INT7664

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Context Info
Confidence 0.49
First Reported 1992
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 68
Total Number 71
Disease Relevance 10.11
Pain Relevance 29.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Grip2) plasma membrane (Grip2) cytoskeleton (Grip2)
cytoplasm (Grip2)
Anatomy Link Frequency
neurons 4
synapses 2
soma 2
dorsal horn 2
proximal 2
Grip2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 560 100.00 Very High Very High Very High
depression 502 100.00 Very High Very High Very High
Glutamate 496 100.00 Very High Very High Very High
antagonist 473 100.00 Very High Very High Very High
Glutamate receptor 185 99.96 Very High Very High Very High
neuralgia 3 99.86 Very High Very High Very High
Nucleus accumbens 130 99.84 Very High Very High Very High
Hippocampus 93 99.82 Very High Very High Very High
orphanin 11 99.82 Very High Very High Very High
nMDA receptor antagonist 82 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 499 100.00 Very High Very High Very High
INFLAMMATION 43 99.22 Very High Very High Very High
Neuropathic Pain 4 99.08 Very High Very High Very High
Alzheimer's Dementia 5 98.32 Very High Very High Very High
Pain 51 98.24 Very High Very High Very High
Heart Rate Under Development 420 97.80 Very High Very High Very High
Frailty 4 97.04 Very High Very High Very High
Amnesia 7 96.88 Very High Very High Very High
Disease 71 96.56 Very High Very High Very High
Neurodegenerative Disease 3 95.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present findings point out a selective down-regulation of AMPA receptor subunits in the transduction of trigeminal pain.
Negative_regulation (regulation) of AMPA receptor associated with pain
1) Confidence 0.49 Published 1999 Journal Neuroscience Section Abstract Doc Link 10188946 Disease Relevance 0.48 Pain Relevance 0.52
These results demonstrate that the AMPA-receptor blockade within the RVLM that attenuates cardiovascular responses during mechanical stimulation is associated with a reduction in extracellular levels of glutamate.
Negative_regulation (blockade) of AMPA-receptor in RVLM associated with glutamate and rostral ventrolateral medulla
2) Confidence 0.43 Published 2001 Journal Pharmacol. Res. Section Abstract Doc Link 11207065 Disease Relevance 0 Pain Relevance 0.60
We investigated the effects of AMPA-receptor blockade in the rostral ventrolateral medulla (RVLM) on cardiovascular responses and extracellular concentrations of glutamate during two different types of stimuli that activate peripheral Adelta - and C-fiber polymodal nociceptors using anesthetized rats.
Spec (investigated) Negative_regulation (blockade) of AMPA-receptor in nociceptors associated with c fibre, glutamate, rostral ventrolateral medulla, nociceptor and adelta
3) Confidence 0.43 Published 2001 Journal Pharmacol. Res. Section Abstract Doc Link 11207065 Disease Relevance 0 Pain Relevance 0.41
AMPA-receptor blockade within the RVLM modulates cardiovascular responses via glutamate during peripheral stimuli.
Negative_regulation (blockade) of AMPA-receptor associated with glutamate
4) Confidence 0.43 Published 2001 Journal Pharmacol. Res. Section Title Doc Link 11207065 Disease Relevance 0 Pain Relevance 0.51
The novel finding of this study is that carrageenan-induced inflammation, in the presence of cyclothiazide, an inhibitor of AMPA receptor desensitization, produces a sustained facilitation of the AMPA-mediated membrane current and rises in [Ca2+]i in both the soma and proximal dendrites of SG neurons recorded on the injected side 3 h after the induction of inflammation.
Negative_regulation (inhibitor) of AMPA in soma associated with substantia gelatinosa and inflammation
5) Confidence 0.43 Published 2004 Journal Cell Calcium Section Abstract Doc Link 15003855 Disease Relevance 0.35 Pain Relevance 0.48
The novel finding of this study is that carrageenan-induced inflammation, in the presence of cyclothiazide, an inhibitor of AMPA receptor desensitization, produces a sustained facilitation of the AMPA-mediated membrane current and rises in [Ca2+]i in both the soma and proximal dendrites of SG neurons recorded on the injected side 3 h after the induction of inflammation.
Negative_regulation (desensitization) of AMPA in soma associated with substantia gelatinosa and inflammation
6) Confidence 0.43 Published 2004 Journal Cell Calcium Section Abstract Doc Link 15003855 Disease Relevance 0.35 Pain Relevance 0.48
However, AMPA receptor desensitization does not appear to play a role in this process in this structure.
Negative_regulation (desensitization) of AMPA receptor
7) Confidence 0.42 Published 1997 Journal Neurochem. Int. Section Abstract Doc Link 9041561 Disease Relevance 0 Pain Relevance 0.17
The present results suggest that pharmacological block of AMPA receptor desensitization led to strong excitation of motoneurons and indicate a physiological role of desensitization in protecting these nerve cells from overactivity.
