INT767

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Context Info
Confidence 0.80
First Reported 1975
Last Reported 2010
Negated 1
Speculated 4
Reported most in Abstract
Documents 565
Total Number 569
Disease Relevance 106.68
Pain Relevance 214.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gnrhr) signal transducer activity (Gnrhr)
Anatomy Link Frequency
pituitary 35
anterior pituitary 15
hypothalamus 14
plasma 12
thyroid 11
Gnrhr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 715 100.00 Very High Very High Very High
Somatostatin 657 100.00 Very High Very High Very High
Morphine 475 100.00 Very High Very High Very High
Fibrositis 410 100.00 Very High Very High Very High
opiate 221 100.00 Very High Very High Very High
tolerance 89 100.00 Very High Very High Very High
Catecholamine 62 100.00 Very High Very High Very High
corticosteroid 17 100.00 Very High Very High Very High
agonist 411 99.96 Very High Very High Very High
Neurotransmitter 108 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 483 100.00 Very High Very High Very High
Fibromyalgia 368 100.00 Very High Very High Very High
Growth Hormone Deficiency 47 100.00 Very High Very High Very High
Galactorrhea 26 100.00 Very High Very High Very High
Reprotox - General 1 19 100.00 Very High Very High Very High
Growth Hormone-secreting Pituitary Adenoma 1 100.00 Very High Very High Very High
Pituitary Cancer 53 99.98 Very High Very High Very High
Cancer 76 99.96 Very High Very High Very High
Sleep Disorders 59 99.96 Very High Very High Very High
Body Weight 52 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate the mechanisms subserving the reported reduced pulsatile release of gonadotropin-releasing hormone (GnRH) in chronic renal failure, this study examined the amino acid neurotransmitter milieu in the medial preoptic area (MPOA), the hypothalamic region where the GnRH-secreting neurons reside, in 5/6-nephrectomized male rats and in ad libitum-fed or pair-fed controls.
Localization (release) of gonadotropin-releasing hormone in medial associated with neurotransmitter, chronic renal failure and urological neuroanatomy
1) Confidence 0.80 Published 2001 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 11373345 Disease Relevance 0.71 Pain Relevance 0.15
[The effect of anesthetics on the basal secretion of immunoreactive growth hormone in rats].
Localization (secretion) of immunoreactive growth hormone
2) Confidence 0.80 Published 1978 Journal C.R. Hebd. Seances Acad. Sci., Ser. D, Sci. Nat. Section Title Doc Link 100239 Disease Relevance 0.08 Pain Relevance 0.08
Functional subsensitivity of 5-hydroxytryptamine1C or alpha 2 adrenergic heteroreceptors mediating clonidine-induced growth hormone release in the Fawn-Hooded rat strain relative to the Wistar rat strain.
Localization (release) of growth hormone associated with sprains and strains and clonidine
3) Confidence 0.79 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 1356149 Disease Relevance 0.25 Pain Relevance 1.01
It is well documented that gonadotropin-releasing hormone (GnRH) release is negatively regulated by opiates.
Localization (release) of gonadotropin-releasing hormone associated with opiate
4) Confidence 0.79 Published 1993 Journal Neuroreport Section Abstract Doc Link 8477057 Disease Relevance 0 Pain Relevance 0.78
We studied the response of growth hormone secretion after the administration of L-dopa, clonidine, and growth hormone releasing hormone in eight growth-retarded children with Down syndrome aged 1 to 6.5 years.
Localization (secretion) of growth hormone associated with down syndrome and clonidine
5) Confidence 0.78 Published 1993 Journal Res Dev Disabil Section Abstract Doc Link 8210606 Disease Relevance 0.17 Pain Relevance 0.25
Most of the children had a modified response of growth hormone secretion subsequent to the various stimulation tests.
Localization (secretion) of growth hormone
6) Confidence 0.78 Published 1993 Journal Res Dev Disabil Section Abstract Doc Link 8210606 Disease Relevance 0.22 Pain Relevance 0.31
After L-dopa administration, five children had low growth hormone secretion (M = 3.7 ng/ml, SD = 2.12 at 30 min) and three children had elevated growth hormone levels (> 30 ng/ml).
Localization (secretion) of growth hormone
7) Confidence 0.78 Published 1993 Journal Res Dev Disabil Section Abstract Doc Link 8210606 Disease Relevance 0.17 Pain Relevance 0.26
However, there is increasing appreciation that suboptimal growth hormone secretion, leading to a state of adult growth hormone deficiency, may occur in the setting of chronic inflammatory disease, chronic corticosteroid use, and fibromyalgia.
Localization (secretion) of growth hormone associated with corticosteroid, inflammation, disease, growth hormone deficiency and fibrositis
8) Confidence 0.78 Published 2004 Journal Curr Rheumatol Rep Section Abstract Doc Link 15251074 Disease Relevance 0.65 Pain Relevance 0.22
Therefore, the evaluation and effective management of growth hormone oversecretion and undersecretion is relevant to practicing rheumatologists.
