INT76713

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Context Info
Confidence 0.40
First Reported 1998
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 14.52
Pain Relevance 2.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PECAM1) extracellular space (PECAM1) cell adhesion (PECAM1)
plasma membrane (PECAM1)
Anatomy Link Frequency
granulocytes 4
endothelial cells 4
vasculature 4
vascular endothelium 2
Leukocyte 2
PECAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 91 100.00 Very High Very High Very High
Inflammation 220 99.90 Very High Very High Very High
chemokine 12 97.52 Very High Very High Very High
Central nervous system 1 94.76 High High
fibrosis 104 93.20 High High
Pain 6 93.04 High High
substance P 1 92.24 High High
antinociception 3 84.80 Quite High
Opioid 3 82.00 Quite High
opioid receptor 1 79.28 Quite High
Disease Link Frequency Relevance Heat
Nicotine Addiction 549 100.00 Very High Very High Very High
Adhesions 371 100.00 Very High Very High Very High
INFLAMMATION 254 99.90 Very High Very High Very High
Asthma 82 99.84 Very High Very High Very High
Respiratory Syncytial Virus 62 98.64 Very High Very High Very High
Disease 112 98.52 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 66 98.12 Very High Very High Very High
Increased Venous Pressure Under Development 59 97.88 Very High Very High Very High
Periodontal Disease 33 96.96 Very High Very High Very High
Viral Infection 8 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As much of the pulmonary tissue destruction in COPD is thought to be due to the recruitment and activation of inflammatory cells, several researchers have examined the influence of smoking on adhesion molecule expression and release by the endothelial cells comprising the pulmonary vasculature, and recruited alveolar inflammatory cells.
Spec (examined) Regulation (influence) of Gene_expression (expression) of adhesion molecule in vasculature associated with nicotine addiction, inflammation, chronic obstructive pulmonary disease and adhesions
1) Confidence 0.40 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 2.01 Pain Relevance 0.17
As much of the pulmonary tissue destruction in COPD is thought to be due to the recruitment and activation of inflammatory cells, several researchers have examined the influence of smoking on adhesion molecule expression and release by the endothelial cells comprising the pulmonary vasculature, and recruited alveolar inflammatory cells.
Regulation (influence) of Gene_expression (expression) of adhesion molecule in vasculature associated with nicotine addiction, inflammation, chronic obstructive pulmonary disease and adhesions
2) Confidence 0.40 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 2.01 Pain Relevance 0.17
In summary, there is growing evidence that smoking influences tissue and cellular adhesion molecule expression profiles in several smoking-induced diseases: COPD; vascular diseases; and CIPD.
Regulation (influences) of Gene_expression (expression) of adhesion molecule associated with nicotine addiction, chronic obstructive pulmonary disease, periodontal disease, increased venous pressure under development, disease and adhesions
3) Confidence 0.18 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.99 Pain Relevance 0.07
PTPi IV also has both CD31 and dsDNA above 0.8, but when compared with the morphological results (Fig. 4D), it is observed that the inhibitor had an inhibitory effect on the endothelial cells, despite the high CD31 detection in the ELISA procedure.
Regulation (effect) of Gene_expression (detection) of CD31 in endothelial cells
4) Confidence 0.13 Published 2010 Journal Apmis Section Body Doc Link PMC2806050 Disease Relevance 0 Pain Relevance 0
RESULTS: In vitro studies revealed a variety of mechanisms related to the anti-inflammatory effect, in particular the modulation of cytokine and adhesion molecule expression on activated endothelial cells and leukocytes, and of nitric oxide (NO) production and oxidative burst in activated macrophages and native granulocytes.
Regulation (modulation) of Gene_expression (expression) of adhesion molecule in granulocytes
5) Confidence 0.06 Published 2007 Journal Int. J. Radiat. Biol. Section Body Doc Link 17487675 Disease Relevance 0 Pain Relevance 0
In addition, any major activation of

the granulocytes in particular will be reflected in a change in the expression of adhesion molecules on their surface.

