INT76551

Context Info Confidence 0.45 First Reported 1998 Last Reported 2010 Negated 2 Speculated 0 Reported most in Abstract Documents 7 Total Number 7 Disease Relevance 2.60 Pain Relevance 0.90

Anatomy Link Frequency plasma 1 brain 1 kidney 1 Ang (Rattus norvegicus)

Pain Link Frequency Relevance Heat anesthesia 10 100.00 antagonist 6 100.00 Central nervous system 36 98.88 Hippocampus 5 79.92 Inflammation 19 76.00 Neurotransmitter 3 22.32 chemokine 25 5.00 Glutamate 18 5.00 Inflammatory response 5 5.00 potassium channel 4 5.00

Disease Link Frequency Relevance Heat Neurodegenerative Disease 28 100.00 Hypertension 17 98.08 Acquired Immune Deficiency Syndrome Or Hiv Infection 83 96.72 Toxicity 4 96.24 Diuresis 3 88.32 Infection 34 83.84 INFLAMMATION 26 76.00 Disease 12 68.64 Retinoblastoma 1 64.72 Stress 14 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Conversely, pretreatment with [7-D-Ala]-Ang 1-7 (5 nmol/kg/min) did not affect the pressor effect of Ang II, but abolished the renal response to Ang 1-7.

Neg (not) Regulation (affect) of Ang

1) Confidence 0.45 Published 1998 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 9676737 Disease Relevance 0.08 Pain Relevance 0.04

Losartan (10 mg/kg, i.v.) blocked the pressor effect of exogenous Ang II (100 pmol/kg/min, i.a.), but did not significantly affect the renal response to Ang 1-7.

Neg (not) Regulation (affect) of Ang

2) Confidence 0.45 Published 1998 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 9676737 Disease Relevance 0.09 Pain Relevance 0.04

Therefore we tested the effect of Ang II AT1-receptor antagonist losartan and [7-D-Ala]-Ang 1-7 on the renal response to exogenous Ang 1-7 in standard renal-clearance experiments in the anesthetized rat.

Regulation (effect) of Ang associated with antagonist

3) Confidence 0.45 Published 1998 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 9676737 Disease Relevance 0.09 Pain Relevance 0.05

Collectively, these data suggest that androgens modulate renal and systemic vascular responsiveness to ANG II, which may contribute to androgen-induced facilitation of NZGH rat hypertension.

Regulation (modulate) of ANG associated with hypertension

4) Confidence 0.35 Published 2006 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 16469840 Disease Relevance 0.58 Pain Relevance 0.06

The CNS relies heavily on plasticity, hence, the disruption of ANG and its molecular regulation could yield devastating consequences for circuits and brain regions assaulted by HIV-induced toxicity.

Regulation (regulation) of ANG in brain associated with toxicity, acquired immune deficiency syndrome or hiv infection, central nervous system and neurodegenerative disease

5) Confidence 0.23 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 1.38 Pain Relevance 0.13

Effects of anesthesia on plasma and kidney ANG II levels in normotensive and ANG II-dependent hypertensive rats.

Regulation (Effects) of ANG in kidney associated with anesthesia and hypertension

6) Confidence 0.23 Published 2006 Journal Kidney Blood Press. Res. Section Title Doc Link 16651849 Disease Relevance 0.19 Pain Relevance 0.29

Effects of anesthesia on plasma and kidney ANG II levels in normotensive and ANG II-dependent hypertensive rats.

Regulation (Effects) of ANG in plasma associated with anesthesia and hypertension

7) Confidence 0.08 Published 2006 Journal Kidney Blood Press. Res. Section Title Doc Link 16651849 Disease Relevance 0.19 Pain Relevance 0.29

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