INT7675

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Context Info
Confidence 0.77
First Reported 1984
Last Reported 2010
Negated 12
Speculated 5
Reported most in Abstract
Documents 146
Total Number 151
Disease Relevance 45.35
Pain Relevance 34.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ENG) cell motility (ENG) cell adhesion (ENG)
nucleolus (ENG) nucleus (ENG) cytoplasm (ENG)
Anatomy Link Frequency
plasma 7
immune cells 6
stem cells 6
endothelial cells 5
pituitary 4
ENG (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 636 100.00 Very High Very High Very High
Enkephalin 159 100.00 Very High Very High Very High
Endogenous opioid 138 100.00 Very High Very High Very High
withdrawal 37 100.00 Very High Very High Very High
opiate 20 100.00 Very High Very High Very High
opioid receptor 292 99.98 Very High Very High Very High
antinociception 144 99.92 Very High Very High Very High
Pain threshold 12 99.88 Very High Very High Very High
midbrain 11 99.86 Very High Very High Very High
IPN 216 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 365 100.00 Very High Very High Very High
Reprotox - General 1 63 100.00 Very High Very High Very High
Fibromyalgia 18 100.00 Very High Very High Very High
Pain 340 99.88 Very High Very High Very High
Urological Neuroanatomy 27 99.86 Very High Very High Very High
Inflammatory Pain 216 99.84 Very High Very High Very High
Rheumatoid Arthritis 205 99.84 Very High Very High Very High
Depression 53 99.84 Very High Very High Very High
Hypertension 65 99.80 Very High Very High Very High
Hyperalgesia 530 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In adenomyosis and ovarian endometriosis, the expression pattern was different - endoglin was expressed in all microvessels, with an even stronger expression in the myometrial compartment.
Gene_expression (expressed) of endoglin associated with endometriosis and dismenorea
1) Confidence 0.77 Published 2005 Journal Reprod Biol Section Abstract Doc Link 15821778 Disease Relevance 0.83 Pain Relevance 0.39
These data show that the expression of endoglin and S100A13 corresponds to the activation of the endothelial cells in the process of endometriotic angiogenesis, suggesting a beneficial role for these two molecules as markers for actively progressing endometriotic process.
Gene_expression (expression) of endoglin in endothelial cells associated with endometriosis
2) Confidence 0.77 Published 2005 Journal Reprod Biol Section Abstract Doc Link 15821778 Disease Relevance 0.93 Pain Relevance 0.36
Endothelial cell purity was 96–98% as assessed by performing flow cytometry for PECAM-1 (clone MEC 13.3, Pharmingen), Endoglin (Pharmingen) and ICAM-2 expression.
Gene_expression (expression) of Endoglin in Endothelial cell
3) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.07 Pain Relevance 0
The presence of beta-endorphin (beta-end) was immunohistologically identified in synovial tissue samples biopsied from patients with rheumatoid arthritis (RA) and osteoarthritis (OA).
Gene_expression (presence) of end associated with rheumatoid arthritis and osteoarthritis
4) Confidence 0.75 Published 1992 Journal Arerugi Section Abstract Doc Link 1444837 Disease Relevance 0.66 Pain Relevance 0.40
The aim of the present study was to evaluate the expression of the neo-angiogenic marker endoglin and its localization in tissues of normal and endometriotic patients as well as to compare it with one new angiogenic marker candidate - S100A13.
Gene_expression (expression) of endoglin associated with endometriosis
5) Confidence 0.67 Published 2005 Journal Reprod Biol Section Abstract Doc Link 15821778 Disease Relevance 0.35 Pain Relevance 0.13
Human recombinant S100A13 and endoglin 35mer synthetic peptide of the intracellular domain were used for the production of rabbit polyclonal antisera.
Gene_expression (synthetic) of endoglin
6) Confidence 0.67 Published 2005 Journal Reprod Biol Section Abstract Doc Link 15821778 Disease Relevance 0.51 Pain Relevance 0.24
The bone marrow mesenchymal stem cells were identified by FACS on the cell markers of CD105 (using FITC-labeled anti-CD105 antibody, 1?
Gene_expression (antibody) of CD105 in stem cells
7) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852399 Disease Relevance 0.06 Pain Relevance 0
The bone marrow mesenchymal stem cells were identified by FACS on the cell markers of CD105 (using FITC-labeled anti-CD105 antibody, 1?