Regulation (change) of Gene_expression (expression) of adhesion in granulocytes associated with adhesions
6) Confidence 0.01 Published 1999 Journal Crit Care Section Body Doc Link PMC29032 Disease Relevance 1.33 Pain Relevance 0.06
DHEA modulated the adhesion molecule expression in endothelial cells and neutrophiles, and most effects were detectable within the physiological concentration.
Regulation (modulated) of Gene_expression (expression) of adhesion molecule in endothelial cells associated with adhesions
7) Confidence 0.01 Published 2007 Journal Crit Care Section Body Doc Link PMC2206506 Disease Relevance 0.94 Pain Relevance 0.06
However, DHEA did not influence the adhesion molecule expression pattern after LPS stimulus.
Neg (not) Regulation (influence) of Gene_expression (expression) of adhesion molecule associated with adhesions
8) Confidence 0.01 Published 2007 Journal Crit Care Section Body Doc Link PMC2206506 Disease Relevance 0.84 Pain Relevance 0.06
Decreased monocytic cell influx could be mediated by an effect of FP on production of monocyte-associated chemotactic factors or decreased adhesion molecule expression on endothelial cells lining the postcapillary venules.
Regulation (effect) of Gene_expression (expression) of adhesion molecule in venules associated with adhesions
9) Confidence 0.01 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 0.19 Pain Relevance 0
Finally, although CD36 has been suggested to play a critical role in the pathogenesis of vaso-occlusion, this study, despite including only a small number of patients, supports the idea that the modulation of expression of a single type of adhesion molecule is insufficient to counteract the pathological process leading to vaso-occlusion in SCD patients.
Regulation (modulation) of Gene_expression (expression) of adhesion molecule associated with sickle cell anemia and adhesions
10) Confidence 0.01 Published 2001 Journal Blood Section Abstract Doc Link 11493440 Disease Relevance 0.33 Pain Relevance 0
CXCL10 is a pleiotropic molecule that elicits potent biological effects, including chemotaxis of activated T and NK cells, modulation of adhesion molecule expression, and inhibition of angiogenesis [97,98].
Regulation (modulation) of Gene_expression (expression) of adhesion molecule in NK cells associated with adhesions
11) Confidence 0.00 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.38 Pain Relevance 0.22
Leukocyte recruitment involves (1) up-regulation of adhesion molecule expression through neurokinin-1 (NK1) receptors on endothelial cells, (2) augmented chemokine production, or (3) chemotaxis through NK1 receptors on leukocytes.
Regulation (regulation) of Gene_expression (expression) of adhesion molecule in Leukocyte associated with chemokine and adhesions
12) Confidence 0.00 Published 2007 Journal Anesthesiology Section Abstract Doc Link 18043070 Disease Relevance 0.48 Pain Relevance 0.94
Most impressively, virtually all alterations in extracellular matrix and adhesion molecule gene expression induced by monocrotaline were fully or partially abrogated by tolafentrine (12 genes given in Figure 10).


Regulation (alterations) of Gene_expression (expression) of adhesion molecule in extracellular matrix associated with adhesions
13) Confidence 0.00 Published 2005 Journal Respir Res Section Body Doc Link PMC1291406 Disease Relevance 0.55 Pain Relevance 0.03
Thus, we show an association of adhesion molecule expression and high cytotoxic activity of pulmonary CD8+ T cells during a respiratory viral infection, parallel to findings in lymphoid organs in LCMV infection [8,11].
Regulation (association) of Gene_expression (expression) of adhesion molecule in respiratory associated with viral infection, infection and adhesions
14) Confidence 0.00 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.49 Pain Relevance 0
These results suggest that sTNFR treatment can suppress the airway inflammation via regulation of Th2 cytokine production and adhesion molecule expression in bronchial asthma.
Regulation (regulation) of Gene_expression (expression) of adhesion molecule associated with asthma, inflammation, adhesions and cytokine
15) Confidence 0.00 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730622 Disease Relevance 1.15 Pain Relevance 0.26
These results suggest that sTNFR treatment can suppress the airway inflammation via regulation of Th2 cytokine production and adhesion molecule expression in bronchial asthma.



Regulation (regulation) of Gene_expression (expression) of adhesion molecule associated with asthma, inflammation, adhesions and cytokine
16) Confidence 0.00 Published 2009 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2730622 Disease Relevance 1.01 Pain Relevance 0.32
Other actions of HU, in particular its effects on vascular endothelium, adhesion molecule expression and cytokine production may also play a role in the final therapeutic outcome.
Regulation (effects) of Gene_expression (expression) of adhesion molecule in vascular endothelium associated with adhesions and cytokine
17) Confidence 0.00 Published 1998 Journal Acta Haematol. Section Abstract Doc Link 9691143 Disease Relevance 0.82 Pain Relevance 0.18

General Comments

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