relevance 0.56
If increased GSNO-R activity in female mice can protect against the adverse affects of nitrosative stress associated with eNOS activation, chronic inflammation, chronic hypoxemia and high flow states, why are female humans at higher risk for the development of PH from a variety of causes than are males?
eNOS Binding (associated) of associated with stress, inflammation and hypertension
5) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2982841 Disease Relevance 1.17 Pain Relevance 0.13
We show a strong independent association of the eNOS genotype with myocardial infarction in patients with T2DM and which is emphasized in females.
eNOS Binding (association) of associated with diabetes mellitus and myocardial infarction
6) Confidence 0.26 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2636751 Disease Relevance 0.89 Pain Relevance 0.07
Data from our lab
               revealed that leptin directly suppresses cardiomyocyte contraction and intracellular
                   Ca2+ handling through mechanism(s) related to endothelial
               nitric oxide synthase (eNOS), superoxide (O2?)
               
eNOS Binding (endothelial) of in cardiomyocyte
7) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 1.13 Pain Relevance 0
In the heart eNOS is associated with the caveolae [29],[57] and nNOS is normally in the sarcoplasmic reticulum (SR) in close association with ryanodine receptors [29],[58] and XOR [37],[38]. nNOS-derived NO mediates cardiomyocyte contraction through its effects on the SR Ca+2 cycle that is central to excitation-contraction coupling and modulation of ryanodine receptor function [21], [30]–[32],[59].
eNOS Binding (associated) of in cardiomyocyte
8) Confidence 0.22 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2680977 Disease Relevance 0.07 Pain Relevance 0
Uncoupling of eNOS enzyme results in the production of damaging O2' adding to the oxidative stress within the arterial vessel wall.
eNOS Binding (Uncoupling) of associated with stress
9) Confidence 0.15 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 0.85 Pain Relevance 0.17
In addition, endogenous analogues such as asymmetric dimethyl-L-arginine (ADMA) can compete with L-arginine for its specific membrane transporter and also directly for access to eNOS, where ADMA acts as an inhibitor.
eNOS Binding (access) of
10) Confidence 0.14 Published 2010 Journal Curr Hypertens Rep Section Body Doc Link PMC2910890 Disease Relevance 0.25 Pain Relevance 0.12
Since 1992, ADMA has been recognized as an endogenous inhibitor of eNOS, and in vitro experiments demonstrated that the NO production is inhibited by ADMA in a concentration-dependent manner (Vallance et al 1992).
eNOS Binding (recognized) of
11) Confidence 0.13 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464748 Disease Relevance 0.61 Pain Relevance 0.18
It is known that nNOS and eNOS, though found primarily within the nervous system and endothelial tissue respectively, are also found in other tissues, whereas iNOS is expressed in various cell types, such as macrophages and neutrophils [6].
eNOS Binding (found) of in macrophages
12) Confidence 0.10 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949722 Disease Relevance 1.04 Pain Relevance 0.56
Caveolae have a specialized structure and function that distinguish them from general plasma membranes, lipid rafts, or clathrin-coated pits.78 In particular, caveolae contain high concentrations of signaling molecules including G-proteins, receptor tyrosine kinases, non-receptor tyrosine kinases, and endothelial nitric oxide synthase (eNOS).79 These molecules interact with caveolae via protein-protein interactions with a 20-amino acid region of Cav-1 called the “caveolin-1 scaffolding domain” (CSD).80 Through CSD-mediated activities, caveolae act as compartments to organize signaling events from the cell surface to the inside of the cell and between specific intracellular organelles.81
eNOS Binding (interact) of in plasma
13) Confidence 0.08 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004586 Disease Relevance 0.71 Pain Relevance 0

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