INT76751

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Context Info
Confidence 0.13
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.16
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (F13A1) transferase activity, transferring acyl groups (F13A1) cytoplasm (F13A1)
Anatomy Link Frequency
blood 2
PGE1 2
F13A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 3 95.96 Very High Very High Very High
Arthritis 1 93.76 High High
cytokine 6 88.88 High High
cINOD 4 88.72 High High
Inflammation 28 88.48 High High
methotrexate 6 85.28 High High
Restless leg syndrome 2 75.00 Quite High
agonist 43 74.72 Quite High
Angina 1 70.96 Quite High
cva 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 175 100.00 Very High Very High Very High
Peripheral Arterial Disease 4 99.10 Very High Very High Very High
Thrombocytopenia 27 98.44 Very High Very High Very High
Depression 3 95.96 Very High Very High Very High
Arthritis 1 93.76 High High
Splenomegaly 2 93.32 High High
Fever 3 92.76 High High
Adhesions 9 92.56 High High
Hemangioma 28 92.24 High High
Leukemia 12 91.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite the blood counts becoming normal after TAE, fibrin degradation products (FDP) and D-dimer decreased after the surgical removal of the tumor.


Negative_regulation (decreased) of Protein_catabolism (degradation) of fibrin in blood associated with cancer
1) Confidence 0.13 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2936318 Disease Relevance 1.00 Pain Relevance 0
Impaired fibrin degradation, due to high circulating levels of plasminogen activator inhibitor type-1, further enhances intravascular fibrin deposition (Figure 4).
Negative_regulation (Impaired) of Protein_catabolism (degradation) of fibrin
2) Confidence 0.05 Published 2006 Journal Crit Care Section Body Doc Link PMC1750988 Disease Relevance 0.81 Pain Relevance 0.17
Impaired fibrin degradation, due to high circulating levels of PAI-1, contributes to enhanced intravascular fibrin deposition [1].
Negative_regulation (Impaired) of Protein_catabolism (degradation) of fibrin
3) Confidence 0.04 Published 2006 Journal Thromb J Section Body Doc Link PMC1533804 Disease Relevance 0.82 Pain Relevance 0.03
In summary, infusion therapy with PGE1 in patients with PAOD reduces thrombin formation and results in a decrease of fibrin degradation.
Negative_regulation (decrease) of Protein_catabolism (degradation) of fibrin in PGE1 associated with peripheral arterial disease
4) Confidence 0.01 Published 2000 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 11090253 Disease Relevance 0.31 Pain Relevance 0.13
ligands upregulate expression and release of PAI-1 from ECs [193], which would inhibit degradation of tumor-associated fibrin leading to EC migration, proliferation, and angiogenesis [231].
Negative_regulation (inhibit) of Protein_catabolism (degradation) of fibrin associated with cancer
5) Confidence 0.01 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 1.07 Pain Relevance 0.04
The patient had depressed antithrombin III activity and abnormally high concentrations of both fibrin degradation products and thrombin-antithrombin complexes.
Negative_regulation (depressed) of Protein_catabolism (degradation) of fibrin
6) Confidence 0.01 Published 1998 Journal Clin. Rheumatol. Section Abstract Doc Link 9694066 Disease Relevance 0.76 Pain Relevance 0.35
CPU removes C-terminal lysine residues that act as plasminogen binding sites from partially degraded fibrin, thereby down-regulating plasminogen activation and fibrinolysis.
Negative_regulation (down-regulating) of Protein_catabolism (degraded) of fibrin
7) Confidence 0.01 Published 2000 Journal Thromb. Haemost. Section Abstract Doc Link 11019956 Disease Relevance 0.40 Pain Relevance 0.07

General Comments

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