INT76621

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Context Info
Confidence 0.69
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 32
Total Number 36
Disease Relevance 17.77
Pain Relevance 26.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cnr2) signal transducer activity (Cnr2)
Anatomy Link Frequency
spinal 6
nerve 1
neurons 1
bladder 1
DRG 1
Cnr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cannabinoid 331 100.00 Very High Very High Very High
Cannabinoid receptor 217 100.00 Very High Very High Very High
Inflammation 164 100.00 Very High Very High Very High
Spinal cord 132 100.00 Very High Very High Very High
Analgesic 94 100.00 Very High Very High Very High
Antinociceptive 27 100.00 Very High Very High Very High
nociceptor 22 100.00 Very High Very High Very High
antagonist 176 99.96 Very High Very High Very High
Hyperalgesia 35 99.92 Very High Very High Very High
antinociception 10 99.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 238 100.00 Very High Very High Very High
INFLAMMATION 145 99.98 Very High Very High Very High
Hyperalgesia 37 99.92 Very High Very High Very High
Inflammatory Pain 18 99.90 Very High Very High Very High
Nociception 113 99.70 Very High Very High Very High
Pain 262 99.44 Very High Very High Very High
Apoptosis 10 99.28 Very High Very High Very High
Anxiety Disorder 16 99.16 Very High Very High Very High
Vomiting 25 98.24 Very High Very High Very High
Overactive Bladder 125 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cannabinoid 2 (CB2) receptor mediated antinociception and increased levels of spinal CB2 receptor mRNA are reported in neuropathic Sprague-Dawley rats.
Positive_regulation (increased) of CB2 in spinal associated with antinociception, cannabinoid and neuropathic pain
1) Confidence 0.69 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16045490 Disease Relevance 0.56 Pain Relevance 0.57
CB2 mRNA was expressed in spinal cord and dorsal root ganglia (DRG) of both sham and neuropathic rats and was up-regulated in the ipsilateral spinal cord of neuropathic rats.
Positive_regulation (up-regulated) of CB2 mRNA in DRG associated with neuropathic pain and spinal cord
2) Confidence 0.69 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16553616 Disease Relevance 0.29 Pain Relevance 0.71
Indeed, CB2 receptor protein was shown to be increased in the afferent terminals of sensory nerves in the superficial laminae of the dorsal horn of the spinal cord after peripheral nerve damage Wotherspoon et al. (2005).
Positive_regulation (increased) of CB2 receptor in dorsal horn associated with nervous system injury, dorsal horn and spinal cord
3) Confidence 0.69 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2327204 Disease Relevance 0.74 Pain Relevance 0.49
Activation of cannabinoid CB1 and CB2 receptors is known to attenuate nociception and hyperalgesia in somatic inflammatory conditions.
Positive_regulation (Activation) of CB2 associated with nociception, hyperalgesia, inflammation and cannabinoid
4) Confidence 0.68 Published 2006 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 16961698 Disease Relevance 0.71 Pain Relevance 0.46
In the peripheral nerve, accumulation of cannabinoid receptor 2 immunoreactivity was seen in nerve sections proximal, but not distal, to the ligation site, suggesting transport down the nerve from the cell bodies.
Positive_regulation (accumulation) of cannabinoid receptor 2 in nerve associated with cannabinoid receptor
5) Confidence 0.68 Published 2005 Journal Neuroscience Section Abstract Doc Link 16084654 Disease Relevance 0.36 Pain Relevance 0.87
These data demonstrate that activation of cannabinoid CB2 receptors is sufficient to suppress neuronal activity at central levels of processing in the spinal dorsal horn.
Positive_regulation (activation) of CB2 in spinal associated with spinal dorsal horn and cannabinoid
6) Confidence 0.68 Published 2004 Journal J. Neurophysiol. Section Abstract Doc Link 15317842 Disease Relevance 0.23 Pain Relevance 0.82
Activation of CB1 and CB2 receptors attenuates the induction and maintenance of inflammatory pain in the rat.
Positive_regulation (Activation) of CB2 associated with analgesic and ipn
7) Confidence 0.67 Published 2005 Journal Pain Section Title Doc Link 16289798 Disease Relevance 0.53 Pain Relevance 1.13
Intraplantar injection of anandamide inhibits mechanically-evoked responses of spinal neurones via activation of CB2 receptors in anaesthetised rats.
Positive_regulation (activation) of CB2 in spinal associated with cannabinoid
8) Confidence 0.67 Published 2003 Journal Neuropharmacology Section Title Doc Link 12871657 Disease Relevance 0.40 Pain Relevance 0.63
In conclusion, in enteric nerves anandamide stimulates VIP release by activation of a CB2 receptor specific pathway, while the stimulation of NO production suggests the existence of an additional type of cannabinoid receptor in the enteric nervous system.
Positive_regulation (activation) of CB2 in enteric nervous system associated with cannabinoid receptor
9) Confidence 0.64 Published 2008 Journal Neuropeptides Section Abstract Doc Link 18829105 Disease Relevance 0 Pain Relevance 0.27
CB1 receptor staining in the L5 dorsal horn was significantly reduced on postoperative days 1 and 9 and spinal CB2 receptor staining was significantly increased on day 1 compared to staining in naïve animals (Figures S3 and S4).
Positive_regulation (increased) of CB2 receptor in spinal associated with dorsal horn
10) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 0.22 Pain Relevance 0.26
The identification of peripherally expressed CB2 receptors and reports that the selective activation of cannabinoid CB2 receptors produces antinociception without traditional cannabinergic side effects suggests that selective cannabinoid CB2 receptor agonists might be useful in the management of pain.
Positive_regulation (activation) of CB2 associated with pain, antinociception, cannabinoid and agonist
11) Confidence 0.49 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16316653 Disease Relevance 0.17 Pain Relevance 0.69
Inhibition of inflammatory hyperalgesia by activation of peripheral CB2 cannabinoid receptors.
Positive_regulation (activation) of CB2 associated with hyperalgesia, cannabinoid receptor, inflammation and analgesic
12) Confidence 0.49 Published 2003 Journal Anesthesiology Section Title Doc Link 14508331 Disease Relevance 0.48 Pain Relevance 1.45
In conclusion, likely by activating CB1 and CB2 receptors, WIN afforded robust neuroprotection in newborn rats after HI.
Positive_regulation (activating) of CB2
13) Confidence 0.49 Published 2007 Journal Pediatr. Res. Section Abstract Doc Link 17622949 Disease Relevance 0.44 Pain Relevance 0.38
The authors used the CB2 receptor-selective agonist AM1241 to test the hypothesis that selective activation of peripheral CB2 receptors inhibits inflammatory hyperalgesia.
Positive_regulation (activation) of CB2 associated with hyperalgesia, inflammation and agonist
14) Confidence 0.49 Published 2003 Journal Anesthesiology Section Abstract Doc Link 14508331 Disease Relevance 0.61 Pain Relevance 1.00
This study demonstrates that activation of peripheral CB2 receptors attenuates both innocuous- and noxious-evoked responses of WDR neurons in models of acute, inflammatory and neuropathic pain.
Positive_regulation (activation) of CB2 in neurons associated with inflammation, neuropathic pain and wide dynamic range
15) Confidence 0.49 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15525273 Disease Relevance 0.40 Pain Relevance 0.86
Activation of cannabinoid CB2 receptors suppresses C-fiber responses and windup in spinal wide dynamic range neurons in the absence and presence of inflammation.
Positive_regulation (Activation) of CB2 in spinal associated with c fibre, inflammation, analgesic, cannabinoid and wide dynamic range
16) Confidence 0.46 Published 2004 Journal J. Neurophysiol. Section Title Doc Link 15317842 Disease Relevance 0.26 Pain Relevance 1.24
Direct agonists selectively activate either CB1 or CB2 receptor.
Positive_regulation (activate) of CB2 associated with agonist
17) Confidence 0.45 Published 2010 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2878434 Disease Relevance 0.65 Pain Relevance 1.22
Activation of CB1 and CB2 receptors attenuated the electrically evoked contraction of detrusor strips.
Positive_regulation (Activation) of CB2 associated with overactive bladder
18) Confidence 0.45 Published 2010 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2878434 Disease Relevance 0.38 Pain Relevance 0.21
In general, stimulation of the G protein-coupled cannabinoid receptors types 1 and 2 (CB1 and CB2) results in inhibition of nociceptive signaling pathways (reviewed in [2]).
Positive_regulation (stimulation) of CB2 associated with nociception and cannabinoid receptor
19) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 1.48 Pain Relevance 1.59
Recently the possibility to target CB2 has emerged as an alternative for the treatment of pain.
Positive_regulation (target) of CB2 associated with pain
20) Confidence 0.36 Published 2009 Journal J. Soc. Biol. Section Abstract Doc Link 19358815 Disease Relevance 0.91 Pain Relevance 1.00

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