INT76752

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Context Info
Confidence 0.42
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.20
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TOP2B) nucleoplasm (TOP2B) nucleolus (TOP2B)
chromosome (TOP2B) nucleus (TOP2B) enzyme binding (TOP2B)
Anatomy Link Frequency
groove 1
cleavage 1
TOP2B (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 2 81.32 Quite High
withdrawal 1 69.56 Quite High
Inflammation 6 51.84 Quite High
cINOD 10 5.00 Very Low Very Low Very Low
headache 10 5.00 Very Low Very Low Very Low
aspirin 6 5.00 Very Low Very Low Very Low
Paracetamol 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
complementary and alternative medicine 3 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 58 99.96 Very High Very High Very High
Hematological Disease 6 99.68 Very High Very High Very High
Apoptosis 68 98.64 Very High Very High Very High
Phototoxic Dermatitis 3 98.16 Very High Very High Very High
Cardiovascular Disorder Under Development 5 97.76 Very High Very High Very High
Chronic Lymphoid Leukemia 3 97.64 Very High Very High Very High
Breast Cancer 116 97.52 Very High Very High Very High
Acute Myeloid Leukemia 48 95.94 Very High Very High Very High
Toxicity 30 95.40 Very High Very High Very High
Cancer 105 95.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
cannot compensate for the loss of topoisomerase II?
Negative_regulation (loss) of topoisomerase
1) Confidence 0.42 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647315 Disease Relevance 0 Pain Relevance 0
Finally, compounds within this group enhance DNA cleavage when added to the protein–DNA complex, but display the distinguishing feature of inhibiting topoisomerase II activity when incubated with the enzyme prior to the addition of DNA (89,91,94,97–99).


Negative_regulation (inhibiting) of topoisomerase in cleavage
2) Confidence 0.42 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647315 Disease Relevance 0.15 Pain Relevance 0
This short-term uptake leads to drug localization in cytoplasmic and membrane sites prior to nuclear accumulation and daunomycin topoisomerase inhibition.
Negative_regulation (inhibition) of topoisomerase
3) Confidence 0.27 Published 1998 Journal Lasers Surg Med Section Abstract Doc Link 9694148 Disease Relevance 0.77 Pain Relevance 0.08
C1311 is an inhibitor of topoisomerase II whose design was based upon mitoxantrone but with less cardiotoxicity.
Negative_regulation (inhibitor) of topoisomerase II associated with cardiovascular disorder under development
4) Confidence 0.05 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2579406 Disease Relevance 1.58 Pain Relevance 0.03
It intercalates between DNA base pairs, induces DNA strand breaks, and inhibits DNA biosynthesis and topoisomerase II activity [38].
Negative_regulation (inhibits) of topoisomerase II
5) Confidence 0.02 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2730474 Disease Relevance 1.50 Pain Relevance 0.03
It causing DNA and chromosomal damage found in leukemia, inhibits topo-isomerase II, and alters hematopoiesis and clonal selection [10-14].
Negative_regulation (inhibits) of topo-isomerase II associated with hematological disease and leukemia
6) Confidence 0.02 Published 2006 Journal J Occup Med Toxicol Section Body Doc Link PMC1544343 Disease Relevance 0.87 Pain Relevance 0
Although there in no epidemiological evidence of relation between X-ray developer, fixer and replenisher liquids and AML, these included glutaraldehyde which has weakly associated with lymphocytic leukemia in rats and hydroquinone has been increasingly implicated in producing leukemia, causing DNA and chromosomal damage, inhibits topo-isomerase II, alter hematopoiesis and inhibit apoptosis of neoplastic cells.


Negative_regulation (inhibits) of topo-isomerase II associated with chronic lymphoid leukemia, hematological disease, leukemia, acute myeloid leukemia and apoptosis
7) Confidence 0.02 Published 2006 Journal J Occup Med Toxicol Section Abstract Doc Link PMC1544343 Disease Relevance 1.02 Pain Relevance 0
The structure of the DNA complex with 43 is consistent with the criteria for minor-groove binding with the quinoline rings preferring the A·T sites of the helix and with the positive charge contributed by the metal ion.(170) Interestingly, no inhibition of topoisomerase I activity was observed with the Re complex of 43.(170)
Negative_regulation (inhibition) of topoisomerase in groove
8) Confidence 0.01 Published 2010 Journal Journal of Medicinal Chemistry Section Body Doc Link PMC3018145 Disease Relevance 0.31 Pain Relevance 0

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