INT76649

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Context Info
Confidence 0.22
First Reported 1998
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 12
Total Number 13
Disease Relevance 1.91
Pain Relevance 5.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TRIM54) signal transduction (TRIM54) cytoskeleton (TRIM54)
intracellular (TRIM54) cytoplasm (TRIM54) signal transducer activity (TRIM54)
Anatomy Link Frequency
lung 3
leukocytes 1
muscle 1
neural 1
blood cells 1
TRIM54 (Homo sapiens)
Pain Link Frequency Relevance Heat
opiate 38 100.00 Very High Very High Very High
Morphine 15 100.00 Very High Very High Very High
Opioid receptor 1 13 99.96 Very High Very High Very High
opioid receptor 2 99.52 Very High Very High Very High
Opioid 19 96.10 Very High Very High Very High
mu opioid receptor 4 87.04 High High
Neuropeptide 1 66.24 Quite High
Catecholamine 1 64.88 Quite High
Enkephalin 2 63.48 Quite High
narcan 2 62.96 Quite High
Disease Link Frequency Relevance Heat
Muscular Atrophy 100 99.60 Very High Very High Very High
Lung Cancer 12 99.48 Very High Very High Very High
Frailty 28 88.72 High High
Stress 8 32.96 Quite Low
Nociception 1 25.00 Low Low
Hypokinesia 2 15.56 Low Low
Arthritis 2 10.84 Low Low
Aging 2 10.24 Low Low
Neuromuscular Disease 2 9.40 Low Low
Chronic Renal Failure 2 7.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Displacement analysis revealed that a variety of opioid peptides were found to be ineffective in displacing specifically bound 3H dihydromorphine and only delta2 ligands were effective in regard to 3H Ala2-met5 enkephalinamide (DAMA), indicating the presence of mu3 and delta2 opioid receptor sites, respectively.
Gene_expression (presence) of mu3 associated with opioid receptor and opioid
1) Confidence 0.22 Published 1998 Journal Int. J. Cardiol. Section Abstract Doc Link 9687092 Disease Relevance 0 Pain Relevance 0.57
In addition, the expression of atrogin-1 and MuRF-1 during muscle atrophy in humans is contentious, with some studies showing increased atrogin-1 and MuRF-1 mRNA, but not others [26], [28]–[31].
Gene_expression (expression) of MuRF in muscle associated with muscular atrophy
2) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0.64 Pain Relevance 0
However, we were unable to detect atrogin-1 and MuRF protein using commercial antibodies (Abcam) and limited quantities of sample precluded direct measurements of Ub-proteasome activity.
Neg (unable) Gene_expression (detect) of MuRF
3) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0.23 Pain Relevance 0
Recent empirical data have elucidated a compelling physiological basis for endogenously expressed, chemically authentic, morphine and its cognate mu3 and mu4 opiate receptors.
Gene_expression (expressed) of mu3 associated with opiate and morphine
4) Confidence 0.09 Published 2008 Journal Semin. Cancer Biol. Section Abstract Doc Link 18191410 Disease Relevance 0 Pain Relevance 0.56
Studies from our laboratory have revealed a novel mu opiate receptor, mu 3, which is expressed in both vascular tissues and leukocytes.
Gene_expression (expressed) of mu 3 in leukocytes associated with opioid receptor 1
5) Confidence 0.09 Published 2003 Journal J. Immunol. Section Abstract Doc Link 12734358 Disease Relevance 0 Pain Relevance 0.43
Molecular identification and functional expression of mu 3, a novel alternatively spliced variant of the human mu opiate receptor gene.
Gene_expression (expression) of mu 3 associated with opioid receptor 1
6) Confidence 0.07 Published 2003 Journal J. Immunol. Section Title Doc Link 12734358 Disease Relevance 0 Pain Relevance 0.95
When mu3 is expressed in a heterologous system, the protein produced from this cDNA exhibits all of the expected biochemical characteristics of the mu3 receptor.
Gene_expression (expressed) of mu3
7) Confidence 0.05 Published 2004 Journal Med. Sci. Monit. Section Abstract Doc Link 15173681 Disease Relevance 0 Pain Relevance 0.44
When mu3 is expressed in a heterologous system, the protein produced from this cDNA exhibits all of the expected biochemical characteristics of the mu3 receptor.
Gene_expression (expressed) of mu3
8) Confidence 0.04 Published 2004 Journal Med. Sci. Monit. Section Abstract Doc Link 15173681 Disease Relevance 0 Pain Relevance 0.44
The mu3 opiate receptor subtype is expressed in human surgical specimens of both normal lung and non-small-cell lung carcinoma.
Gene_expression (expressed) of mu3 in lung associated with lung cancer and opiate
9) Confidence 0.03 Published 1999 Journal Cancer Lett. Section Abstract Doc Link 10656608 Disease Relevance 0.33 Pain Relevance 0.46
Mu3 opiate receptor expression in lung and lung carcinoma: ligand binding and coupling to nitric oxide release.
Gene_expression (expression) of Mu3 in lung associated with lung cancer and opiate
10) Confidence 0.03 Published 1999 Journal Cancer Lett. Section Title Doc Link 10656608 Disease Relevance 0.36 Pain Relevance 0.54
BACKGROUND: Studies from our laboratory have identified a novel mu opiate receptor, mu3, which is expressed in several tissues, such as human vascular endothelial cells, leukocytes and invertebrate neural tissues.
Gene_expression (expressed) of mu3 in neural associated with opioid receptor 1
11) Confidence 0.02 Published 2004 Journal Med. Sci. Monit. Section Abstract Doc Link 15448587 Disease Relevance 0 Pain Relevance 0.35
BACKGROUND: In previous studies, we have attributed opiate alkaloid selectivity to a subtype of the neuronal mu receptor known as mu3, expressed on human blood cells.
Gene_expression (expressed) of mu3 in blood cells associated with opiate
12) Confidence 0.01 Published 2001 Journal Med. Sci. Monit. Section Abstract Doc Link 11687719 Disease Relevance 0 Pain Relevance 0.27
Mu3 opiate receptor expression in lung and lung carcinoma: ligand binding and coupling to nitric oxide release.
Gene_expression (expression) of Mu3 in lung associated with lung cancer and opiate
13) Confidence 0.01 Published 1999 Journal Cancer Lett. Section Title Doc Link 10656608 Disease Relevance 0.36 Pain Relevance 0.54

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