INT7674

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Context Info
Confidence 0.30
First Reported 1984
Last Reported 2010
Negated 5
Speculated 2
Reported most in Abstract
Documents 42
Total Number 44
Disease Relevance 11.41
Pain Relevance 14.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ENG) cell motility (ENG) cell adhesion (ENG)
nucleolus (ENG) nucleus (ENG) cytoplasm (ENG)
Anatomy Link Frequency
plasma 4
pituitary 3
CSF 2
hypothalamus 2
brain 1
ENG (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 97 100.00 Very High Very High Very High
Enkephalin 41 100.00 Very High Very High Very High
opioid receptor 31 100.00 Very High Very High Very High
Neuropeptide 28 100.00 Very High Very High Very High
Morphine 25 100.00 Very High Very High Very High
Endogenous opioid 24 100.00 Very High Very High Very High
Somatostatin 20 100.00 Very High Very High Very High
Pain threshold 9 99.92 Very High Very High Very High
dexamethasone 9 99.84 Very High Very High Very High
Dynorphin 4 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 85 100.00 Very High Very High Very High
Pain 67 99.92 Very High Very High Very High
Hypothermia 6 99.70 Very High Very High Very High
Urological Neuroanatomy 18 99.52 Very High Very High Very High
Alcohol Addiction 4 99.28 Very High Very High Very High
Hyperalgesia 75 98.60 Very High Very High Very High
Injury 12 98.60 Very High Very High Very High
Toxicity 11 98.00 Very High Very High Very High
Head Trauma 26 97.84 Very High Very High Very High
Arthritis 32 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was also congruence regarding end-of-life care preferences, specifically the importance of quality care, treatment with dignity and respect, and avoiding unnecessary life-sustaining treatment.
Regulation (regarding) of end-of-life
1) Confidence 0.30 Published 2009-2010 Journal Omega (Westport) Section Abstract Doc Link 20361726 Disease Relevance 0.17 Pain Relevance 0.14
In this study, we evaluated the influence of morphine and the stress responsive opioid peptide beta-endorphin (beta-END) on O-2 and H2O2 production by cultured human peripheral blood mononuclear cells.
Regulation (influence) of beta-END in blood associated with stress, opioid and morphine
2) Confidence 0.22 Published 1987 Journal J. Immunol. Section Abstract Doc Link 3035015 Disease Relevance 0.29 Pain Relevance 0.63
In the last two groups, beta-End levels were measured in plasma and CSF.
Regulation (measured) of beta-End in plasma
3) Confidence 0.22 Published 1988 Journal Rev. Esp. Fisiol. Section Abstract Doc Link 2972025 Disease Relevance 0.28 Pain Relevance 0.35
Conversely, genistein can activate Smad1 in a manner that is dependent on ALK-2 kinase activity, but that is independent of endoglin [159].
Neg (independent) Regulation (independent) of endoglin
4) Confidence 0.17 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 0.54 Pain Relevance 0
RESULTS: At baseline, beta-END response was similar in patients and controls.
Regulation (response) of beta-END
5) Confidence 0.16 Published 2008 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Body Doc Link 18725263 Disease Relevance 0 Pain Relevance 0
METHODS: The beta-END response to the 5-HT1A receptor agonist, buspirone (30 mg), was measured in 30 patients with major depression and in 30 age- and sex-matched healthy controls before and after an 8-week treatment with citalopram.
Regulation (response) of beta-END
6) Confidence 0.16 Published 2008 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Body Doc Link 18725263 Disease Relevance 0 Pain Relevance 0
Changes in surface markers (CD105, CD44, SSEA, PDGFR alpha) after the differentiation treatments were also analyzed.
Regulation (Changes) of CD105
7) Confidence 0.16 Published 2009 Journal Stem Cells Dev. Section Abstract Doc Link 18454697 Disease Relevance 0.09 Pain Relevance 0.09
Unexpectedly, the expression of CD34 was present in the majority of cultures, albeit that the signal was not as strong as for the markers CD73, CD105, and CD90.
Neg (not) Regulation (strong) of CD105
8) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875643 Disease Relevance 0.35 Pain Relevance 0.17
However, toxicants often operate to produce multisite toxicity via multiple end points and likely multiple mechanisms, meaning data are needed to determine which end point is the most toxicologically sensitive.
