INT76672

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Context Info
Confidence 0.15
First Reported 1998
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.24
Pain Relevance 3.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

GPM6A (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 85 99.96 Very High Very High Very High
analgesia 5 98.44 Very High Very High Very High
Pain 9 98.24 Very High Very High Very High
opioid receptor 4 96.04 Very High Very High Very High
Analgesic 4 76.52 Quite High
antinociception 2 75.00 Quite High
agonist 1 72.52 Quite High
Opioid 6 69.12 Quite High
Potency 1 62.60 Quite High
Oxycodone 43 58.76 Quite High
Disease Link Frequency Relevance Heat
Pain 8 98.24 Very High Very High Very High
Cancer 1 90.56 High High
Disorders Of Creatine Metabolism 2 5.00 Very Low Very Low Very Low
Respiratory Failure 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Hypersensitivity 1 5.00 Very Low Very Low Very Low
Post Operative Pain 1 5.00 Very Low Very Low Very Low
Mental Disorders 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alterations in the M6G/morphine system may have clinically significant pharmacodynamic consequences.
Regulation (Alterations) of M6G associated with morphine
1) Confidence 0.15 Published 2002 Journal J Clin Pharmacol Section Abstract Doc Link 12017351 Disease Relevance 0.05 Pain Relevance 1.18
In contrast, ranitidine had no significant effect on the urinary M3G/M6G ratio.
Neg (no) Regulation (effect) of M6G
2) Confidence 0.05 Published 1998 Journal Hum Exp Toxicol Section Abstract Doc Link 9688360 Disease Relevance 0 Pain Relevance 1.19
Sawyer et al saw an effect on M3G and M6G-concentrations in patients with variations in the uridine diphosphate-glucuronosyltransferase (by UGT2B7*2), which indicates that inter-individual differences in morphine glucuronidation may be the result of genetic variation (Saywer et al 2003).
Regulation (effect) of M6G associated with morphine
3) Confidence 0.03 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376067 Disease Relevance 0.19 Pain Relevance 1.23

General Comments

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