INT7667

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Context Info
Confidence 0.60
First Reported 1992
Last Reported 2010
Negated 4
Speculated 5
Reported most in Abstract
Documents 28
Total Number 34
Disease Relevance 16.65
Pain Relevance 16.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npy) extracellular region (Npy)
Anatomy Link Frequency
neurons 8
arcuate nucleus 6
dorsal root ganglia 5
locus coeruleus 3
sensory neurons 3
Npy (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 214 100.00 Very High Very High Very High
Neuropeptide 89 100.00 Very High Very High Very High
Calcitonin gene-related peptide 30 100.00 Very High Very High Very High
Enkephalin 12 100.00 Very High Very High Very High
qutenza 11 100.00 Very High Very High Very High
Somatostatin 10 100.00 Very High Very High Very High
antidepressant 8 100.00 Very High Very High Very High
Opioid 7 100.00 Very High Very High Very High
Acupuncture 6 100.00 Very High Very High Very High
Sciatic nerve 39 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 217 100.00 Very High Very High Very High
Aids-related Complex 130 100.00 Very High Very High Very High
Obesity 20 100.00 Very High Very High Very High
Injury 45 99.82 Very High Very High Very High
Nervous System Injury 87 99.74 Very High Very High Very High
Sprains And Strains 9 98.88 Very High Very High Very High
Diabetes Mellitus 9 98.52 Very High Very High Very High
Stress 24 96.96 Very High Very High Very High
Drug Dependence 2 96.72 Very High Very High Very High
Neuropathic Pain 20 96.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To examine further the relationship between the NAL-induced increase in LH release and increase in NPY gene expression, the effects of NPY mRNA antisense oligonucleotides (oligos) on NPY levels in the ME-ARC and on plasma LH levels were studied in NAL-infused rats.
Regulation (effects) of Gene_expression (levels) of NPY in plasma associated with aids-related complex and narcan
1) Confidence 0.60 Published 1996 Journal Endocrinology Section Abstract Doc Link 8536645 Disease Relevance 0.27 Pain Relevance 0.64
In this study, we examined the regulation of NPY gene expression in the arcuate nucleus in hypothalamic organotypic cultures.
Spec (examined) Regulation (regulation) of Gene_expression (expression) of NPY gene in arcuate nucleus
2) Confidence 0.60 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16177033 Disease Relevance 0 Pain Relevance 0.65
Taken together, our results demonstrate that the activation of ERK and p38 and also the changes in NPY and BDNF expression may occur in different populations of DRG neurons after CCI, partially through alterations in the target-derived NGF.
Regulation (changes) of Gene_expression (expression) of NPY in neurons associated with dorsal root ganglion, nerve growth factor and eae
3) Confidence 0.60 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15579142 Disease Relevance 1.29 Pain Relevance 1.10
Effect of peripheral 2-DG on opioid and neuropeptide Y gene expression.
Regulation (Effect) of Gene_expression (expression) of neuropeptide Y gene associated with neuropeptide, enkephalin and opioid
4) Confidence 0.58 Published 1998 Journal Brain Res. Section Title Doc Link 9593862 Disease Relevance 0.17 Pain Relevance 0.38
Effects of long-term treatment with antidepressant drugs on proopiomelanocortin and neuropeptide Y mRNA expression in the hypothalamic arcuate nucleus of rats.
Regulation (Effects) of Gene_expression (expression) of neuropeptide Y in arcuate nucleus associated with antidepressant and neuropeptide
5) Confidence 0.45 Published 1996 Journal J. Neuroendocrinol. Section Title Doc Link 8736433 Disease Relevance 0.35 Pain Relevance 0.35
They also showed little or no change in staining for NPY, acetylcholinesterase (AChE) and tyrosine hydroxylase (TH) and essentially normal striatal gross morphology.
Neg (little) Regulation (change) of Gene_expression (staining) of NPY
6) Confidence 0.44 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10648885 Disease Relevance 0 Pain Relevance 0.27
Dexamethasone (DEX) (10(-9) to 10(-7) M) significantly increased NPY mRNA expression, and the effects were not influenced by coincubation with the sodium channel blocker tetrodotoxin (TTX), indicating that the action of DEX is independent of action potentials.
Neg (not) Regulation (influenced) of Gene_expression (expression) of NPY associated with action potential, tetrodotoxin, sodium channel and dexamethasone
7) Confidence 0.44 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16177033 Disease Relevance 0 Pain Relevance 0.80
Furthermore, the number of c-Fos-LI cells as well as the percentage of c-Fos-LI cuneothalamic projection neurons (CTNs) in the CN was markedly decreased after injection of NPY receptor antagonist along with retrograde tract-tracing method, indicating that NPY regulated c-Fos expression.
Regulation (regulated) of Gene_expression (expression) of NPY in CTNs associated with antagonist and projection neuron
8) Confidence 0.44 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19456245 Disease Relevance 0.61 Pain Relevance 0.67
In situ hybridization and immunocytochemistry were applied to investigate changes in the expression of somatostatin, neuropeptide Y, neurokinin B, cholecystokinin, dynorphin, and Met-enkephalin in the rat hippocampus after administration of a single peroral dose of trimethyltin hydroxide (9 mg/kg).
Spec (investigate) Regulation (changes) of Gene_expression (expression) of neuropeptide Y in hippocampus associated with dynorphin, neuropeptide, somatostatin, hippocampus, enkephalin and cholecystokinin
9) Confidence 0.44 Published 1998 Journal Synapse Section Abstract Doc Link 9661251 Disease Relevance 0.29 Pain Relevance 0.51
The data suggest that the regulation of NPY gene expression may be involved in the reduced vulnerability of NLH rats to develop learned helplessness.
Regulation (regulation) of Gene_expression (expression) of NPY gene associated with sprains and strains
10) Confidence 0.41 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1353857 Disease Relevance 0.82 Pain Relevance 0.24
These results indicate that reduced food intake affects the expression of NPY, Gal and Leu-enk not only in the relevant hypothalamic neuroendocrine centres, but also in the lateral septal area.
Regulation (affects) of Gene_expression (expression) of NPY in septal area
11) Confidence 0.39 Published 2005 Journal Acta. Biol. Hung. Section Abstract Doc Link 16196194 Disease Relevance 0 Pain Relevance 0.04
Our results show a severalfold increase in the relative abundance of TH and NPY mRNAs in response to a single immobilization.
Regulation (response) of Gene_expression (abundance) of NPY
12) Confidence 0.33 Published 1996 Journal Endocrinology Section Abstract Doc Link 8940389 Disease Relevance 0.56 Pain Relevance 0.28
It is known that neuropeptide Y (NPY) is expressed at very low levels in DRG neurons of normal rats, but its expression is markedly up-regulated in large DRG neurons after peripheral nerve injury [38,39].
Regulation (regulated) of Gene_expression (expressed) of NPY in neurons associated with dorsal root ganglion, nervous system injury, neuropeptide and peripheral nerve injury
13) Confidence 0.32 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 1.72 Pain Relevance 1.03
The down-regulated expression of CGRP and IB4 in small DRG neurons, and the up-regulated expression of NPY in large DRG neurons became predominant 14 days after sciatic nerve axotomy (Fig. 7A), consistent with previous studies [38,39].
Regulation (regulated) of Gene_expression (expression) of NPY in IB4 associated with dorsal root ganglion, sciatic nerve and calcitonin gene-related peptide
14) Confidence 0.32 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 1.58 Pain Relevance 0.98
In the present study, the effect of acupuncture stimulation at Zusanli (St.36) on NPY expression in the Streptozotocin (STZ)-induced diabetic rats was investigated via immunohistochemistry.
Spec (investigated) Regulation (effect) of Gene_expression (expression) of NPY associated with diabetes mellitus and acupuncture
15) Confidence 0.27 Published 2004 Journal Acupunct Electrother Res Section Abstract Doc Link 15382790 Disease Relevance 0.33 Pain Relevance 0.37
In this review we concentrate on this important aspect of NPY pharmacology and consider mechanisms controlling the expression of NPY and its receptors.
Regulation (controlling) of Gene_expression (expression) of NPY
16) Confidence 0.27 Published 1996 Journal Drugs Section Abstract Doc Link 8875128 Disease Relevance 0.26 Pain Relevance 0.51
CONCLUSION: Symptoms of neuropathic pain improved and expression of NPY in the brain was increased in CCI model rats after ECS, suggesting that changes in the expression of NPY in the brain may be related to the mechanism of action of ECT in treating neuropathic pain.


