INT76715

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Context Info
Confidence 0.75
First Reported 1998
Last Reported 2009
Negated 3
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 1.89
Pain Relevance 2.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gria3) plasma membrane (Gria3) protein complex (Gria3)
Anatomy Link Frequency
horn 2
neurons 2
thalamus 2
synapses 2
grey matter 1
Gria3 (Mus musculus)
Pain Link Frequency Relevance Heat
Dorsal horn 182 100.00 Very High Very High Very High
Thalamus 91 99.28 Very High Very High Very High
substance P 15 99.00 Very High Very High Very High
Enkephalin 1 98.36 Very High Very High Very High
cerebral cortex 28 98.12 Very High Very High Very High
Anterior cingulate cortex 82 93.32 High High
Spinal cord 98 90.76 High High
long-term potentiation 80 85.72 High High
Glutamate receptor 38 85.48 High High
imagery 7 83.48 Quite High
Disease Link Frequency Relevance Heat
Absence Epilepsy 105 99.36 Very High Very High Very High
Sprains And Strains 142 85.84 High High
Ataxia 35 85.56 High High
Targeted Disruption 90 80.76 Quite High
Pain 52 70.40 Quite High
Injury 5 68.04 Quite High
Drug Dependence 1 53.80 Quite High
Convulsion 35 46.48 Quite Low
INFLAMMATION 8 44.00 Quite Low
Hypersensitivity 9 5.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gria3 encodes GluR3, the other predominant AMPA receptor expressed in the thalamocortical network.
Gene_expression (expressed) of GluR3
1) Confidence 0.75 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405903 Disease Relevance 0.10 Pain Relevance 0
GluR4, in particular, is the predominant AMPA receptor expressed in the thalamic reticular nucleus, where it is expressed 3- to 4-fold higher at corticothalamic synapses than at other reticular and intrathalamic sites, making the thalamic reticular nucleus a potentially critical site of action; GluR3 is also expressed but at lower levels (21,36).
Gene_expression (expressed) of GluR3 in synapses
2) Confidence 0.75 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405903 Disease Relevance 0.07 Pain Relevance 0.04
Although both Gria3 and Gria4 expressed in the reticular thalamus, it has been shown previously that Gria4 encodes the predominant subunit in this critical region which, together with the cortex and thalamus form the thalamocortical circuit (4).
Gene_expression (expressed) of Gria3 in thalamus associated with thalamus
3) Confidence 0.75 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405903 Disease Relevance 0.38 Pain Relevance 0.18
Mice that lack GluR3 show no SWD (Fig. 1, Gria3 ko).
Neg (lack) Gene_expression (lack) of GluR3
4) Confidence 0.65 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405903 Disease Relevance 0.09 Pain Relevance 0
The Gria3tm1Dgen mutation was genotyped in standard PCR conditions as above in a 3-primer assays using oligonucleotides designed by Deltagen 39637: 5?
Gene_expression (mutation) of Gria3tm1Dgen
5) Confidence 0.65 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405903 Disease Relevance 0.28 Pain Relevance 0
We did not observe any gross difference in GluR3 expression in either spwk1 or in Gria4 null mice, in the cerebral cortex or in microdissected thalamus/reticular thalamus (Supplementary Material, Fig.
Gene_expression (expression) of GluR3 in thalamus associated with thalamus and cerebral cortex
6) Confidence 0.58 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405903 Disease Relevance 0.21 Pain Relevance 0.19
The other two subunits of AMPA receptor, GluA3 and GluA4 express at relative lower levels [21,22].
Gene_expression (express) of GluA3
7) Confidence 0.47 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0.31 Pain Relevance 0.81
Although both Gria3 and Gria4 expressed in the reticular thalamus, it has been shown previously that Gria4 encodes the predominant subunit in this critical region which, together with the cortex and thalamus form the thalamocortical circuit (4).
Gene_expression (expressed) of Gria3 in cortex associated with thalamus
8) Confidence 0.25 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405903 Disease Relevance 0.38 Pain Relevance 0.18
From each section, 400 pan-AMPAr-labelled puncta were selected (100 each from laminae I, IIo, IIi and III) and these were then examined to determine whether they were immunoreactive with the GluR1, GluR3 or GluR4 antibodies.
Gene_expression (antibodies) of GluR3
9) Confidence 0.22 Published 2008 Journal Mol Pain Section Body Doc Link PMC2248168 Disease Relevance 0 Pain Relevance 0.08
Approximately 10% of the pan-AMPAr-positive puncta in laminae I–III in these sections were not immunostained with either GluR1 or GluR3 antibodies (Table 2).
Gene_expression (antibodies) of GluR3
10) Confidence 0.22 Published 2008 Journal Mol Pain Section Body Doc Link PMC2248168 Disease Relevance 0 Pain Relevance 0.03
GluR3-immunoreactive puncta were also present throughout the grey matter.
Gene_expression (present) of GluR3 in grey matter
11) Confidence 0.22 Published 2008 Journal Mol Pain Section Body Doc Link PMC2248168 Disease Relevance 0 Pain Relevance 0.19
Staining for GluR1, GluR2 and GluR3 was absent in sections from mice in which these subunits had been knocked out, while the punctate staining for PSD-95 was absent in mice with a mutation that prevents accumulation of PSD-95 at synapses.


Neg (absent) Gene_expression (absent) of GluR3 in synapses
12) Confidence 0.19 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2248168 Disease Relevance 0.06 Pain Relevance 0.07
In contrast, the long form of the GluR4 subunit has a much more restricted distribution in the superficial dorsal horn, and appears to be associated with specific types of neuron, many of which also express GluR2 and GluR3, but not GluR1.
Neg (not) Gene_expression (express) of GluR3 in neuron associated with dorsal horn
13) Confidence 0.19 Published 2008 Journal Mol Pain Section Body Doc Link PMC2248168 Disease Relevance 0 Pain Relevance 0.26
GluR3 and 4 were found at relatively high density in deep dorsal horn and ventral horn, but were also present in some synapses in the superficial laminae.
Gene_expression (found) of GluR3 in horn associated with dorsal horn
14) Confidence 0.19 Published 2008 Journal Mol Pain Section Body Doc Link PMC2248168 Disease Relevance 0 Pain Relevance 0.26
GluR3 and 4 were found at relatively high density in deep dorsal horn and ventral horn, but were also present in some synapses in the superficial laminae.
Gene_expression (present) of GluR3 in horn associated with dorsal horn
15) Confidence 0.19 Published 2008 Journal Mol Pain Section Body Doc Link PMC2248168 Disease Relevance 0 Pain Relevance 0.27
However, GluR3 mRNA was preferentially expressed by neurons coexpressing substance P and enkephalin and GluR4 mRNA was not detected in identified medium spiny neurons.
Gene_expression (expressed) of GluR3 mRNA in neurons associated with enkephalin and substance p
16) Confidence 0.01 Published 1998 Journal Dev. Neurosci. Section Abstract Doc Link 9691198 Disease Relevance 0 Pain Relevance 0.23

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