INT76681

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Context Info
Confidence 0.25
First Reported 1998
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 4.46
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Il1rap) intracellular (Il1rap) protein binding, bridging (Il1rap)
protein complex (Il1rap) signal transducer activity (Il1rap)
Anatomy Link Frequency
dorsal 1
hypothalamus 1
cortex 1
Il1rap (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 5 99.96 Very High Very High Very High
Spinal cord 3 98.44 Very High Very High Very High
intrathecal 2 97.24 Very High Very High Very High
cytokine 17 93.84 High High
Pain 7 91.88 High High
Neuropeptide 8 85.40 High High
Opioid 2 83.92 Quite High
allodynia 4 82.52 Quite High
Inflammation 2 75.20 Quite High
Sciatic nerve 1 73.80 Quite High
Disease Link Frequency Relevance Heat
Cancer 23 100.00 Very High Very High Very High
Necrosis 3 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 97.32 Very High Very High Very High
Appetite Loss 14 92.44 High High
Pain 7 91.88 High High
Neuropathic Pain 6 82.52 Quite High
INFLAMMATION 2 75.20 Quite High
Prostate Cancer 6 75.00 Quite High
Disease 2 62.80 Quite High
Neurologic Manifestations 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-1 receptor antagonist (IL-1Ra) mRNA and IL-1 receptor type I mRNA levels were also significantly increased in the cortex and hypothalamus.
Transcription (levels) of IL-1 receptor type I mRNA in cortex associated with antagonist
1) Confidence 0.25 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9688694 Disease Relevance 1.56 Pain Relevance 0.43
In a model of spinal immune activation by intrathecal HIV-1 gp120, we show that the anti-allodynic effects of minocycline are associated with decreased microglial activation, attenuated mRNA expression of interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), IL-1beta-converting enzyme, TNF-alpha-converting enzyme, IL-1 receptor antagonist and IL-10 in lumbar dorsal spinal cord, and reduced IL-1beta and TNF-alpha levels in the CSF.
Transcription (expression) of IL-1 receptor in dorsal associated with necrosis, cancer, antagonist, acquired immune deficiency syndrome or hiv infection, spinal cord and intrathecal
2) Confidence 0.25 Published 2005 Journal Pain Section Abstract Doc Link 15836971 Disease Relevance 1.34 Pain Relevance 1.32
IL-1 receptor antagonist (IL-1Ra) mRNA and IL-1 receptor type I mRNA levels were also significantly increased in the cortex and hypothalamus.
Transcription (levels) of IL-1 receptor type I mRNA in hypothalamus associated with antagonist
3) Confidence 0.08 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9688694 Disease Relevance 1.56 Pain Relevance 0.43

General Comments

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