INT76608

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Context Info
Confidence 0.33
First Reported 1998
Last Reported 1998
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.53
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NFKB1) mitochondrion (NFKB1) cytoplasm (NFKB1)
cytosol (NFKB1) signal transduction (NFKB1) nucleolus (NFKB1)
NFKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 21 100.00 Very High Very High Very High
ketamine 33 99.54 Very High Very High Very High
withdrawal 3 88.48 High High
analgesia 3 88.32 High High
antagonist 3 82.84 Quite High
Disease Link Frequency Relevance Heat
Heart Rate Under Development 3 96.48 Very High Very High Very High
Hallucination 3 86.44 High High
Schizophrenia 3 80.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ketamine did not significantly alter PPI or the reduction of the P50 ERP.
Neg (not) Regulation (alter) of Negative_regulation (reduction) of P50 associated with ketamine
1) Confidence 0.33 Published 1998 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9683005 Disease Relevance 0.22 Pain Relevance 0.65
Although in humans NMDA receptors may not be involved in the regulation of PPI and P50 reduction, the most likely explanation for the lack of effect of ketamine on these sensory gating paradigms is the dose used in this experiment.
Regulation (regulation) of Negative_regulation (reduction) of P50 associated with ketamine and nmda receptor
2) Confidence 0.17 Published 1998 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9683005 Disease Relevance 0.24 Pain Relevance 0.75
Recently, much interest has been given to the role of glutamatergic N-methyl-D-aspartate receptors (NMDA) in sensory gating, such as prepulse inhibition (PPI) and reduction of the P50 evoked response potential (ERP).
Regulation (role) of Negative_regulation (reduction) of P50 associated with nmda receptor
3) Confidence 0.17 Published 1998 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9683005 Disease Relevance 0.08 Pain Relevance 0.35

General Comments

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