INT76660

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Context Info
Confidence 0.78
First Reported 1998
Last Reported 2011
Negated 20
Speculated 18
Reported most in Abstract
Documents 691
Total Number 716
Disease Relevance 329.46
Pain Relevance 386.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) transport (Trpv1) plasma membrane (Trpv1)
transmembrane transport (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
neurons 142
sensory neurons 34
neuronal 22
nociceptors 21
primary sensory neurons 18
Trpv1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 13840 100.00 Very High Very High Very High
opioid receptor 6669 100.00 Very High Very High Very High
Pain 6584 100.00 Very High Very High Very High
dorsal root ganglion 5868 100.00 Very High Very High Very High
nociceptor 3592 100.00 Very High Very High Very High
agonist 2740 100.00 Very High Very High Very High
antagonist 2316 100.00 Very High Very High Very High
Spinal cord 1449 100.00 Very High Very High Very High
Opioid 1151 100.00 Very High Very High Very High
c fibre 1070 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 10456 100.00 Very High Very High Very High
Targeted Disruption 3993 100.00 Very High Very High Very High
Nociception 3614 100.00 Very High Very High Very High
Death 418 100.00 Very High Very High Very High
Bladder Cancer 25 100.00 Very High Very High Very High
INFLAMMATION 6977 99.88 Very High Very High Very High
Diabetes Mellitus 6562 99.88 Very High Very High Very High
Pain 6806 99.84 Very High Very High Very High
Peripheral Neuropathy 1021 99.84 Very High Very High Very High
Obesity 87 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The vanilloid receptor (TRPV1) is a member of the transient receptor potential family of ion channels that is highly expressed in nociceptive primary afferent sensory neurons.
Gene_expression (expressed) of vanilloid receptor in sensory neurons associated with nociception
1) Confidence 0.78 Published 2006 Journal Recent patents on CNS drug discovery Section Abstract Doc Link 18221192 Disease Relevance 0.44 Pain Relevance 0.46
The vanilloid receptor (TRPV1) is a member of the transient receptor potential family of ion channels that is highly expressed in nociceptive primary afferent sensory neurons.
Gene_expression (expressed) of TRPV1 in sensory neurons associated with nociception
2) Confidence 0.78 Published 2006 Journal Recent patents on CNS drug discovery Section Abstract Doc Link 18221192 Disease Relevance 0.44 Pain Relevance 0.46
The present review summarizes the properties of the TRPV1 ion channel known to be expressed in lung C-fibre afferents, the possible role of TRPV1 in respiratory sensation and neurogenic inflammation, as well as the limitations and opportunities associated with current TRPV1 antagonists.
Gene_expression (expressed) of TRPV1 in respiratory associated with c fibre, inflammation, antagonist and neurogenic inflammation
3) Confidence 0.78 Published 2009 Journal Respir Physiol Neurobiol Section Abstract Doc Link 19450765 Disease Relevance 0.84 Pain Relevance 0.51
Recent advances in pain biology such as the cloning of the transient receptor potential vanilloid 1 (TRPV1) ion channel, exploration of the molecular mechanisms leading to TRPV1 activation and the production of a TRPV1 mutant mouse have defined its role as an integrator of noxious thermal and chemical stimuli.
Gene_expression (production) of TRPV1 associated with pain
4) Confidence 0.78 Published 2009 Journal Respir Physiol Neurobiol Section Abstract Doc Link 19450765 Disease Relevance 0.90 Pain Relevance 0.49
The capsaicin receptor TRPV1 (transient receptor potential vanilloid subtype 1) is a cation channel expressed by nociceptors that detects multiple pain-producing stimuli, including noxious heat and extracellular protons, raising the possibility that it is an important mediator of bone cancer pain via its capacity to detect osteoclast- and tumor-mediated tissue acidosis.
Gene_expression (expressed) of TRPV1 in nociceptors associated with pain, cancer pain, qutenza, acidosis, nociceptor, cancer, tissue acidosis and bone cancer
5) Confidence 0.78 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15788769 Disease Relevance 0.88 Pain Relevance 0.95
The transient receptor potential vanilloid 1 receptor (TRPV1) is expressed predominantly in a subset of primary afferent nociceptors.
Gene_expression (expressed) of vanilloid 1 receptor in nociceptors associated with nociceptor
6) Confidence 0.78 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17312187 Disease Relevance 0.13 Pain Relevance 0.41
The transient receptor potential vanilloid 1 receptor (TRPV1) is expressed predominantly in a subset of primary afferent nociceptors.
Gene_expression (expressed) of TRPV1 in nociceptors associated with nociceptor
7) Confidence 0.78 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17312187 Disease Relevance 0.13 Pain Relevance 0.41
If so, it is conceivable that such TRPV1 ligands can be synthesized that specifically target TRPV1 in diseased (e.g. inflamed or neoplastic) tissues but spare TRPV1 that subserves its physiological functions in healthy organs.