Localization (oversecretion) of growth hormone
9) Confidence 0.78 Published 2004 Journal Curr Rheumatol Rep Section Abstract Doc Link 15251074 Disease Relevance 0.63 Pain Relevance 0.22
Growth hormone release in normal children after oral clonidine 4 micrograms/kg.
Localization (release) of Growth hormone associated with clonidine
10) Confidence 0.78 Published 1989 Journal J Med Assoc Thai Section Title Doc Link 2732653 Disease Relevance 0 Pain Relevance 0.43
Therefore, the evaluation and effective management of growth hormone oversecretion and undersecretion is relevant to practicing rheumatologists.
Localization (oversecretion) of growth hormone
11) Confidence 0.78 Published 2005 Journal Curr Pain Headache Rep Section Abstract Doc Link 16157062 Disease Relevance 0.63 Pain Relevance 0.22
However, there is increasing appreciation that suboptimal growth hormone secretion, leading to a state of adult growth hormone deficiency, may occur in the setting of chronic inflammatory disease, chronic corticosteroid use, and fibromyalgia.
Localization (secretion) of growth hormone associated with corticosteroid, inflammation, disease, growth hormone deficiency and fibrositis
12) Confidence 0.78 Published 2005 Journal Curr Pain Headache Rep Section Abstract Doc Link 16157062 Disease Relevance 0.65 Pain Relevance 0.22
These and other studies suggest that prolonged stimulation of the hypothalamus by clonidine may ameliorate the impairment of growth hormone release seen in some children with constitutional growth delay.
Localization (release) of growth hormone in hypothalamus associated with clonidine
13) Confidence 0.78 Published 1986 Journal J. Pediatr. Section Abstract Doc Link 3095519 Disease Relevance 0 Pain Relevance 0.35
The effect of exposition to novel environment or of morphine administration on the release of prolactin, growth hormone and corticosterone by rats of a strain exhibiting high sensitivity to acoustic epileptogenic stimulus (Wistar-AVN) was compared to that of normally sensitive rats of the Long Evans strain.
Localization (release) of growth hormone associated with sprains and strains and morphine
14) Confidence 0.77 Published 1984 Journal Endocrinol. Exp. Section Abstract Doc Link 6335081 Disease Relevance 0.48 Pain Relevance 0.31
The role of alpha 2-adrenergic receptors (adrenoceptors) in the secretion of growth hormone, prolactin and thyrotropin was studied using highly selective agonists and antagonists of the alpha 2-adrenoceptor.
Localization (secretion) of growth hormone associated with antagonist and agonist
15) Confidence 0.77 Published 1996 Journal Pharmacol. Toxicol. Section Abstract Doc Link 8882345 Disease Relevance 0 Pain Relevance 0.56
Morphine (5 mg/kg)-induced stimulation of growth hormone secretion was antagonized by both naloxone (mu-opioid antagonist) and atipamezole.
Localization (secretion) of growth hormone associated with antagonist, narcan, opioid and morphine
16) Confidence 0.77 Published 1996 Journal Pharmacol. Toxicol. Section Abstract Doc Link 8882345 Disease Relevance 0 Pain Relevance 1.26
Evidently, adrenergic mechanisms are involved in the morphine-induced stimulation of growth hormone secretion, but not in the morphine-induced stimulation of prolactin secretion.
Localization (secretion) of growth hormone associated with morphine
17) Confidence 0.77 Published 1996 Journal Pharmacol. Toxicol. Section Abstract Doc Link 8882345 Disease Relevance 0 Pain Relevance 1.23
The stimulation of alpha 2-adrenoceptor enhances secretion of both growth hormone and prolactin.
Localization (secretion) of growth hormone
18) Confidence 0.77 Published 1996 Journal Pharmacol. Toxicol. Section Abstract Doc Link 8882345 Disease Relevance 0 Pain Relevance 1.32
The interplay between opiates and alpha 2-adrenergic drugs in the acute secretion of growth hormone and prolactin, as well as the possible cross-tolerance between morphine (mu-opioid receptor agonist) and dexmedetomidine (alpha 2-adrenoceptor agonist) in growth hormone secretion were also evaluated.
Localization (secretion) of growth hormone associated with agonist, tolerance, opioid receptor, opiate and morphine
19) Confidence 0.77 Published 1996 Journal Pharmacol. Toxicol. Section Abstract Doc Link 8882345 Disease Relevance 0 Pain Relevance 0.86
The enhanced secretion of both growth hormone and prolactin was antagonized by atipamezole (an alpha 2-adrenoceptor antagonist) but not by prazosin (an alpha 1-adrenoceptor antagonist).
Localization (secretion) of growth hormone associated with antagonist
20) Confidence 0.77 Published 1996 Journal Pharmacol. Toxicol. Section Abstract Doc Link 8882345 Disease Relevance 0 Pain Relevance 1.11

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