INT76651

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Context Info
Confidence 0.08
First Reported 1998
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cpe, Il6) extracellular region (Cpe, Il6) peptidase activity (Cpe)
Golgi apparatus (Cpe)
Anatomy Link Frequency
plasma 2
Cpe (Mus musculus)
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 16 100.00 Very High Very High Very High
Opioid 4 96.08 Very High Very High Very High
Inflammatory response 2 88.16 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
First an increase in met-enkephalin plasma levels occurred (8.9+/-2.9 to 135+/-18 pg/ml; P<0.005), and then an increase in plasma IL-6 levels (2.1+/-1.5 to 237+/-50 pg/ml; P<0.001), suggesting that, as in mice, met-enkephalin induces IL-6 production.
met-enkephalin Positive_regulation (induces) of Gene_expression (production) of IL-6 in plasma associated with enkephalin
1) Confidence 0.08 Published 1998 Journal Int. J. Cardiol. Section Abstract Doc Link 9687093 Disease Relevance 0 Pain Relevance 0.88
We demonstrate that methionine-enkephalin (met-enkephalin) stimulates IL-6 mRNA expression in mice as determined by RNA isolation and hybridization with IL-6 cDNA.
met-enkephalin Positive_regulation (stimulates) of Gene_expression (expression) of IL-6 associated with enkephalin
2) Confidence 0.06 Published 1998 Journal Int. J. Cardiol. Section Abstract Doc Link 9687093 Disease Relevance 0 Pain Relevance 0.68

General Comments

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