INT76581

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Context Info
Confidence 0.45
First Reported 1998
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 7.49
Pain Relevance 4.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOS1) oxidoreductase activity (NOS1) cytoskeleton (NOS1)
cytoplasm (NOS1)
Anatomy Link Frequency
nerve 4
neuronal 2
liver 2
brain 2
NOS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuronal nitric oxide synthase 7 100.00 Very High Very High Very High
Morphine 12 99.84 Very High Very High Very High
Hyperalgesia 12 99.48 Very High Very High Very High
analgesia 5 99.48 Very High Very High Very High
tolerance 8 99.04 Very High Very High Very High
headache 2 99.00 Very High Very High Very High
Stimulus evoked pain 6 98.56 Very High Very High Very High
addiction 8 98.48 Very High Very High Very High
Thermal hyperalgesia 11 98.44 Very High Very High Very High
Inflammation 29 95.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 146 99.84 Very High Very High Very High
Hyperalgesia 23 99.48 Very High Very High Very High
Hypersensitivity 63 99.32 Very High Very High Very High
Headache 1 99.00 Very High Very High Very High
Muscular Dystrophy 5 98.60 Very High Very High Very High
Pain 47 98.56 Very High Very High Very High
Synovitis 2 98.16 Very High Very High Very High
Targeted Disruption 49 97.96 Very High Very High Very High
Pressure And Volume Under Development 33 96.56 Very High Very High Very High
Diarrhoea 2 96.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of inhibition of nitric oxide synthase (NOS) on hindpaw hyperalgesia (assessed using mechanical and thermal noxious stimuli) and oedema formation following intraplantar injection of carrageenan (150 microl, 2% w v(-1)) in the rat was determined.
Regulation (effect) of Negative_regulation (inhibition) of NOS associated with pressure and volume under development and hyperalgesia
1) Confidence 0.45 Published 1998 Journal Neuropharmacology Section Abstract Doc Link 9680257 Disease Relevance 0.33 Pain Relevance 0.21
Effects of selective inhibitors of neuronal nitric oxide synthase on carrageenan-induced mechanical and thermal hyperalgesia.
Regulation (Effects) of Negative_regulation (inhibitors) of nitric oxide synthase in neuronal associated with thermal hyperalgesia and neuronal nitric oxide synthase
2) Confidence 0.45 Published 1998 Journal Neuropharmacology Section Title Doc Link 9680257 Disease Relevance 0.59 Pain Relevance 0.42
The effect of inhibition of nitric oxide synthase (NOS) on hindpaw hyperalgesia (assessed using mechanical and thermal noxious stimuli) and oedema formation following intraplantar injection of carrageenan (150 microl, 2% w v(-1)) in the rat was determined.
Regulation (effect) of Negative_regulation (inhibition) of nitric oxide synthase associated with pressure and volume under development and hyperalgesia
3) Confidence 0.45 Published 1998 Journal Neuropharmacology Section Abstract Doc Link 9680257 Disease Relevance 0.33 Pain Relevance 0.21
The effect of e-, i-, and n-nitric oxide synthase inhibition on colonic motility in normal and muscular dystrophy (mdx) mice.
Regulation (effect) of Negative_regulation (inhibition) of n-nitric oxide synthase associated with muscular dystrophy
4) Confidence 0.43 Published 2004 Journal Jpn. J. Physiol. Section Title Doc Link 15760488 Disease Relevance 0.57 Pain Relevance 0.07
Effect of NO donors and NOS inhibitors on histamine-stimulated gastric acid secretion
Regulation (Effect) of Neg (NO) Negative_regulation (inhibitors) of NOS
5) Confidence 0.35 Published 2004 Journal BMC Gastroenterol Section Body Doc Link PMC514546 Disease Relevance 0 Pain Relevance 0
Furthermore, when a nonselective NOS inhibitor or a selective iNOS inhibitor was added, the synovitis was improved but the glycosaminoglycan loss was enhanced.
