INT76757

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Context Info
Confidence 0.59
First Reported 1998
Last Reported 2005
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.19
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SERPINA6) extracellular space (SERPINA6) extracellular region (SERPINA6)
Anatomy Link Frequency
fat 1
SERPINA6 (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 11 100.00 Very High Very High Very High
Pain 39 99.60 Very High Very High Very High
anticonvulsant 4 98.36 Very High Very High Very High
dexamethasone 4 97.28 Very High Very High Very High
gABA 1 87.76 High High
carbamazepine 1 86.24 High High
Inflammation 17 82.80 Quite High
Lasting pain 1 76.44 Quite High
medulla 7 68.60 Quite High
Catecholamine 3 56.32 Quite High
Disease Link Frequency Relevance Heat
Pain 37 99.60 Very High Very High Very High
Adrenal Insufficiency 6 98.44 Very High Very High Very High
Syndrome 3 96.44 Very High Very High Very High
Burns 1 91.32 High High
Injury 1 90.92 High High
Sepsis 33 90.24 High High
INFLAMMATION 19 82.80 Quite High
Affective Disorder 1 77.80 Quite High
Epilepsy 1 75.88 Quite High
Necrosis 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, patients investigated for Cushing's syndrome may show a falsely positive dexamethasone suppression test, and patients with adrenal insufficiency on steroid replacement may require increased doses of steroids; furthermore, increased corticosteroid-binding-globulin levels are also associated with chronic anticonvulsant administration.
Positive_regulation (increased) of corticosteroid-binding-globulin associated with corticosteroid, syndrome, adrenal insufficiency, anticonvulsant and dexamethasone
1) Confidence 0.59 Published 1998 Journal Horm. Metab. Res. Section Abstract Doc Link 9694568 Disease Relevance 0.50 Pain Relevance 0.54
In addition, reports in burned patients have shown that low-fat diet was associated with a significant increase in serum CBG concentrations, suggesting that dietary manipulations may modulate circulating CBG levels [46].
Positive_regulation (increase) of CBG in fat
2) Confidence 0.14 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.43 Pain Relevance 0.12
The trial is the largest RCT examining the effectiveness of corticosteroid for heel pain to date.
Spec (examining) Positive_regulation (effectiveness) of corticosteroid associated with pain and corticosteroid
3) Confidence 0.05 Published 2005 Journal BMC Health Serv Res Section Body Doc Link PMC1112594 Disease Relevance 0.26 Pain Relevance 0.31

General Comments

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