INT76573

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Context Info
Confidence 0.58
First Reported 1998
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 26
Total Number 27
Disease Relevance 24.36
Pain Relevance 9.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Vcam1) aging (Vcam1) cell adhesion (Vcam1)
Anatomy Link Frequency
plasma 4
Synovial fluid 1
articular 1
blood 1
coronary artery 1
Vcam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 368 100.00 Very High Very High Very High
Osteoarthritis 18 100.00 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 33 99.56 Very High Very High Very High
Angina 45 99.04 Very High Very High Very High
cytokine 100 98.64 Very High Very High Very High
Inflammatory mediators 4 98.22 Very High Very High Very High
Neuritis 13 97.48 Very High Very High Very High
Pain score 4 97.48 Very High Very High Very High
Inflammation 193 97.12 Very High Very High Very High
Sciatic nerve 3 96.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 376 100.00 Very High Very High Very High
Adhesions 223 100.00 Very High Very High Very High
Cancer 12 100.00 Very High Very High Very High
Necrosis 11 100.00 Very High Very High Very High
Osteoarthritis 10 100.00 Very High Very High Very High
Disease 169 99.56 Very High Very High Very High
Hyperlipidemia 8 99.28 Very High Very High Very High
Systemic Sclerosis 1 99.24 Very High Very High Very High
Cv General 3 Under Development 38 99.04 Very High Very High Very High
Apoptosis 4 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The reduction of sVCAM-1 levels observed in our transfused SCD patients offers insight into the mechanism of the protective effect of transfusion against ACS and APE and possibly stroke.
Negative_regulation (reduction) of sVCAM-1 associated with sickle cell anemia, stroke and acute chest syndrome
1) Confidence 0.58 Published 2004 Journal Am. J. Hematol. Section Abstract Doc Link 15114598 Disease Relevance 1.31 Pain Relevance 0.11
It is reported that vitamin E, an antioxidant, downregulates sVCAM-1 in patients with hyperlipidemia (30).
Negative_regulation (downregulates) of sVCAM-1 associated with hyperlipidemia
2) Confidence 0.43 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1513153 Disease Relevance 1.26 Pain Relevance 0.51
We speculate that the reduction of sVCAM-1 might be one of the reasons for the improving arthritic scores in this study.
Negative_regulation (reduction) of sVCAM-1 associated with arthritis
3) Confidence 0.43 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1513153 Disease Relevance 0.97 Pain Relevance 0.20
Therefore, we speculate that the antioxidant effect of KBG might contribute to the downregulation of VCAM-1.
Negative_regulation (downregulation) of VCAM-1
4) Confidence 0.43 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1513153 Disease Relevance 1.20 Pain Relevance 0.44
Blockade of signaling via the very late antigen (VLA-4) and its counterligand vascular cell adhesion molecule-1 (VCAM-1) causes increased T cell apoptosis in experimental autoimmune neuritis.
Negative_regulation (Blockade) of VCAM-1 in T cell associated with experimental autoimmune neuritis, apoptosis, neuritis and adhesions
5) Confidence 0.42 Published 2002 Journal Acta Neuropathol. Section Title Doc Link 11810178 Disease Relevance 0.73 Pain Relevance 0.22
Although troponin T and high-sensitivity C-reactive protein were found to have prognostic value, blood levels of soluble vascular cell adhesion molecule-1 were not predictive of an increased risk of major cardiac events during 6-month follow-up.
Neg (not) Negative_regulation (predictive) of vascular cell adhesion molecule-1 in blood associated with adhesions
6) Confidence 0.40 Published 2005 Journal Am. J. Cardiol. Section Abstract Doc Link 16054462 Disease Relevance 0.85 Pain Relevance 0.32
Blockade of VCAM-1 also significantly ameliorated the disease course and diminished T-cell infiltration in sciatic nerve, but to a lesser degree.
Negative_regulation (Blockade) of VCAM-1 in sciatic nerve associated with sciatic nerve and disease
7) Confidence 0.40 Published 1998 Journal Brain Section Abstract Doc Link 9679778 Disease Relevance 1.48 Pain Relevance 0.96
The decreased ICAM-1 and VCAM-1 levels after intra-articular HA injection may help to explain the anti-inflammatory effects of HA therapy in knee OA.
Negative_regulation (decreased) of VCAM-1 in knee associated with inflammation and osteoarthritis
8) Confidence 0.37 Published 2004 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 15487709 Disease Relevance 0.92 Pain Relevance 0.42
Synovial fluid levels of both ICAM-1 and VCAM-1 were significantly reduced at weeks 1 to 3, compared to the baseline values.
