INT7665

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Context Info
Confidence 0.45
First Reported 1992
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 2.87
Pain Relevance 6.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Npy1r) plasma membrane (Npy1r) molecular_function (Npy1r)
signal transducer activity (Npy1r)
Anatomy Link Frequency
substantia gelatinosa 2
nucleus accumbens 1
DRG 1
nociceptors 1
DGCs 1
Npy1r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 22 100.00 Very High Very High Very High
antagonist 4 100.00 Very High Very High Very High
substantia gelatinosa 2 99.96 Very High Very High Very High
fluoxetine 5 99.84 Very High Very High Very High
Neuropathic pain 6 99.36 Very High Very High Very High
agonist 4 99.34 Very High Very High Very High
Dorsal horn 1 99.30 Very High Very High Very High
qutenza 8 99.16 Very High Very High Very High
Nucleus accumbens 2 99.12 Very High Very High Very High
Opioid 7 98.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 8 99.36 Very High Very High Very High
Sprains And Strains 13 99.32 Very High Very High Very High
Injury 5 99.12 Very High Very High Very High
Nociception 3 92.16 High High
Depression 6 91.64 High High
Nervous System Injury 1 88.40 High High
Depressive Disorder 1 86.56 High High
Lordosis 3 81.20 Quite High
Pain 5 79.72 Quite High
Cough 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, Y1 mRNA levels tended to be decreased by fluoxetine in the nucleus accumbens of the FSL rats, but increased in the FRL.
Negative_regulation (decreased) of Y1 in nucleus accumbens associated with nucleus accumbens and fluoxetine
1) Confidence 0.45 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9729278 Disease Relevance 0.48 Pain Relevance 0.83
In this study, we evaluated the hypothesis that agonists at the NPY Y1 receptor subtype (Y1-R) inhibit exocytosis from the capsaicin-sensitive class of nociceptors.
Negative_regulation (inhibit) of Y1-R in nociceptors associated with qutenza, nociceptor and agonist
2) Confidence 0.39 Published 2004 Journal Neuroscience Section Abstract Doc Link 15099684 Disease Relevance 0.18 Pain Relevance 0.86
The Y1R antagonist (Cys31, Nva34)-Neuropeptide Y (27-36)2 prevented estrogen-induced Y1R and MOR activation/internalization.
Negative_regulation (prevented) of Y1R associated with antagonist and neuropeptide
3) Confidence 0.38 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14749439 Disease Relevance 0.15 Pain Relevance 0.49
We also monitored changes in the expression of neuropeptide Y (NPY) and the NPY Y1 receptor (Y1R) in the lumbar 4-5 dorsal root ganglia (DRG) and dorsal horn and found upregulation of NPY and downregulation of the Y1R in DRG neurons after injury.
Negative_regulation (downregulation) of Y1R in DRG associated with injury, dorsal horn and neuropeptide
4) Confidence 0.33 Published 2004 Journal Brain Res. Section Abstract Doc Link 15047027 Disease Relevance 0.55 Pain Relevance 0.55
This analgesic effect of 26RFa on the phase 1 response, but not phase 2 response, was antagonized by BIBP3226, a mixed antagonist of neuropeptide Y Y1 and neuropeptide FF receptors.
Negative_regulation (antagonist) of Y Y1 associated with antagonist, analgesic and neuropeptide
5) Confidence 0.24 Published 2009 Journal Peptides Section Abstract Doc Link 19520126 Disease Relevance 0.15 Pain Relevance 0.85
Opioid-like actions of neuropeptide Y in rat substantia gelatinosa: Y1 suppression of inhibition and Y2 suppression of excitation.
Negative_regulation (suppression) of Y1 in substantia gelatinosa associated with substantia gelatinosa, neuropeptide and opioid
6) Confidence 0.20 Published 2004 Journal J. Neurophysiol. Section Title Doc Link 15295007 Disease Relevance 0.28 Pain Relevance 1.18
Opioid-like actions of neuropeptide Y in rat substantia gelatinosa: Y1 suppression of inhibition and Y2 suppression of excitation.
Negative_regulation (suppression) of Y1 in substantia gelatinosa associated with substantia gelatinosa, neuropeptide and opioid
7) Confidence 0.20 Published 2004 Journal J. Neurophysiol. Section Title Doc Link 15295007 Disease Relevance 0.29 Pain Relevance 1.20
We find that NLH rats have approximately a 30-35% decrease in basal hippocampal NPY mRNA compared with SD and LH rats.
Negative_regulation (decrease) of NPY mRNA associated with sprains and strains
8) Confidence 0.16 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1353857 Disease Relevance 0.78 Pain Relevance 0.26
The kinetic data of the modified FC5 and FC45 sequences discussed in later sections are also reported in Table 2.
Negative_regulation (reported) of FC5
9) Confidence 0.13 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1636496 Disease Relevance 0 Pain Relevance 0.33
NPY inhibited Ca2+ currents (ICa) via a Y1 receptor in 84% of acutely isolated DGCs and via a Y2 receptor in 31% of the NPY-responsive cells tested.
Negative_regulation (inhibited) of Y1 receptor in DGCs
10) Confidence 0.10 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8778293 Disease Relevance 0 Pain Relevance 0.17

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