Gene_expression (synthesized) of TRPV1
8) Confidence 0.78 Published 2006 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 16773387 Disease Relevance 0 Pain Relevance 0.21
Increased expression of vanilloid receptor 1 on myelinated primary afferent neurons contributes to the antihyperalgesic effect of capsaicin cream in diabetic neuropathic pain in mice.
Gene_expression (expression) of vanilloid receptor 1 in afferent neurons associated with antihyperalgesic, qutenza, diabetes mellitus and neuropathic pain
9) Confidence 0.78 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 12724350 Disease Relevance 0.98 Pain Relevance 1.40
Here, we report that an up-regulation of VR1 expression on myelinated fibers contributes to the antihyperalgesic effect of capsaicin cream in streptozotocin (STZ)-induced diabetic neuropathic pain.
Gene_expression (expression) of VR1 associated with antihyperalgesic, qutenza, diabetes mellitus and neuropathic pain
10) Confidence 0.78 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12724350 Disease Relevance 0.78 Pain Relevance 0.87
Finally, we confirmed the up-regulation of VR1 expression on myelinated primary afferent neurons of diabetic mice by immunohistochemistry.
Gene_expression (expression) of VR1 in afferent neurons associated with diabetes mellitus
11) Confidence 0.78 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12724350 Disease Relevance 1.01 Pain Relevance 1.46
TRPV1, the capsaicin receptor, is expressed not only in nociceptive neurons, but also in other locations, including the hypothalamus.
Gene_expression (expressed) of TRPV1 in hypothalamus associated with nociception and qutenza
12) Confidence 0.78 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15763167 Disease Relevance 0.29 Pain Relevance 0.22
TRPV1, the capsaicin receptor, is expressed not only in nociceptive neurons, but also in other locations, including the hypothalamus.
Gene_expression (expressed) of capsaicin receptor in hypothalamus associated with nociception and qutenza
13) Confidence 0.78 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15763167 Disease Relevance 0.29 Pain Relevance 0.22
In the urinary bladder, the capsaicin-gated ion channel TRPV1 is expressed both within afferent nerve terminals and within the epithelial cells that line the bladder lumen.
Gene_expression (expressed) of TRPV1 in epithelial cells associated with qutenza
14) Confidence 0.78 Published 2002 Journal Nat. Neurosci. Section Abstract Doc Link 12161756 Disease Relevance 0.30 Pain Relevance 0.20
We summarize disease-related changes in TRPV1 expression and its implications for therapy and potential adverse effects.
Gene_expression (expression) of TRPV1 associated with disease
15) Confidence 0.78 Published 2008 Journal Clin J Pain Section Abstract Doc Link 18209521 Disease Relevance 0.27 Pain Relevance 0.47
Heterologously expressed VR1 can be activated by vanilloid compounds, protons, or heat (>43 degrees C), but whether this channel contributes to chemical or thermal sensitivity in vivo is not known.
Spec (whether) Gene_expression (expressed) of VR1
16) Confidence 0.78 Published 2000 Journal Science Section Abstract Doc Link 10764638 Disease Relevance 0.43 Pain Relevance 0.56
In patch-clamp experiments, capsiate was found to activate TRPV1 expressed transiently in HEK293 cells with a similar potency as capsaicin.
Gene_expression (expressed) of TRPV1 associated with qutenza and potency
17) Confidence 0.78 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12726827 Disease Relevance 0.17 Pain Relevance 0.61
The vanilloid receptor-1 (VR1) is a ligand-gated, non-selective cation channel expressed predominantly by sensory neurons.
Gene_expression (expressed) of vanilloid receptor-1 in sensory neurons
18) Confidence 0.78 Published 2000 Journal Nature Section Abstract Doc Link 10821274 Disease Relevance 0.35 Pain Relevance 0.51
The vanilloid receptor-1 (VR1) is a ligand-gated, non-selective cation channel expressed predominantly by sensory neurons.
Gene_expression (expressed) of VR1 in sensory neurons
19) Confidence 0.78 Published 2000 Journal Nature Section Abstract Doc Link 10821274 Disease Relevance 0.35 Pain Relevance 0.51
In response to I-RTX in vitro, HEK293 cells expressing rat TRPV1 exhibited increases in intracellular Ca(2+) (biphasic, EC(50) = 56.7 nM and 9.9 microM) that depended on Ca(2+) influx and outwardly rectifying, capsazepine-sensitive currents that were smaller than those evoked by 1 microM capsaicin.
Gene_expression (expressing) of TRPV1 associated with qutenza
20) Confidence 0.78 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15947039 Disease Relevance 0.07 Pain Relevance 0.50

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