Regulation (sensitive) of end associated with toxicity
9) Confidence 0.14 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852676 Disease Relevance 0.16 Pain Relevance 0
The effect of beta-endorphin (beta-END) and the role of the adrenal and thyroid glands on body temperature were examined in male rats in a controlled environment room at 24.5 +/- 0.1 degrees C.
Regulation (role) of beta-END in body
10) Confidence 0.13 Published 1985 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 3156382 Disease Relevance 0.06 Pain Relevance 0.10
Symptom control at the end of life
Regulation (control) of end
11) Confidence 0.10 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2528206 Disease Relevance 0.41 Pain Relevance 0.09
Although there was some variability in the control END levels among experimental sets (Fig. 4) this does not seem to predict the efficacy of POMC-MIDGE-NLS in END production.
Regulation (control) of END
12) Confidence 0.07 Published 2009 Journal Mol Pain Section Body Doc Link PMC2797781 Disease Relevance 0.57 Pain Relevance 0.26
The effects of beta-endorphin (beta-END) on cardiovascular and behavioral dynamics in conscious rats.
Regulation (effects) of beta-END
13) Confidence 0.07 Published 2002 Journal Brain Res. Bull. Section Title Doc Link 12372545 Disease Relevance 0 Pain Relevance 0.23
For example, even though the control END levels in Fig. 4A and Fig. 4B were comparable, the END levels after different doses of POMC-MIDGE-NLS varied between the two graphs.
Regulation (control) of END
14) Confidence 0.04 Published 2009 Journal Mol Pain Section Body Doc Link PMC2797781 Disease Relevance 0.50 Pain Relevance 0.32
Thus, despite differences in the control END levels in Fig. 4A, B and 4C, the basal PPT (after CFA but before control vector injection) were comparable among these three graphs.
Regulation (control) of END
15) Confidence 0.04 Published 2009 Journal Mol Pain Section Body Doc Link PMC2797781 Disease Relevance 0.42 Pain Relevance 0.42
The central and peripheral levels of neurosteroid allopregnanolone and the opioid peptide beta-endorphin (beta-END) are regulated by estrogens.
Regulation (regulated) of beta-END associated with opioid
16) Confidence 0.03 Published 2006 Journal Neuroendocrinology Section Abstract Doc Link 16931878 Disease Relevance 0 Pain Relevance 0.15
The purpose of this study was to determine the plasma levels of beta-endorphin (beta-END) and ACTH in the perioperative period, define correlations of hormonal plasma levels with clinical parameters and establish the effect of droperidol premedication on hormonal levels and clinical parameters. 2.
Regulation (effect) of beta-END in plasma
17) Confidence 0.02 Published 1989 Journal Gen. Pharmacol. Section Abstract Doc Link 2546852 Disease Relevance 0.05 Pain Relevance 0.08
Hypothermia per se had no effect on ACTH, beta-END, and HIS concentrations.
Neg (no) Regulation (effect) of beta-END associated with hypothermia
18) Confidence 0.02 Published 1989 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 2475284 Disease Relevance 0.26 Pain Relevance 0.84
To follow the neurohormonal background of the stress-induced disturbances in LH release and in the course of oestrous cycle in sheep the concentrations of beta-endorphin (beta-END) in the infundibular and paraventricular nuclei as well as in the pituitary gland under physiological and stress conditions were determined, while in rats the metabolism of brain serotonin was investigated.
Regulation (concentrations) of beta-END in brain associated with stress and serotonin
19) Confidence 0.02 Published 1989 Journal Acta Physiol Pol Section Abstract Doc Link 2532447 Disease Relevance 0.54 Pain Relevance 0.08
The effect of the endogenous opioid peptides, methionine-enkephalin (Met-ENK), beta-endorphin (beta-END) and dynorphin-(1-17) (DYN) on the aversive behavior produced by intrathecal (i.t.) administration of substance P (SP) was studied in mice.
Regulation (effect) of beta-END associated with dynorphin, endogenous opioid, enkephalin, substance p and intrathecal
20) Confidence 0.02 Published 1988 Journal Brain Res. Section Abstract Doc Link 2451988 Disease Relevance 0 Pain Relevance 0.90

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