INT76706

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Context Info
Confidence 0.22
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.49
Pain Relevance 2.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptger3) signal transducer activity (Ptger3)
Anatomy Link Frequency
uterine 4
CECs 2
Ptger3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 22 99.84 Very High Very High Very High
Dismenorea 2 99.56 Very High Very High Very High
COX-2 inhibitor 2 98.48 Very High Very High Very High
Analgesic 2 83.32 Quite High
metalloproteinase 5 78.88 Quite High
Catecholamine 2 76.16 Quite High
Inflammation 8 75.84 Quite High
Central nervous system 2 54.32 Quite High
Inflammatory response 2 39.44 Quite Low
cOX1 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Dysmenorrhea 2 99.56 Very High Very High Very High
Neurodegenerative Disease 2 85.52 High High
Disease 13 82.00 Quite High
INFLAMMATION 14 75.84 Quite High
Death 2 67.60 Quite High
Toxicity 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Dementia 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We observed that on days 5 and 8 of psp, the L-NMMA (300 microM) treatment did not affect PGE production, but on day 9 of psp, the preincubation with the NOS inhibitor diminished PGE synthesis, suggesting that at this time endogenous NO can upregulate uterine PGE production.
Positive_regulation (upregulate) of Gene_expression (production) of PGE in uterine
1) Confidence 0.22 Published 1998 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 9690710 Disease Relevance 0 Pain Relevance 0.08
In summary, we suggest that in uterine tissue from psp rats, the NO system can alternatively decrease or increase uterine contractions, this last effect by enhancing uterine PGE synthesis.
Positive_regulation (enhancing) of Gene_expression (synthesis) of PGE in uterine associated with dismenorea
2) Confidence 0.22 Published 1998 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 9690710 Disease Relevance 0.10 Pain Relevance 0.10
Thus, it is possible that the combination of LPS and NE might induce the expression or increase the activity of other enzymes involved in PGE2 synthesis, such as phospholipase A2 and/or PGE synthases.
Spec (might) Positive_regulation (increase) of Gene_expression (synthases) of PGE
3) Confidence 0.18 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0.39 Pain Relevance 0.26
In addition, the selective COX-2 inhibitor NS398 (1 microM) was equally as effective as acetaminophen in blocking LPS-induced PGE(2) production.
Positive_regulation (induced) of Gene_expression (production) of PGE associated with paracetamol and cox-2 inhibitor
4) Confidence 0.05 Published 2005 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15618346 Disease Relevance 0 Pain Relevance 1.02
Acetaminophen dose-dependently inhibited both basal and LPS-induced PGE(2) production in CECs with IC(50) values of 15.5 and 6.9 microM, respectively.
Positive_regulation (induced) of Gene_expression (production) of PGE in CECs associated with paracetamol
5) Confidence 0.05 Published 2005 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15618346 Disease Relevance 0 Pain Relevance 0.77

General Comments

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