INT76743

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Context Info
Confidence 0.76
First Reported 1998
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 55
Total Number 60
Disease Relevance 13.53
Pain Relevance 24.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc6a4) endosome (Slc6a4) plasma membrane (Slc6a4)
Anatomy Link Frequency
B-cell 4
brain 3
adult heart 3
artery smooth muscle 2
lung 2
Slc6a4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 486 100.00 Very High Very High Very High
positron emission tomography 6 100.00 Very High Very High Very High
Cannabinoid 6 100.00 Very High Very High Very High
Opioid 4 100.00 Very High Very High Very High
Triptan 1 100.00 Very High Very High Very High
imagery 8 99.98 Very High Very High Very High
antidepressant 385 99.96 Very High Very High Very High
Neuropeptide 8 99.78 Very High Very High Very High
midbrain 10 99.68 Very High Very High Very High
Raphe 25 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypertension 41 100.00 Very High Very High Very High
Manic Depressive Disorder 11 99.96 Very High Very High Very High
Shock 15 99.78 Very High Very High Very High
Hyperplasia 7 99.76 Very High Very High Very High
Urological Neuroanatomy 42 99.52 Very High Very High Very High
Pulmonary Hypertension 256 99.20 Very High Very High Very High
Hypoxia 10 98.64 Very High Very High Very High
Chronic Lymphoid Leukemia 4 98.48 Very High Very High Very High
Mantle-cell Lymphoma 4 97.24 Very High Very High Very High
Pain 9 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serotonin transporter messenger RNA was widely expressed beginning prior to organogenesis and throughout the second half of gestation.
Gene_expression (expressed) of Serotonin transporter messenger RNA associated with serotonin
1) Confidence 0.76 Published 1999 Journal Neuroscience Section Abstract Doc Link 10051233 Disease Relevance 0 Pain Relevance 0.52
Strikingly, serotonin transporter messenger RNA was detected in neural crest cells, some of which respond to serotonin in vitro, and neural crest-derived tissues, such as autonomic ganglia, tooth primordia, adrenal medulla, chondrocytes and neuroepithelial cells, in the skin, heart, intestine and lung.
Gene_expression (detected) of serotonin transporter messenger RNA in adrenal medulla associated with medulla and serotonin
2) Confidence 0.76 Published 1999 Journal Neuroscience Section Abstract Doc Link 10051233 Disease Relevance 0 Pain Relevance 0.55
In situ hybridization histochemistry was used to delineate serotonin transporter messenger RNA expression during rat embryonic development.
Gene_expression (expression) of serotonin transporter messenger RNA associated with serotonin
3) Confidence 0.76 Published 1999 Journal Neuroscience Section Abstract Doc Link 10051233 Disease Relevance 0 Pain Relevance 0.51
The expression of serotonin transporter messenger RNA throughout the sensory pathways from central nervous system relay stations [Hansson S.
Gene_expression (expression) of serotonin transporter messenger RNA in central nervous system associated with central nervous system and serotonin
4) Confidence 0.76 Published 1999 Journal Neuroscience Section Abstract Doc Link 10051233 Disease Relevance 0 Pain Relevance 0.65
As a target for drugs, such as cocaine, amphetamine derivatives and antidepressants, expression of serotonin transporter during development may reflect critical periods of vulnerability for fetal drug exposure.
Gene_expression (expression) of serotonin transporter associated with antidepressant, serotonin and cocaine
5) Confidence 0.76 Published 1999 Journal Neuroscience Section Abstract Doc Link 10051233 Disease Relevance 0 Pain Relevance 0.58
Changes in serotonin, serotonin transporter expression and serotonin denervation supersensitivity: involvement in chronic central pain after spinal hemisection in the rat.
Gene_expression (expression) of serotonin transporter in spinal associated with pain, central pain and serotonin
6) Confidence 0.67 Published 2002 Journal Exp. Neurol. Section Title Doc Link 12061865 Disease Relevance 0.81 Pain Relevance 1.01
Serotonin transporter messenger RNA was detected in several neural crest cell lineages and may be useful as an early marker for the sensory lineage in particular.
Gene_expression (detected) of Serotonin transporter messenger RNA in neural crest cell associated with serotonin
7) Confidence 0.67 Published 1999 Journal Neuroscience Section Abstract Doc Link 10051233 Disease Relevance 0 Pain Relevance 0.59
The widespread distribution of serotonin transporter messenger RNA during ontogeny suggests a previously unappreciated role of serotonin in diverse physiological systems during embryonic development.
Gene_expression (distribution) of serotonin transporter messenger RNA associated with serotonin
8) Confidence 0.66 Published 1999 Journal Neuroscience Section Abstract Doc Link 10051233 Disease Relevance 0 Pain Relevance 0.51
BACKGROUND: Progression of pulmonary hypertension (PH) is associated with increased lung expression of the serotonin transporter (5-HTT), which leads to hyperplasia of the pulmonary artery smooth muscle cells (PA-SMCs).
