INT76680

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Context Info
Confidence 0.24
First Reported 1998
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 4.50
Pain Relevance 3.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Il1rap) intracellular (Il1rap) protein binding, bridging (Il1rap)
protein complex (Il1rap) signal transducer activity (Il1rap)
Anatomy Link Frequency
sensory neurons 1
hypothalamus 1
neurons 1
cortex 1
Il1rap (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 9 99.96 Very High Very High Very High
cytokine 31 99.64 Very High Very High Very High
Inflammation 13 99.46 Very High Very High Very High
substance P 24 96.72 Very High Very High Very High
Neuropathic pain 29 96.32 Very High Very High Very High
allodynia 8 95.36 Very High Very High Very High
Peripheral nerve injury 2 91.12 High High
Neuropeptide 9 85.40 High High
COX2 1 85.28 High High
Opioid 2 83.92 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 16 99.46 Very High Very High Very High
Neuropathic Pain 40 96.32 Very High Very High Very High
Cancer 24 92.80 High High
Appetite Loss 14 92.44 High High
Nervous System Injury 15 91.12 High High
Necrosis 4 78.56 Quite High
Inflammatory Pain 1 75.76 Quite High
Prostate Cancer 6 75.00 Quite High
Pain 16 73.24 Quite High
Nociception 8 73.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of DRG neurons in culture with herbimycin A, genistein or PP2, three structurally different nonreceptor tyrosine kinase inhibitors that act by different mechanisms, decreased the kinase activity of p60c-src induced by the activation of IL-1 receptor.
Positive_regulation (activation) of IL-1 receptor in neurons
1) Confidence 0.24 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622206 Disease Relevance 0.07 Pain Relevance 0.42
These findings show that phosphorylation of specific protein tyrosine residue(s) following IL-1 receptor activation might play a key role in IL-1beta signalling to modulate PPT gene expression and SP secretion in sensory neurons.
Positive_regulation (activation) of IL-1 receptor in sensory neurons associated with substance p
2) Confidence 0.17 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622206 Disease Relevance 0 Pain Relevance 0.45
IL-1 receptor antagonist (IL-1Ra) mRNA and IL-1 receptor type I mRNA levels were also significantly increased in the cortex and hypothalamus.
Positive_regulation (increased) of IL-1 receptor type I mRNA in cortex associated with antagonist
3) Confidence 0.16 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9688694 Disease Relevance 1.58 Pain Relevance 0.43
IL-4 is a prototypical anti-inflammatory cytokine that is known to increase IL-1 receptor antagonist mRNA and protein, and to suppress the expression of IL-1?
Positive_regulation (increase) of IL-1 receptor associated with inflammation, antagonist and cytokine
4) Confidence 0.06 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395302 Disease Relevance 1.28 Pain Relevance 1.47
IL-1 receptor antagonist (IL-1Ra) mRNA and IL-1 receptor type I mRNA levels were also significantly increased in the cortex and hypothalamus.
Positive_regulation (increased) of IL-1 receptor type I mRNA in hypothalamus associated with antagonist
5) Confidence 0.06 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9688694 Disease Relevance 1.58 Pain Relevance 0.43

General Comments

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