INT76758

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Context Info
Confidence 0.35
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 6.29
Pain Relevance 3.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (RFFL) ligase activity (RFFL) cytoplasm (RFFL)
Anatomy Link Frequency
B-cell 2
cleavage 2
RFFL (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 24 99.78 Very High Very High Very High
diclofenac 18 99.68 Very High Very High Very High
acular 2 99.54 Very High Very High Very High
Morphine 1 94.40 High High
cINOD 16 94.36 High High
dexamethasone 63 92.36 High High
Pain 5 90.48 High High
Inflammation 5 90.12 High High
COX-2 inhibitor 2 83.40 Quite High
Glutamate receptor 1 76.96 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 104 100.00 Very High Very High Very High
Chronic Lymphoid Leukemia 2 99.56 Very High Very High Very High
Stress 20 99.52 Very High Very High Very High
INFLAMMATION 8 95.32 Very High Very High Very High
Glioblastoma 47 94.16 High High
Pain 5 90.48 High High
Drug Induced Neurotoxicity 1 88.40 High High
Squamous Cell Carcinoma 3 85.68 High High
Cancer 14 85.24 High High
Death 16 82.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Diclofenac suppressed the activation of caspases induced by both ER stresses.
Positive_regulation (activation) of Positive_regulation (induced) of caspases associated with stress and diclofenac
1) Confidence 0.35 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16388830 Disease Relevance 1.69 Pain Relevance 0.74
Diclofenac suppressed the activation of caspases induced by both ER stresses.
Positive_regulation (induced) of Positive_regulation (activation) of caspases associated with stress and diclofenac
2) Confidence 0.35 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16388830 Disease Relevance 1.69 Pain Relevance 0.74
Data of Western blot further demonstrated that aspirin treatment caused activation of caspases, down-regulation of Mcl-1 protein, dephosphorylation of ERK-1/2 and AKT, and also IkappaB-alpha proteolysis-dependent NF-kappaB activation in YD-8 cells.
Positive_regulation (caused) of Positive_regulation (activation) of caspases associated with aspirin
3) Confidence 0.02 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 20116423 Disease Relevance 0.63 Pain Relevance 0.62
Aspirin and salicylate induce apoptosis and activation of caspases in B-cell chronic lymphocytic leukemia cells.
Positive_regulation (induce) of Positive_regulation (activation) of caspases in B-cell associated with chronic lymphoid leukemia, aspirin and apoptosis
4) Confidence 0.01 Published 1998 Journal Blood Section Title Doc Link 9694730 Disease Relevance 0.44 Pain Relevance 0.68
Execution of cells by apoptosis usually requires the activation of cysteine proteases such as calpains and caspases [6].
Positive_regulation (requires) of Positive_regulation (activation) of caspases associated with apoptosis
5) Confidence 0.01 Published 2004 Journal Mol Cancer Section Body Doc Link PMC544397 Disease Relevance 1.17 Pain Relevance 0.39
Early activation of caspases involved in the mitochondrial apoptotic pathway was observed, culminating in caspase 3 activation, Poly-ADP Ribose Polymerase (PARP) cleavage and DNA fragmentation.
Positive_regulation (culminating) of Positive_regulation (activation) of caspases in cleavage associated with apoptosis
6) Confidence 0.00 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17250679 Disease Relevance 0.67 Pain Relevance 0.17

General Comments

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