INT76611

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Context Info
Confidence 0.59
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 10
Disease Relevance 3.21
Pain Relevance 3.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Srms)
Anatomy Link Frequency
neck 1
Srms (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 12 99.84 Very High Very High Very High
tolerance 7 97.32 Very High Very High Very High
addiction 4 96.68 Very High Very High Very High
Pain 215 96.56 Very High Very High Very High
Antinociceptive 1 95.84 Very High Very High Very High
backache 97 92.44 High High
fortral 6 90.56 High High
Spinal cord 3 88.92 High High
Tendonitis 12 88.64 High High
Piles 16 87.68 High High
Disease Link Frequency Relevance Heat
Pain 210 96.56 Very High Very High Very High
Pathologic Constriction 152 95.36 Very High Very High Very High
Low Back Pain 99 92.44 High High
Tendinopathy 12 88.64 High High
Anorectal Disorders 16 87.68 High High
Sprains And Strains 18 84.80 Quite High
Stress 6 75.36 Quite High
Musculoskeletal Disease 6 51.36 Quite High
Fatigue 6 46.56 Quite Low
Shoulder Pain 48 38.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that one population of sigma sites, that has a high affinity for [3H]DTG, but is not equivalent with the [3H](+)-pentozocine labeled sigma1 subtype or the [3H]DTG labeled sigma2 subtype, is upregulated by morphine and, therefore, may play a role in the development of tolerance to or dependence on the effects of morphine.
Positive_regulation (upregulated) of sites associated with addiction, tolerance and morphine
1) Confidence 0.59 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9683013 Disease Relevance 0 Pain Relevance 1.60
Comparing the prevalence of SRMS between the computer and non-computer users over the past 7 days revealed a significantly higher prevalence of SRMS in the computer users than the non computer users (?
Positive_regulation (prevalence) of SRMS
2) Confidence 0.44 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2927507 Disease Relevance 0 Pain Relevance 0
Our male computer users had higher prevalence of SRMS than the females and the females were less likely to report musculoskeletal symptoms.
Positive_regulation (prevalence) of SRMS
3) Confidence 0.44 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2927507 Disease Relevance 0.09 Pain Relevance 0.09
This piece of information will help to further strengthen the fact that computer use actually contributes to the possibility of having higher prevalence of SRMS.
Positive_regulation (prevalence) of SRMS
4) Confidence 0.44 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2927507 Disease Relevance 0.27 Pain Relevance 0.19
However both the computer and non computer users had their highest prevalence of SRMS at the neck region during the past 12 month duration.
Positive_regulation (prevalence) of SRMS in neck
5) Confidence 0.44 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2927507 Disease Relevance 0.36 Pain Relevance 0.23
In conclusion, computer users had significantly higher prevalence of SRMS over the past 7 days and during the last 12 month assessment durations.
Positive_regulation (prevalence) of SRMS
6) Confidence 0.44 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2927507 Disease Relevance 0.11 Pain Relevance 0.08
However, the high prevalence of SRMS may point to the possibility of an underlying disorder.
Positive_regulation (prevalence) of SRMS
7) Confidence 0.44 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2927507 Disease Relevance 0.29 Pain Relevance 0.18
A retrospective analysis of 419 consecutive patients, which underwent SRM from December 1998 to August 2003 was performed.
Positive_regulation (underwent) of SRM
8) Confidence 0.40 Published 2004 Journal BMC Surg Section Abstract Doc Link PMC420246 Disease Relevance 0.82 Pain Relevance 0.08
All patients underwent SRM (Table 2).
Positive_regulation (underwent) of SRM
9) Confidence 0.40 Published 2004 Journal BMC Surg Section Body Doc Link PMC420246 Disease Relevance 0.70 Pain Relevance 0
This is because the SRM is dependent on both the effectiveness of the treatment and the patient population characteristics and therefore expected to vary in a study using two distinctly different patient populations [17,21,90].
Positive_regulation (dependent) of SRM
10) Confidence 0.02 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1635558 Disease Relevance 0.58 Pain Relevance 0.58

General Comments

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