INT76597

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.63
First Reported 1998
Last Reported 2008
Negated 4
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.51
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ghsr) signal transducer activity (Ghsr)
Anatomy Link Frequency
pituitary 2
Ghsr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 39 65.72 Quite High
anesthesia 2 25.00 Low Low
Tetrahydrobiopterin 16 22.80 Low Low
Inflammation 31 5.00 Very Low Very Low Very Low
Nerve growth factor 28 5.00 Very Low Very Low Very Low
cytokine 26 5.00 Very Low Very Low Very Low
agonist 22 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 17 5.00 Very Low Very Low Very Low
substance P 16 5.00 Very Low Very Low Very Low
diabetic neuropathy 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 365 98.88 Very High Very High Very High
Thyroid Disease 4 91.12 High High
Stress 216 80.48 Quite High
Cardiovascular Disease 40 5.00 Very Low Very Low Very Low
Myocardial Infarction 36 5.00 Very Low Very Low Very Low
Hyperglycemia 32 5.00 Very Low Very Low Very Low
INFLAMMATION 32 5.00 Very Low Very Low Very Low
Diabetes Complications 24 5.00 Very Low Very Low Very Low
Targeted Disruption 22 5.00 Very Low Very Low Very Low
Cancer 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased PRL response could reflect an increase in GH secretagogue receptor expression that was observed in the arcuate and ventromedial nuclei of E2-treated rats.
Positive_regulation (increase) of Gene_expression (expression) of GH secretagogue receptor
1) Confidence 0.63 Published 1998 Journal Endocrinology Section Abstract Doc Link 9681512 Disease Relevance 0 Pain Relevance 0
We have now studied GHRP-6-induced GH and PRL release and their regulation by estrogen (E2) in anesthetized male and female rats and in GH-deficient dwarf (dw/dw) rats that maintain high pituitary PRL stores and show elevated hypothalamic GH secretagogue receptor expression.
Positive_regulation (elevated) of Gene_expression (expression) of GH secretagogue receptor in pituitary
2) Confidence 0.63 Published 1998 Journal Endocrinology Section Abstract Doc Link 9681512 Disease Relevance 0 Pain Relevance 0
GHS-R expression is also high in fetal and neonatal life, decreases postnatally and increases again just before puberty to decrease again later (413).
Positive_regulation (increases) of Gene_expression (expression) of GHS-R
3) Confidence 0.16 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.17 Pain Relevance 0.03
Mekinova et al. demonstrated that supplementation of streptozotocin (STZ) diabetic rats with vitamins C, E, and beta-carotene for 8 weeks produced a significant reduction of TBARS levels, GHS, and GHS-Px, an increase in Cu-SOD, and no change in catalase activity in kidneys [42].
Positive_regulation (increase) of Neg (no) Gene_expression (produced) of GHS-Px associated with diabetes mellitus
4) Confidence 0.08 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1131912 Disease Relevance 0.58 Pain Relevance 0
Mekinova et al. demonstrated that supplementation of streptozotocin (STZ) diabetic rats with vitamins C, E, and beta-carotene for 8 weeks produced a significant reduction of TBARS levels, GHS, and GHS-Px, an increase in Cu-SOD, and no change in catalase activity in kidneys [42].
Positive_regulation (increase) of Neg (no) Gene_expression (produced) of GHS associated with diabetes mellitus
5) Confidence 0.08 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1131912 Disease Relevance 0.58 Pain Relevance 0
Mekinova et al. demonstrated that supplementation of streptozotocin (STZ) diabetic rats with vitamins C, E, and beta-carotene for 8 weeks produced a significant reduction of TBARS levels, GHS, and GHS-Px, an increase in Cu-SOD, and no change in catalase activity in kidneys [42].
Positive_regulation (increase) of Neg (no) Gene_expression (produced) of GHS-Px associated with diabetes mellitus
6) Confidence 0.08 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1131912 Disease Relevance 0.58 Pain Relevance 0
Mekinova et al. demonstrated that supplementation of streptozotocin (STZ) diabetic rats with vitamins C, E, and beta-carotene for 8 weeks produced a significant reduction of TBARS levels, GHS, and GHS-Px, an increase in Cu-SOD, and no change in catalase activity in kidneys [42].
Positive_regulation (increase) of Neg (no) Gene_expression (produced) of GHS associated with diabetes mellitus
7) Confidence 0.08 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1131912 Disease Relevance 0.58 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox