INT7663

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Context Info
Confidence 0.67
First Reported 1981
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 17
Disease Relevance 3.05
Pain Relevance 8.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Pck1) nucleolus (Pck1) nucleus (Pck1)
lipid metabolic process (Pck1) cytoplasm (Pck1)
Anatomy Link Frequency
caudate nucleus 1
liver 1
telencephalon 1
brain 1
external 1
Pck1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 43 100.00 Very High Very High Very High
Morphine 14 99.98 Very High Very High Very High
addiction 2 99.96 Very High Very High Very High
tolerance 7 99.66 Very High Very High Very High
MU agonist 3 99.58 Very High Very High Very High
Opioid 74 99.50 Very High Very High Very High
opiate 15 99.46 Very High Very High Very High
Antinociceptive 4 99.16 Very High Very High Very High
Hippocampus 2 98.88 Very High Very High Very High
Enkephalin 11 98.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bordatella Infection 20 100.00 Very High Very High Very High
Diabetes Mellitus 212 99.64 Very High Very High Very High
Apoptosis 9 98.40 Very High Very High Very High
Targeted Disruption 25 87.76 High High
Urological Neuroanatomy 1 73.36 Quite High
Cardiovascular Disease 1 65.24 Quite High
Vibrio Infection 1 63.16 Quite High
INFLAMMATION 3 63.00 Quite High
Myocardial Infarction 1 54.76 Quite High
Nociception 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
From these results, it is suggested that the coupling activity of alpha 2-adrenoceptor with GTP-binding protein gradually develops in a manner parallel with the increase of alpha 2-adrenoceptor and pertussis toxin sensitive GTP-binding proteins, Gi, and that alpha 39 beta 36 gamma may be related to the differentiation and/or growth of nerve cells in rat telencephalon.
Positive_regulation (increase) of GTP in telencephalon associated with bordatella infection
1) Confidence 0.67 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2542460 Disease Relevance 0.30 Pain Relevance 0.11
Recently, an additional subtype that is coupled to GTP binding proteins and stimulates (or inhibits) metabolism of phosphoinositides has been proposed as a metabotropic receptor.
Positive_regulation (coupled) of GTP
2) Confidence 0.49 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1353790 Disease Relevance 0 Pain Relevance 0.22
Seven days of chronic sufentanil treatment developed antinociceptive tolerance associated with a reduction in mu-agonist-induced [35S]GTP gamma S binding, mu-agonist-induced adenylyl cyclase inhibition, and co-precipitation of G alpha o, G alpha i2 G alpha z and G alpha q11 subunits with mu-opioid receptors.
Positive_regulation (mu-agonist-induced) of GTP associated with mu opioid receptor, agonist, tolerance and antinociceptive
3) Confidence 0.49 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18384820 Disease Relevance 0.17 Pain Relevance 1.06
Signal transduction correlates of mu opioid agonist intrinsic efficacy: receptor-stimulated [35S]GTP gamma S binding in mMOR-CHO cells and rat thalamus.
Positive_regulation (receptor-stimulated) of GTP in thalamus associated with mu agonist, enkephalin and thalamus
4) Confidence 0.49 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 9580589 Disease Relevance 0 Pain Relevance 0.87
In membrane assays, with 20 microM GDP, ORL1 peptide stimulated [35S]GTP gamma S binding by approximately two-fold with an ED50 value of 20 nM.
Positive_regulation (stimulated) of GTP
5) Confidence 0.49 Published 1996 Journal Neuroreport Section Abstract Doc Link 8733732 Disease Relevance 0 Pain Relevance 0.29
As N-ethylmaleimide has been reported to inactivate Gi protein and to block the regulation of noradrenaline release by alpha 2-adrenoceptors, the present results suggest that N-ethylmaleimide inactivates inhibitory GTP binding proteins to block the regulation by dopamine autoreceptors of evoked dopamine release.
Positive_regulation (inactivates) of GTP associated with dopamine and noradrenaline
6) Confidence 0.49 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7916300 Disease Relevance 0 Pain Relevance 0.66
These findings suggest that the excitatory responses to opioid agonists in hippocampus are the result of interactions with receptors that are coupled via pertussis toxin sensitive GTP-binding proteins to their respective effector mechanisms.