Negative_regulation (desensitization) of AMPA receptor in nerve cells
8) Confidence 0.42 Published 1995 Journal Eur. J. Neurosci. Section Abstract Doc Link 7582096 Disease Relevance 0.09 Pain Relevance 0.19
We have also investigated whether AMPA receptor desensitization, a well documented event, plays a role in AMPA receptor modulation of striatal 5-HT release.
Spec (whether) Negative_regulation (desensitization) of AMPA receptor
9) Confidence 0.37 Published 1997 Journal Neurochem. Int. Section Abstract Doc Link 9041561 Disease Relevance 0 Pain Relevance 0.29
Spinal AMPA receptor inhibition attenuates mechanical allodynia and neuronal hyperexcitability following spinal cord injury in rats.
Negative_regulation (inhibition) of AMPA receptor in Spinal associated with neuralgia, allodynia, hyperexcitability and spinal cord
10) Confidence 0.37 Published 2007 Journal J. Neurosci. Res. Section Title Doc Link 17549753 Disease Relevance 0.55 Pain Relevance 0.95
Diazoxide (500 microM), a drug which prevents AMPA receptor desensitization, failed to augment the effect of 100 microM AMPA on 5-HT release.
Negative_regulation (prevents) of AMPA receptor
11) Confidence 0.36 Published 1997 Journal Neurochem. Int. Section Abstract Doc Link 9041561 Disease Relevance 0 Pain Relevance 0.27
Desensitization of AMPA receptors limits the amplitude of EPSPs and the excitability of motoneurons of the rat isolated spinal cord.
Negative_regulation (Desensitization) of AMPA in motoneurons associated with spinal cord
12) Confidence 0.36 Published 1995 Journal Eur. J. Neurosci. Section Title Doc Link 7582096 Disease Relevance 0.07 Pain Relevance 0.21
Down-regulation of AMPA receptors did not alter basal O2 consumption.
Negative_regulation (Down-regulation) of AMPA
13) Confidence 0.36 Published 2004 Journal Neurochem. Res. Section Abstract Doc Link 15202775 Disease Relevance 0 Pain Relevance 0.38
Specifically, AMPA receptor seems to be predominant in the glutamate-induced malondialdehdye production in anesthetized rat brain cortex.
Negative_regulation (predominant) of AMPA receptor in cortex associated with glutamate
14) Confidence 0.35 Published 2003 Journal Redox Rep. Section Abstract Doc Link 12631442 Disease Relevance 0 Pain Relevance 0.49
Down-regulation of AMPA glutamate receptors reduces cerebrocortical metabolic response to stimulation.
Negative_regulation (Down-regulation) of AMPA associated with glutamate receptor
15) Confidence 0.31 Published 2004 Journal Neurochem. Res. Section Title Doc Link 15202775 Disease Relevance 0 Pain Relevance 0.36
AMPA down-regulation reduced the agonist stimulated increase in cortical O2 consumption.
Negative_regulation (down-regulation) of AMPA associated with agonist
16) Confidence 0.23 Published 2004 Journal Neurochem. Res. Section Abstract Doc Link 15202775 Disease Relevance 0 Pain Relevance 0.29
Glycine, acting at strychnine-sensitive receptors, also inhibited the effect of AMPA, but only in part.
Negative_regulation (inhibited) of AMPA
17) Confidence 0.17 Published 2001 Journal Neuroscience Section Abstract Doc Link 11564428 Disease Relevance 0 Pain Relevance 0.55
Muscimol inhibited completely the AMPA effect on [(3)H]acetylcholine release; muscimol was potentiated by diazepam and antagonized by SR95531, indicating the involvement of benzodiazepine-sensitive GABA(A) receptors.
Negative_regulation (inhibited) of AMPA associated with gaba
18) Confidence 0.17 Published 2001 Journal Neuroscience Section Abstract Doc Link 11564428 Disease Relevance 0 Pain Relevance 0.54
Blockade of AMPA receptors with CNQX on the test day did not alter these behavioural responses.
Negative_regulation (Blockade) of AMPA
19) Confidence 0.16 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 18671727 Disease Relevance 0 Pain Relevance 0.89
The novel finding of this study is that carrageenan-induced inflammation, in the presence of cyclothiazide, an inhibitor of AMPA receptor desensitization, produces a sustained facilitation of the AMPA-mediated membrane current and rises in [Ca2+]i in both the soma and proximal dendrites of SG neurons recorded on the injected side 3 h after the induction of inflammation.
Negative_regulation (inhibitor) of AMPA in proximal associated with substantia gelatinosa and inflammation
20) Confidence 0.15 Published 2004 Journal Cell Calcium Section Abstract Doc Link 15003855 Disease Relevance 0.35 Pain Relevance 0.48

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