INT76707

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Context Info
Confidence 0.20
First Reported 1998
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.56
Pain Relevance 3.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptger3) signal transducer activity (Ptger3)
Anatomy Link Frequency
CECs 2
uterine 2
Ptger3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 33 99.92 Very High Very High Very High
cINOD 1 99.84 Very High Very High Very High
adenocard 2 99.00 Very High Very High Very High
COX-2 inhibitor 3 98.74 Very High Very High Very High
Pain 2 98.24 Very High Very High Very High
Inflammation 3 97.48 Very High Very High Very High
Arthritis 8 97.24 Very High Very High Very High
Analgesic 3 84.48 Quite High
Dismenorea 1 77.12 Quite High
Central nervous system 3 72.40 Quite High
Disease Link Frequency Relevance Heat
Necrosis 2 100.00 Very High Very High Very High
Cancer 2 100.00 Very High Very High Very High
INFLAMMATION 4 99.72 Very High Very High Very High
Arthritis 2 99.36 Very High Very High Very High
Autoimmune Disease 10 98.28 Very High Very High Very High
Pain 2 98.24 Very High Very High Very High
Pressure And Volume Under Development 2 98.00 Very High Very High Very High
Experimental Arthritis 8 97.24 Very High Very High Very High
Disease 2 82.48 Quite High
Syndrome 1 65.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We observed that on days 5 and 8 of psp, the L-NMMA (300 microM) treatment did not affect PGE production, but on day 9 of psp, the preincubation with the NOS inhibitor diminished PGE synthesis, suggesting that at this time endogenous NO can upregulate uterine PGE production.
Negative_regulation (diminished) of Gene_expression (synthesis) of PGE in uterine
1) Confidence 0.20 Published 1998 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 9690710 Disease Relevance 0 Pain Relevance 0.08
It also inhibited production of interleukin-1, tumor necrosis factor-alpha, and PGE(2) and increased cyclic adenosine monophosphate levels in rats with AA.
Negative_regulation (inhibited) of Gene_expression (production) of PGE associated with necrosis, adenocard, cancer and arthritis
2) Confidence 0.11 Published 2007 Journal Adv Ther Section Abstract Doc Link 17660179 Disease Relevance 1.69 Pain Relevance 0.73
In an effort to further understand the role of arachidonic acid metabolism and iNOS in the pathogenesis of D-penicillamine-induced autoimmunity we had 3 objectives: (1) to test whether aminoguanidine and misoprostol could reverse D-penicillamine-induced autoimmunity; (2) whether BN rats that had previously developed D-penicillamine-induced autoimmunity could be protected on re-challenge with drug by pretreatment with aminoguanidine and misoprostol and (3) whether non-steroidal anti-inflammatory drugs, which inhibit PGE synthesis, would potentiate D-penicillamine-induced autoimmunity.
Negative_regulation (inhibit) of Gene_expression (synthesis) of PGE associated with inflammation, autoimmune disease and cinod
3) Confidence 0.08 Published 2003 Journal Toxicology Section Abstract Doc Link 12927381 Disease Relevance 0.87 Pain Relevance 0.10
In addition, the selective COX-2 inhibitor NS398 (1 microM) was equally as effective as acetaminophen in blocking LPS-induced PGE(2) production.
Negative_regulation (blocking) of Gene_expression (production) of PGE associated with paracetamol and cox-2 inhibitor
4) Confidence 0.05 Published 2005 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15618346 Disease Relevance 0 Pain Relevance 1.02
In LPS-stimulated isolated cerebral microvessels, acetaminophen also significantly inhibited PGE(2) production.
Negative_regulation (inhibited) of Gene_expression (production) of PGE associated with paracetamol
5) Confidence 0.05 Published 2005 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15618346 Disease Relevance 0 Pain Relevance 1.03
Acetaminophen dose-dependently inhibited both basal and LPS-induced PGE(2) production in CECs with IC(50) values of 15.5 and 6.9 microM, respectively.
Negative_regulation (inhibited) of Gene_expression (production) of PGE in CECs associated with paracetamol
6) Confidence 0.05 Published 2005 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15618346 Disease Relevance 0 Pain Relevance 0.77

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