INT76620

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Context Info
Confidence 0.78
First Reported 1998
Last Reported 2010
Negated 4
Speculated 6
Reported most in Abstract
Documents 93
Total Number 99
Disease Relevance 34.70
Pain Relevance 50.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cnr2) signal transducer activity (Cnr2)
Anatomy Link Frequency
bladder 8
paw 8
immune cells 6
thalamus 4
microglia 3
Cnr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cannabinoid 1114 100.00 Very High Very High Very High
Cannabinoid receptor 772 100.00 Very High Very High Very High
antagonist 641 100.00 Very High Very High Very High
Spinal cord 556 100.00 Very High Very High Very High
Central nervous system 92 100.00 Very High Very High Very High
agonist 1230 99.96 Very High Very High Very High
antinociception 33 99.96 Very High Very High Very High
Peripheral nervous system 2 99.92 Very High Very High Very High
Inflammation 343 99.82 Very High Very High Very High
Peripheral nerve injury 37 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Overactive Bladder 450 99.98 Very High Very High Very High
INFLAMMATION 363 99.82 Very High Very High Very High
Nervous System Injury 125 99.82 Very High Very High Very High
Low Back Pain 2 99.68 Very High Very High Very High
Pain 908 99.22 Very High Very High Very High
Neuropathic Pain 1210 98.92 Very High Very High Very High
Cirrhosis 62 98.66 Very High Very High Very High
Cv Unclassified Under Development 16 98.40 Very High Very High Very High
Cadaver 18 98.32 Very High Very High Very High
Interstitial Cystitis 144 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although much of the existing data suggest that the analgesic effects of cannabinoids are mediated via neuronal CB1 receptors, there is increasing evidence to support a role for peripheral CB2 receptors, which are expressed preferentially on immune cells.
Gene_expression (expressed) of CB2 in immune cells associated with cannabinoid and analgesic
1) Confidence 0.78 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12823482 Disease Relevance 0.75 Pain Relevance 0.95
Moreover, the appearance of CB2 expression coincides with the appearance of activated microglia.
Gene_expression (expression) of CB2 in microglia
2) Confidence 0.78 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12823482 Disease Relevance 0.74 Pain Relevance 0.88
We report here that chronic pain models associated with peripheral nerve injury, but not peripheral inflammation, induce CB2 receptor expression in a highly restricted and specific manner within the lumbar spinal cord.
Gene_expression (expression) of CB2 in peripheral nerve associated with nervous system injury, inflammation, lasting pain, spinal cord and peripheral nerve injury
3) Confidence 0.78 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12823482 Disease Relevance 0.77 Pain Relevance 0.92
Induction of CB2 receptor expression in the rat spinal cord of neuropathic but not inflammatory chronic pain models.
Gene_expression (expression) of CB2 in spinal cord associated with inflammation, lasting pain, neuropathic pain and spinal cord
4) Confidence 0.78 Published 2003 Journal Eur. J. Neurosci. Section Title Doc Link 12823482 Disease Relevance 0.75 Pain Relevance 1.37
To clarify the mechanisms underlying these effects we investigated CB2 gene expression and function in the nervous system.
Spec (investigated) Gene_expression (expression) of CB2 gene in nervous system
5) Confidence 0.77 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16553616 Disease Relevance 0.27 Pain Relevance 0.59
CB2 mRNA was expressed in spinal cord and dorsal root ganglia (DRG) of both sham and neuropathic rats and was up-regulated in the ipsilateral spinal cord of neuropathic rats.
Gene_expression (expressed) of CB2 mRNA in DRG associated with neuropathic pain and spinal cord
6) Confidence 0.77 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16553616 Disease Relevance 0.28 Pain Relevance 0.61
This dichotomy between CB2 and CB1 receptor expression in the CNS has, however, been dispelled by reports of CB2 receptor expression in the brainstem (Van Sickle et al., 2005) and higher brain centres, including the thalamus (Gong et al., 2006) and cerebellum (Ashton et al., 2006) in naïve rats, although their physiological roles are unclear.
Gene_expression (expression) of CB2 in thalamus associated with medulla, thalamus and central nervous system
7) Confidence 0.77 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2327204 Disease Relevance 0.42 Pain Relevance 0.88
CB2 receptor expression is also induced in the brains of rats subjected to hypoxia–ischemia, although in this situation the receptors appear to be located on non-neuronal cells including resident microglia or invading monocytes (Ashton et al., 2007).
Gene_expression (expression) of CB2 receptor in brains associated with hypoxia and ischemia
8) Confidence 0.77 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2327204 Disease Relevance 0.65 Pain Relevance 0.43
This dichotomy between CB2 and CB1 receptor expression in the CNS has, however, been dispelled by reports of CB2 receptor expression in the brainstem (Van Sickle et al., 2005) and higher brain centres, including the thalamus (Gong et al., 2006) and cerebellum (Ashton et al., 2006) in naïve rats, although their physiological roles are unclear.