Gene_expression (antibody) of CD105 in stem cells
8) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852399 Disease Relevance 0.06 Pain Relevance 0
These results indicate that: 1. secretion of beta-END-LI varies during different phases of the estrous cycle, 2. acute stress is a potent activator for beta-END-LI secretion, 3. no apparent increase of beta-END-LI in the blood plasma of ewes subjected to prolonged stress concomitant with accumulation of this material in pituitary (Polkowska and Przekop, 1988) supports the idea, that prolonged stress augments the synthesis of beta-END-LI but not its release.
Gene_expression (synthesis) of END in plasma associated with stress
9) Confidence 0.65 Published 1990 Journal Exp. Clin. Endocrinol. Section Abstract Doc Link 2245820 Disease Relevance 0.43 Pain Relevance 0
In the case of the opioid/orphanin family of genes, duplication events have proceeded along two paths: (a) an apparent duplication of function as seen in the analgesic activity of Proenkephalin and Prodynorphin end-products; and (b) divergence of function as seen in the nociceptic activity of Proorphanin end-products or the melanocortin (color change and chronic stress regulation) activity of Proopiomelanocortin end-products.
Gene_expression (end-products) of end associated with stress, nociception, analgesic, orphanin and opioid
10) Confidence 0.65 Published 1999 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 10082620 Disease Relevance 0.20 Pain Relevance 0.51
Plasma and CSF levels of beta-Endorphin (beta-End) were measured by radioimmunoassay in three groups of human subjects.
Gene_expression (levels) of beta-End in Plasma
11) Confidence 0.62 Published 1988 Journal Rev. Esp. Fisiol. Section Abstract Doc Link 2972025 Disease Relevance 0.22 Pain Relevance 0.22
In adenomyosis and ovarian endometriosis, the expression pattern was different - endoglin was expressed in all microvessels, with an even stronger expression in the myometrial compartment.
Gene_expression (expression) of endoglin associated with endometriosis and dismenorea
12) Confidence 0.60 Published 2005 Journal Reprod Biol Section Abstract Doc Link 15821778 Disease Relevance 0.84 Pain Relevance 0.40
Placental sFlt-1 and sEng production was examined using ELISA. 4.
Spec (examined) Gene_expression (production) of sEng
13) Confidence 0.52 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 19215236 Disease Relevance 0.52 Pain Relevance 0.08
With the exception of frusemide, none of the antihypertensive drugs tested had any effect on sFlt-1 and sEng production from placental explants of normal pregnancy and women with pre-eclampsia.
Gene_expression (production) of sEng associated with eclampsia
14) Confidence 0.52 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 19215236 Disease Relevance 0.41 Pain Relevance 0.06
In conclusion, placental sFlt-1 and sEng production was higher in pre-eclampsia and antihypertensive drugs had no effect on placental production of sFlt-1 and sEng in vitro.
Gene_expression (production) of sEng associated with eclampsia
15) Confidence 0.52 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 19215236 Disease Relevance 0.49 Pain Relevance 0.05
Flow cytometry analysis revealed that the adherent fibroblast-like cells were consistently positive for CD29, CD44, CD105, and CD166, and were negative for CD14, CD34, and CD45.
Gene_expression (positive) of CD105 in fibroblast
16) Confidence 0.50 Published 2007 Journal J. Cell. Physiol. Section Abstract Doc Link 17171634 Disease Relevance 0.61 Pain Relevance 0.07
In contrast, patients with acute pain showed significantly increased levels of beta-End in plasma.
Gene_expression (levels) of beta-End in plasma associated with acute pain
17) Confidence 0.48 Published 1988 Journal Rev. Esp. Fisiol. Section Abstract Doc Link 2972025 Disease Relevance 0.27 Pain Relevance 0.36
CSF levels of beta-End did not show significant differences among the groups.
Gene_expression (levels) of beta-End
18) Confidence 0.48 Published 1988 Journal Rev. Esp. Fisiol. Section Abstract Doc Link 2972025 Disease Relevance 0.27 Pain Relevance 0.36
Whereas there was no association between plasma levels of EPI and i beta END in the EPI group (r = 0.119; P = NS), EPI and i beta END levels were strongly related in the no EPI group (r = 0.82; P less than 0.001).
Gene_expression (levels) of END in EPI
19) Confidence 0.46 Published 1989 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2527244 Disease Relevance 0.31 Pain Relevance 0.07
Increasing frusemide concentrations were correlated with increased sEng production in normal pregnancy (P < 0.005). 5.
Gene_expression (production) of sEng
20) Confidence 0.45 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 19215236 Disease Relevance 0.40 Pain Relevance 0.06

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