INT76672

Context Info Confidence 0.15 First Reported 1998 Last Reported 2007 Negated 1 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 0.24 Pain Relevance 3.60

GPM6A (Homo sapiens)

Pain Link Frequency Relevance Heat Morphine 85 99.96 analgesia 5 98.44 Pain 9 98.24 opioid receptor 4 96.04 Analgesic 4 76.52 antinociception 2 75.00 agonist 1 72.52 Opioid 6 69.12 Potency 1 62.60 Oxycodone 43 58.76

Disease Link Frequency Relevance Heat Pain 8 98.24 Cancer 1 90.56 Disorders Of Creatine Metabolism 2 5.00 Respiratory Failure 1 5.00 Osteoarthritis 1 5.00 Hypersensitivity 1 5.00 Post Operative Pain 1 5.00 Mental Disorders 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Alterations in the M6G/morphine system may have clinically significant pharmacodynamic consequences.

Regulation (Alterations) of M6G associated with morphine

1) Confidence 0.15 Published 2002 Journal J Clin Pharmacol Section Abstract Doc Link 12017351 Disease Relevance 0.05 Pain Relevance 1.18

In contrast, ranitidine had no significant effect on the urinary M3G/M6G ratio.

Neg (no) Regulation (effect) of M6G

2) Confidence 0.05 Published 1998 Journal Hum Exp Toxicol Section Abstract Doc Link 9688360 Disease Relevance 0 Pain Relevance 1.19

Sawyer et al saw an effect on M3G and M6G-concentrations in patients with variations in the uridine diphosphate-glucuronosyltransferase (by UGT2B7*2), which indicates that inter-individual differences in morphine glucuronidation may be the result of genetic variation (Saywer et al 2003).

Regulation (effect) of M6G associated with morphine

3) Confidence 0.03 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376067 Disease Relevance 0.19 Pain Relevance 1.23

General Comments

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