Gene_expression (expression) of CB2 receptor in thalamus associated with medulla, thalamus and central nervous system
9) Confidence 0.77 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2327204 Disease Relevance 0.35 Pain Relevance 0.76
The expression of CB2 receptors at sites which modulate pain processing, such as the periaqueductal grey matter and thalamus (Gong et al., 2006), suggests that this receptor may modulate nociceptive neurotransmission, either directly or indirectly.
Gene_expression (expression) of CB2 in thalamus associated with nociception, pain, periaqueductal grey and thalamus
10) Confidence 0.77 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2327204 Disease Relevance 0.77 Pain Relevance 0.75
The cannabinoid receptor 2 protein in spinal cord appeared to be expressed on sensory neuron afferent terminals as it colocalized with two markers of damaged afferents, namely growth associated protein-43 and the neuropeptide galanin.
Gene_expression (expressed) of cannabinoid receptor 2 protein in spinal cord associated with cannabinoid receptor, neuropeptide and spinal cord
11) Confidence 0.76 Published 2005 Journal Neuroscience Section Abstract Doc Link 16084654 Disease Relevance 0.33 Pain Relevance 0.85
Olvanil was stable to enzymatic hydrolysis, and (i) displaced the binding of high affinity cannabinoid receptor ligands to membrane preparations from N18TG2 cells and guinea pig forebrain (Ki = 1.64-7.08 microM), but not from cells expressing the CB2 cannabinoid receptor subtype; (ii) inhibited forskolin-induced cAMP formation in intact N18TG2 cells (IC50 = 1.60 microM), this effect being reversed by the selective CB1 antagonist SR141716A.
Gene_expression (expressing) of CB2 in N18TG2 associated with cannabinoid receptor and antagonist
12) Confidence 0.75 Published 1998 Journal FEBS Lett. Section Abstract Doc Link 9801167 Disease Relevance 0.07 Pain Relevance 0.58
As there is no evidence for an increased population of neuroimmune cells in the thalamus of neuropathic rats, the most parsimonious explanation of the present data is an increased expression of CB2 receptors on thalamic neurons, although this requires verification by immunohistochemical approaches.
Gene_expression (expression) of CB2 in neurons associated with neuropathic pain and thalamus
13) Confidence 0.67 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2327204 Disease Relevance 0.69 Pain Relevance 0.46
In other brain regions, such as the amygdala, the antinociceptive effects of intrabasolateral amygdala injection of WIN55212 in formalin and tail-flick tests were abolished by CB1 receptor antagonism but not CB2 receptor antagonism in naïve rats (Hasanein et al., 2007).
Neg (not) Gene_expression (antagonism) of CB2 receptor in amygdala associated with tail-flick, antinociceptive and amygdala
14) Confidence 0.67 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2327204 Disease Relevance 0.42 Pain Relevance 0.72
Peripheral nerve injury induces cannabinoid receptor 2 protein expression in rat sensory neurons.
Gene_expression (expression) of cannabinoid receptor 2 protein in sensory neurons associated with nervous system injury, cannabinoid receptor and peripheral nerve injury
15) Confidence 0.67 Published 2005 Journal Neuroscience Section Title Doc Link 16084654 Disease Relevance 0.33 Pain Relevance 0.91
CB2 receptors in the spinal cord were co-localised with activated microglia in neuropathic rats [9], which is in keeping with earlier reports of CB2 receptor expression in microglia [11,12].
Gene_expression (expression) of CB2 receptor in microglia associated with neuropathic pain and spinal cord
16) Confidence 0.66 Published 2009 Journal Mol Pain Section Body Doc Link PMC2719614 Disease Relevance 1.13 Pain Relevance 1.04
The Ki value of AM4113 (0.80 +/- 0.44 nM) in competitive binding assays with the CB1/2 agonist [3H]CP55,940 was 100-fold more selective for CB1 over CB2 receptors.
Gene_expression (selective) of CB2 associated with agonist
17) Confidence 0.65 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17959701 Disease Relevance 0.84 Pain Relevance 0.45
Pretreatment with the CB1 and CB2 cannabinoid receptor antagonists N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-3-pyrazole-carboxamide (SR141716) and N-[1S)-endo-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-pyrazole-3-carboxamide (SR144528) did not affect the responses to anandamide.
Gene_expression (Pretreatment) of CB2 associated with cannabinoid receptor and antagonist
18) Confidence 0.65 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12538826 Disease Relevance 0.31 Pain Relevance 0.73
Agonists selective for CB2 cannabinoid receptors, which are not found in the CNS, do not produce the CNS effects typical of nonselective cannabinoid receptor agonists but do inhibit acute nociception.
Gene_expression (selective) of CB2 in CNS associated with nociception, cannabinoid receptor, agonist and central nervous system
19) Confidence 0.65 Published 2003 Journal Anesthesiology Section Abstract Doc Link 14508331 Disease Relevance 0.43 Pain Relevance 1.03
Neutral antagonist and binding properties were confirmed in HEK-293 cells transfected with human CB1 or CB2 receptors.
Gene_expression (transfected) of CB2 associated with antagonist
20) Confidence 0.65 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17959701 Disease Relevance 0.60 Pain Relevance 0.35

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