Gene_expression (expression) of serotonin transporter in artery smooth muscle associated with hypertension, serotonin and hyperplasia
9) Confidence 0.65 Published 2005 Journal Circulation Section Abstract Doc Link 15927991 Disease Relevance 0.54 Pain Relevance 0.21
Reverse transcriptase-PCR demonstrated that astrocytes in culture expressed messenger RNA for the cloned serotonin transporter protein which has been characterised as the neuronal serotonin transporter.
Gene_expression (expressed) of serotonin transporter protein in astrocytes associated with serotonin
10) Confidence 0.61 Published 1998 Journal Neurochem. Int. Section Abstract Doc Link 9694037 Disease Relevance 0 Pain Relevance 0.41
If the early detection of serotonin transporter messenger RNA in skin and gastrointestinal and airway epithelia correlates with protein activity, it may permit establishment of a serotonin concentration gradient across epithelia, either from serotonin in the amniotic fluid or from neuronal enteric serotonin, as a developmental cue.
Gene_expression (detection) of serotonin transporter messenger RNA in neuronal associated with serotonin
11) Confidence 0.59 Published 1999 Journal Neuroscience Section Abstract Doc Link 10051233 Disease Relevance 0 Pain Relevance 0.64
Serotonin transporter messenger RNA expression in neural crest-derived structures and sensory pathways of the developing rat embryo.
Gene_expression (expression) of Serotonin transporter messenger RNA in neural crest associated with serotonin
12) Confidence 0.59 Published 1999 Journal Neuroscience Section Title Doc Link 10051233 Disease Relevance 0 Pain Relevance 0.48
Within the peripheral sensory pathways, two major cells types were serotonin transporter messenger RNA-positive: (i) sensory ganglionic neurons and (ii) neuroepithelial cells which serve as targets for the outgrowing sensory neurons.
Gene_expression (messenger) of serotonin transporter messenger RNA in sensory neurons associated with serotonin
13) Confidence 0.58 Published 1999 Journal Neuroscience Section Abstract Doc Link 10051233 Disease Relevance 0 Pain Relevance 0.61
BACKGROUND: Progression of pulmonary hypertension (PH) is associated with increased lung expression of the serotonin transporter (5-HTT), which leads to hyperplasia of the pulmonary artery smooth muscle cells (PA-SMCs).
Gene_expression (expression) of 5-HTT in artery smooth muscle associated with hypertension, serotonin and hyperplasia
14) Confidence 0.57 Published 2005 Journal Circulation Section Abstract Doc Link 15927991 Disease Relevance 0.54 Pain Relevance 0.21
Functional expression of the serotonin transporter in immortalized rat brain microvessel endothelial cells.
Gene_expression (expression) of serotonin transporter in brain associated with neuropeptide and serotonin
15) Confidence 0.57 Published 2000 Journal J. Neurochem. Section Title Doc Link 10693957 Disease Relevance 0 Pain Relevance 0.24
Although the expression profile of 5-HTT in late fetal and neonatal heart seems to be independent of the reference gene used, the estimated 5-HTT expression in the adult heart differs significantly with the choice of reference gene (Figure 3B).
Gene_expression (expression) of 5-HTT in adult heart
16) Confidence 0.55 Published 2010 Journal BMC Mol Biol Section Body Doc Link PMC2907514 Disease Relevance 0.15 Pain Relevance 0.13
Although the expression profile of 5-HTT in late fetal and neonatal heart seems to be independent of the reference gene used, the estimated 5-HTT expression in the adult heart differs significantly with the choice of reference gene (Figure 3B).
Gene_expression (expression) of 5-HTT in adult heart
17) Confidence 0.55 Published 2010 Journal BMC Mol Biol Section Body Doc Link PMC2907514 Disease Relevance 0.21 Pain Relevance 0.12
To explore the significance of normalization to different reference genes we analyzed the expression of the serotonin 5-HT transporter (5-HTT) during fetal and neonatal development as well as in adult heart.
Spec (analyzed) Gene_expression (expression) of 5-HTT in adult heart associated with serotonin
18) Confidence 0.55 Published 2010 Journal BMC Mol Biol Section Body Doc Link PMC2907514 Disease Relevance 0.15 Pain Relevance 0.13
In tooth development, serotonin appears to stimulate odontogenesis by interacting with different serotonin receptors13 expressed in the epithelium and dental mesenchyme during odontogenesis9 and through sites of 5-HT uptake present in the tooth germ during development.14 The administration of fluoxetine in pregnant rats can alter the levels of available serotonin, making it possible to study its influence on tooth development, which, in turn, results from important epithelial-mesenchymal interactions3.
Gene_expression (expressed) of serotonin receptors13 in tooth germ associated with serotonin and fluoxetine
19) Confidence 0.47 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2815284 Disease Relevance 0 Pain Relevance 0.62
In addition, the effect of EA on 5-HT(4a) receptor and serotonin transporter (SERT) expression in the colon mucosa was analyzed semi-quantitatively through immunohistochemistry and 5-HT concentration in the colon tissue was observed through spectro-photo-fluorimeter detection, respectively.
Gene_expression (expression) of serotonin transporter in colon associated with serotonin
20) Confidence 0.46 Published 2006 Journal Brain Res. Section Abstract Doc Link 16650387 Disease Relevance 0.89 Pain Relevance 0.69

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