Regulation (changes) of Gene_expression (expression) of NPY in brain
17) Confidence 0.27 Published 2009 Journal Pain Med Section Body Doc Link 19671088 Disease Relevance 0.17 Pain Relevance 0
We also monitored changes in the expression of neuropeptide Y (NPY) and the NPY Y1 receptor (Y1R) in the lumbar 4-5 dorsal root ganglia (DRG) and dorsal horn and found upregulation of NPY and downregulation of the Y1R in DRG neurons after injury.
Regulation (changes) of Gene_expression (expression) of NPY in DRG associated with injury, dorsal horn and neuropeptide
18) Confidence 0.27 Published 2004 Journal Brain Res. Section Abstract Doc Link 15047027 Disease Relevance 0.46 Pain Relevance 0.49
Bone marrow stromal cells attenuate injury-induced changes in galanin, NPY and NPY Y1-receptor expression after a sciatic nerve constriction.
Regulation (changes) of Gene_expression (expression) of NPY in sciatic nerve associated with injury and sciatic nerve
19) Confidence 0.27 Published 2009 Journal Neuropeptides Section Title Doc Link 19168218 Disease Relevance 0.34 Pain Relevance 0.44
Altered expression of NPY in the basolateral amygdala and locus coeruleus could contribute to or compensate for behavioural and autonomic sensitisation in preshocked rats.
Regulation (Altered) of Gene_expression (expression) of NPY in locus coeruleus associated with locus ceruleus and amygdala
20) Confidence 0.26 Published 2008 Journal Brain Res. Section Abstract Doc Link 18440496 Disease Relevance 0.26 Pain Relevance 0.59

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