Positive_regulation (coupled) of GTP in hippocampus associated with mu agonist, bordatella infection and hippocampus
7) Confidence 0.49 Published 1988 Journal Neurosci. Lett. Section Abstract Doc Link 2852323 Disease Relevance 0.34 Pain Relevance 0.59
Chronic (in vivo) administration of morphine pellets for 5 days, treatment known to induce opiate tolerance and dependence, increased basal, GTP- and forskolin-stimulated adenylate cyclase in the LC, but not in the other three brain regions studied.
Positive_regulation (increased) of GTP in brain associated with addiction, locus ceruleus, tolerance, opiate and morphine
8) Confidence 0.45 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2843624 Disease Relevance 0.25 Pain Relevance 1.55
Roflumilast increased Epac1/GTP-Rap1 and the protective effect was abolished by Epac1 siRNA transfection, demonstrating that Epac signaling was also involved in this protective response.
Positive_regulation (increased) of GTP
9) Confidence 0.45 Published 2008 Journal Cell. Signal. Section Abstract Doc Link 18276108 Disease Relevance 0.77 Pain Relevance 0.06
Similar treatment with tetrandrine reversed the elevated mRNA and protein levels of PEPCK in the liver of STZ-diabetic rats.
Positive_regulation (elevated) of PEPCK in liver associated with diabetes mellitus
10) Confidence 0.40 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Abstract Doc Link PMC516459 Disease Relevance 0.68 Pain Relevance 0.34
In the preliminary experiments, tetrandrine was found to significantly modify mRNA and protein levels of glucose transporters subtype 4 (GLUT4) and hepatic phosphoenolpyruvate carboxykinase (PEPCK) in STZ-diabetic rats after a 3-day treatment.
Positive_regulation (modify) of PEPCK associated with diabetes mellitus
11) Confidence 0.37 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC516459 Disease Relevance 0.26 Pain Relevance 0.09
Morphine enhanced the inhibitory actions of GTP and GTPase-resistant Gpp(NH)p on the adenylate cyclase activity.
Positive_regulation (enhanced) of GTP associated with morphine
12) Confidence 0.16 Published 1981 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 6273623 Disease Relevance 0 Pain Relevance 1.07
We propose that activation of either the external ATP or GTP receptors causes a change in somatic membrane ion conductance to depolarize the cell to a threshold level, generate action potentials and AR and result in chemorepulsion.
Positive_regulation (activation) of GTP in external associated with action potential
13) Confidence 0.14 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096533 Disease Relevance 0 Pain Relevance 0.15
These results suggest that GTP plays an important role in the regulation of adenylate cyclase activity in the rat caudate nucleus and that the occupation of opiate receptor by agonists inhibits the enzyme through an actual increase in the inhibitory action of GTP, rather than a suppression of the enzymatic degradation of GTP.
Positive_regulation (increase) of GTP in caudate nucleus associated with agonist and opiate
14) Confidence 0.13 Published 1981 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 6273623 Disease Relevance 0 Pain Relevance 0.97
Responses to ATP and GTP in other ciliates
Positive_regulation (Responses) of GTP
15) Confidence 0.12 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096533 Disease Relevance 0 Pain Relevance 0.08
A Paramecium mutant (ginA) lacks the GTP-induced oscillating depolarizations but does show AR in GTP, unveiling isolated GTP-receptor potentials for study.
Positive_regulation (show) of GTP
16) Confidence 0.12 Published 2005 Journal Purinergic Signal Section Abstract Doc Link PMC2096533 Disease Relevance 0.09 Pain Relevance 0.03
Thus, the synergistic interaction appears to result from opioid- and muscarinic-induced activation of a pertussis toxin-sensitive GTP-binding protein which may potentiate the adenylyl cyclase stimulation by the stimulatory GTP-binding protein activated by either VIP or CRH receptors.
Positive_regulation (activation) of GTP associated with bordatella infection and opioid
17) Confidence 0.11 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8245971 Disease Relevance 0.19 Pain Relevance 0.48

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