Negative_regulation (reduced) of VCAM-1 in Synovial fluid
9) Confidence 0.37 Published 2004 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 15487709 Disease Relevance 0.79 Pain Relevance 0.32
The plasma level of sVCAM-1 is higher in RA patients than in osteoarthritis patients (13) and decreases by a reduction in disease activity (13,14).
Negative_regulation (decreases) of sVCAM-1 in plasma associated with rheumatoid arthritis, disease and osteoarthritis
10) Confidence 0.32 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1513153 Disease Relevance 1.42 Pain Relevance 0.67
1) were unchanged, but sVCAM-1 was decreased significantly by 12 week KBG administration (857.1 ± 51.5 versus 744.6 ± 47.3 ng ml?
Negative_regulation (decreased) of sVCAM-1
11) Confidence 0.32 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1513153 Disease Relevance 0.94 Pain Relevance 0.31
Among adhesion molecules, only sVCAM-1 decreased significantly.
Negative_regulation (decreased) of sVCAM-1 associated with adhesions
12) Confidence 0.32 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Abstract Doc Link PMC1513153 Disease Relevance 1.74 Pain Relevance 0.43
The results obtained in the present study suggest that KBG does not possess particular anti-inflammatory or immunomodulating effects but that it has a beneficial effect on articular symptoms and a protective effect against endothelial activation through the reduction of VCAM-1, and it may thereby contribute to the prevention of the progression of cardiovascular disorders in RA patients.
Negative_regulation (reduction) of VCAM-1 in articular associated with inflammation and rheumatoid arthritis
13) Confidence 0.32 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1513153 Disease Relevance 0.92 Pain Relevance 0.25
In this study, KBG did not decrease the plasma levels of sE-selectin and sICAM-1, but it reduced sVCAM-1, one of the markers of vascular endothelial activation.
Negative_regulation (reduced) of sVCAM-1 in plasma
14) Confidence 0.32 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1513153 Disease Relevance 1.45 Pain Relevance 0.67
In this study, we show that down-regulation of VCAM-1 by the chemotherapeutic agent etoposide (VP-16) is associated with altered cellular localization of NF-kappaB.
Negative_regulation (down-regulation) of VCAM-1
15) Confidence 0.26 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11322928 Disease Relevance 0.09 Pain Relevance 0
We demonstrated that VCAM-1 was diminished at the transcriptional level following treatment of stromal cells with VP-16, without alteration of VCAM-1 stability.
Negative_regulation (diminished) of VCAM-1 in stromal cells
16) Confidence 0.19 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11322928 Disease Relevance 0.09 Pain Relevance 0
In conclusion, determination of serum VCAM-1, E-selectin and P-selectin levels seems more useful for detecting coronary plaque destabilization.
Negative_regulation (determination) of serum VCAM-1 in plaque
17) Confidence 0.19 Published 2004 Journal Int. J. Cardiol. Section Abstract Doc Link 15262039 Disease Relevance 1.37 Pain Relevance 0.92
However, the sICAM-1 and sVCAM-1 levels decreased significantly in Group IA after tirofiban infusion.
Negative_regulation (decreased) of sVCAM-1
18) Confidence 0.18 Published 2004 Journal Thromb J Section Abstract Doc Link PMC406420 Disease Relevance 0.84 Pain Relevance 0.13
In addition, VCAM-1 levels were sharply decreased after the PTCA procedure.
Negative_regulation (decreased) of VCAM-1 associated with percutaneous transluminal coronary angioplasty
19) Confidence 0.17 Published 2003 Journal Heart Vessels Section Abstract Doc Link 14520483 Disease Relevance 1.40 Pain Relevance 1.26
RESULTS: (1) The clinical symptoms as frequency and persistent time of angina pectoris in the treated group were bettered significantly after treatment and the dosage of nitroglycerin used decreased (all P < 0.01), showing significant difference when compared with those in the control group (P < 0.05). (2) The effective rates on UAP symptoms and ECG in the treated group were 86.7% and 76.7% respectively, which were significantly higher than those in the control group (70.0% and 63.3%, P < 0.05). (3) Laboratory examination showed in the control group, changes only displayed in the decrease of vWF and ET and increase of NO (all P < 0.05), while in the treated group, plasma levels of vWF, ET, sVCAM-1 and sICAM-1 after treatment significantly decreased and were lower than those in the control group (P < 0.01), but NO elevated significantly and was higher than that in the control group (P < 0.01).
Negative_regulation (decreased) of sVCAM-1 in plasma
20) Confidence 0.14 Published 2009 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Body Doc Link 19338157 Disease Relevance 0 Pain Relevance 0

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