INT76551

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Context Info
Confidence 0.45
First Reported 1998
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.60
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 1
brain 1
kidney 1
Ang (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 10 100.00 Very High Very High Very High
antagonist 6 100.00 Very High Very High Very High
Central nervous system 36 98.88 Very High Very High Very High
Hippocampus 5 79.92 Quite High
Inflammation 19 76.00 Quite High
Neurotransmitter 3 22.32 Low Low
chemokine 25 5.00 Very Low Very Low Very Low
Glutamate 18 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
potassium channel 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 28 100.00 Very High Very High Very High
Hypertension 17 98.08 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 83 96.72 Very High Very High Very High
Toxicity 4 96.24 Very High Very High Very High
Diuresis 3 88.32 High High
Infection 34 83.84 Quite High
INFLAMMATION 26 76.00 Quite High
Disease 12 68.64 Quite High
Retinoblastoma 1 64.72 Quite High
Stress 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, pretreatment with [7-D-Ala]-Ang 1-7 (5 nmol/kg/min) did not affect the pressor effect of Ang II, but abolished the renal response to Ang 1-7.
Neg (not) Regulation (affect) of Ang
1) Confidence 0.45 Published 1998 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 9676737 Disease Relevance 0.08 Pain Relevance 0.04
Losartan (10 mg/kg, i.v.) blocked the pressor effect of exogenous Ang II (100 pmol/kg/min, i.a.), but did not significantly affect the renal response to Ang 1-7.
Neg (not) Regulation (affect) of Ang
2) Confidence 0.45 Published 1998 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 9676737 Disease Relevance 0.09 Pain Relevance 0.04
Therefore we tested the effect of Ang II AT1-receptor antagonist losartan and [7-D-Ala]-Ang 1-7 on the renal response to exogenous Ang 1-7 in standard renal-clearance experiments in the anesthetized rat.
Regulation (effect) of Ang associated with antagonist
3) Confidence 0.45 Published 1998 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 9676737 Disease Relevance 0.09 Pain Relevance 0.05
Collectively, these data suggest that androgens modulate renal and systemic vascular responsiveness to ANG II, which may contribute to androgen-induced facilitation of NZGH rat hypertension.
Regulation (modulate) of ANG associated with hypertension
4) Confidence 0.35 Published 2006 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 16469840 Disease Relevance 0.58 Pain Relevance 0.06
The CNS relies heavily on plasticity, hence, the disruption of ANG and its molecular regulation could yield devastating consequences for circuits and brain regions assaulted by HIV-induced toxicity.
Regulation (regulation) of ANG in brain associated with toxicity, acquired immune deficiency syndrome or hiv infection, central nervous system and neurodegenerative disease
5) Confidence 0.23 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 1.38 Pain Relevance 0.13
Effects of anesthesia on plasma and kidney ANG II levels in normotensive and ANG II-dependent hypertensive rats.
Regulation (Effects) of ANG in kidney associated with anesthesia and hypertension
6) Confidence 0.23 Published 2006 Journal Kidney Blood Press. Res. Section Title Doc Link 16651849 Disease Relevance 0.19 Pain Relevance 0.29
Effects of anesthesia on plasma and kidney ANG II levels in normotensive and ANG II-dependent hypertensive rats.
Regulation (Effects) of ANG in plasma associated with anesthesia and hypertension
7) Confidence 0.08 Published 2006 Journal Kidney Blood Press. Res. Section Title Doc Link 16651849 Disease Relevance 0.19 Pain Relevance 0.29

General Comments

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