Regulation (nonselective) of Negative_regulation (inhibitor) of NOS associated with synovitis
6) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582805 Disease Relevance 0.66 Pain Relevance 0.24
Effect of cyclooxygenase and nitric oxide synthase inhibitors on streptozotocin-induced hyperalgesia in rats.
Regulation (Effect) of Negative_regulation (inhibitors) of nitric oxide synthase associated with hyperalgesia
7) Confidence 0.15 Published 2008 Journal Pharmacology Section Title Doc Link 17989504 Disease Relevance 0.36 Pain Relevance 0.40
Effect of inhibition of nitric oxide synthase on chronic tension-type headache: a randomised crossover trial.
Regulation (Effect) of Negative_regulation (inhibition) of nitric oxide synthase associated with headache
8) Confidence 0.11 Published 1999 Journal Lancet Section Title Doc Link 9929022 Disease Relevance 0.27 Pain Relevance 0.36
Effects of NOS inhibitor on TiO2 particles and C60-induced genotoxicity in MEF cells
Regulation (Effects) of Negative_regulation (inhibitor) of NOS
9) Confidence 0.10 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2650674 Disease Relevance 0 Pain Relevance 0
Comparison of the effects of specific and nonspecific inhibition of nitric oxide synthase on morphine analgesia, tolerance and dependence in mice.
Regulation (effects) of Negative_regulation (inhibition) of nitric oxide synthase associated with addiction, tolerance, analgesia and morphine
10) Confidence 0.08 Published 2003 Journal Life Sci. Section Title Doc Link 12597993 Disease Relevance 0.43 Pain Relevance 1.82
Though ADC-derived agmatine is also a competititve inhibitor of the NOS isoforms in macrophages and irreversibly inhibits nNOS and down-regulate iNOS in brain [36, 37].
Regulation (regulate) of Negative_regulation (inhibitor) of NOS in brain
11) Confidence 0.05 Published 2008 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570548 Disease Relevance 0 Pain Relevance 0.04
Effect of systemic administration of a nonspecific NOS inhibitor on nerve injury-induced mechanical hypersensitivity
Regulation (Effect) of Negative_regulation (inhibitor) of NOS in nerve associated with nervous system injury and hypersensitivity
12) Confidence 0.04 Published 2007 Journal Mol Pain Section Body Doc Link PMC2089056 Disease Relevance 1.67 Pain Relevance 0.28
We examined the effect of systemic inhibition of NOS on nerve injury-induced mechanical pain hypersensitivity in WT mice.
Spec (examined) Regulation (effect) of Spec (examined) Negative_regulation (inhibition) of NOS in nerve associated with nervous system injury, hypersensitivity and stimulus evoked pain
13) Confidence 0.04 Published 2007 Journal Mol Pain Section Body Doc Link PMC2089056 Disease Relevance 1.66 Pain Relevance 0.28
Multiple studies using nonspecific NOS inhibitors revealed that diminishing NO production resulted in normalization of the peripheral vascular vasodilatation.[16] Ferguson et al demonstrated that the selective inhibition of iNOS causes peripheral vasoconstriction in patients with cirrhosis but not in healthy-matched controls, suggesting the contribution of NOS in the regulation of peripheral vascular tone and the hyperdynamic circulation of end stage liver disease.[17] Other studies favor eNOS as the leading source of the vascular NO overproduction in the splanchnic arterial circulation.[18–19]
Regulation (using) of Negative_regulation (inhibitors) of NOS in liver associated with cirrhosis, end stage liver disease and increased venous pressure under development
14) Confidence 0.03 Published 2010 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC3003209 Disease Relevance 0.61 Pain Relevance 0.04
Effect of nitric oxidase synthase (NOS) inhibitor on CCh response
Regulation (Effect) of Negative_regulation (inhibitor) of NOS
15) Confidence 0.03 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2894799 Disease Relevance 0 Pain Relevance 0.03

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