INT76759

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Context Info
Confidence 0.35
First Reported 1998
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 31
Total Number 33
Disease Relevance 29.15
Pain Relevance 9.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (RFFL) ligase activity (RFFL) cytoplasm (RFFL)
Anatomy Link Frequency
cleavage 3
SH-SY5Y 1
neurons 1
B-cell 1
oligodendrocytes 1
RFFL (Homo sapiens)
Pain Link Frequency Relevance Heat
Eae 3 99.84 Very High Very High Very High
diclofenac 27 99.68 Very High Very High Very High
aspirin 58 99.64 Very High Very High Very High
qutenza 11 99.18 Very High Very High Very High
Paracetamol 26 99.12 Very High Very High Very High
acular 4 99.12 Very High Very High Very High
cytokine 1 97.98 Very High Very High Very High
cINOD 42 97.40 Very High Very High Very High
COX-2 inhibitor 7 96.96 Very High Very High Very High
Sciatic nerve 1 96.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 419 99.96 Very High Very High Very High
Stress 47 99.96 Very High Very High Very High
Injury 57 99.84 Very High Very High Very High
Squamous Cell Carcinoma 9 99.70 Very High Very High Very High
Shock 4 99.58 Very High Very High Very High
Chronic Lymphoid Leukemia 5 99.56 Very High Very High Very High
Glioma 6 98.50 Very High Very High Very High
Hepatotoxicity 2 97.84 Very High Very High Very High
Contusions 4 97.72 Very High Very High Very High
Necrosis 7 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Diclofenac inhibited ER-stress-induced apoptosis of SH-SY5Y cells by suppressing the activation of caspases in the intrinsic apoptotic pathway.
Positive_regulation (activation) of caspases in SH-SY5Y associated with stress, apoptosis and diclofenac
1) Confidence 0.35 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16388830 Disease Relevance 1.36 Pain Relevance 0.54
Diclofenac suppressed the activation of caspases induced by both ER stresses.
Positive_regulation (activation) of caspases associated with stress and diclofenac
2) Confidence 0.35 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16388830 Disease Relevance 1.69 Pain Relevance 0.74
Diclofenac suppressed the activation of caspases induced by both ER stresses.
Positive_regulation (induced) of caspases associated with stress and diclofenac
3) Confidence 0.35 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16388830 Disease Relevance 1.63 Pain Relevance 0.69
These results indicated that the synergistic increase in oxidative stress, activation of caspases and DNA fragmentation induced by DOP potentiated the hepatotoxicity of AA.
Positive_regulation (activation) of caspases associated with stress, paracetamol and hepatotoxicity
4) Confidence 0.05 Published 2000 Journal Biol. Pharm. Bull. Section Abstract Doc Link 10784425 Disease Relevance 0.62 Pain Relevance 0.66
Increased DeltaPsim, loss of ATP, and activation of caspases suggests the involvement of intrinsic pathways.


Positive_regulation (activation) of caspases
5) Confidence 0.04 Published 2008 Journal J. Gastroenterol. Section Body Doc Link 18600392 Disease Relevance 0 Pain Relevance 0
Data of Western blot further demonstrated that aspirin treatment caused activation of caspases, down-regulation of Mcl-1 protein, dephosphorylation of ERK-1/2 and AKT, and also IkappaB-alpha proteolysis-dependent NF-kappaB activation in YD-8 cells.
Positive_regulation (activation) of caspases associated with aspirin
6) Confidence 0.04 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 20116423 Disease Relevance 0.63 Pain Relevance 0.62
Aspirin induces apoptosis in YD-8 human oral squamous carcinoma cells through activation of caspases, down-regulation of Mcl-1, and inactivation of ERK-1/2 and AKT.
Positive_regulation (activation) of caspases associated with squamous cell carcinoma, aspirin and apoptosis
7) Confidence 0.04 Published 2010 Journal Toxicol In Vitro Section Title Doc Link 20116423 Disease Relevance 0.67 Pain Relevance 0.68
Activation of the mitochondrial pathway of apoptosis led to the activation of execution caspases-3 and -7.
Positive_regulation (activation) of caspases associated with apoptosis
8) Confidence 0.03 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15665138 Disease Relevance 1.26 Pain Relevance 0.69
These findings collectively suggest that aspirin induces apoptosis in YD-8 cells and the induction may be correlated to activation of caspases, caspase-dependent Mcl-1 proteolysis, inactivation of ERK-1/2 and AKT, and activation of NF-kappaB.
Positive_regulation (activation) of caspases associated with aspirin and apoptosis
9) Confidence 0.02 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 20116423 Disease Relevance 0.60 Pain Relevance 0.57
An important regulatory event in the apoptotic process is the activation of caspases, a family of cysteine proteases, which regulate two major and relatively distinct pathways, the extrinsic and intrinsic pathways.
Positive_regulation (activation) of caspases associated with apoptosis
10) Confidence 0.01 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.69 Pain Relevance 0
At the same time, VNR increased the activity of caspases.
Positive_regulation (increased) of caspases
11) Confidence 0.01 Published 2010 Journal Free Radic. Biol. Med. Section Abstract Doc Link 19837156 Disease Relevance 0.79 Pain Relevance 0.08
We examined the activation of caspases 1, 2, 3, 6, 8, and 9 from 1 hr to 7 days after moderate contusion injury induced by a weight-drop method in the rat.
Spec (examined) Positive_regulation (activation) of caspases associated with injury and contusions
12) Confidence 0.01 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 15795935 Disease Relevance 0.78 Pain Relevance 0.16
Caspases 3, 8, and 9 were activated from 1 to 72 hr after injury, whereas caspases 1, 2, and 6 were not.
Positive_regulation (activated) of Caspases associated with injury
13) Confidence 0.01 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 15795935 Disease Relevance 0.89 Pain Relevance 0.18
Double-label immunohistochemistry utilizing antibodies for CNS cell-type-specific markers and active subunits of caspases 3, 8, or 9 showed that, at 4 and 72 hr after injury, these caspases were primarily activated in neurons and oligodendrocytes, rather than in astrocytes.
Positive_regulation (activated) of caspases in neurons associated with injury
14) Confidence 0.01 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 15795935 Disease Relevance 1.01 Pain Relevance 0.19
Cleavage and activation of caspases is a central event in apoptosis pathways.
Positive_regulation (activation) of caspases in Cleavage associated with apoptosis
15) Confidence 0.01 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.91 Pain Relevance 0
Activation of caspases may occur via different mechanisms [8,9].
Positive_regulation (Activation) of caspases
16) Confidence 0.01 Published 2004 Journal Mol Cancer Section Body Doc Link PMC544397 Disease Relevance 1.29 Pain Relevance 0.35
These results indicate that aspirin and salicylate induce apoptosis of B-CLL cells by activation of caspases and that this activation involves cyclooxygenase-independent mechanisms.
Positive_regulation (activation) of caspases associated with aspirin and apoptosis
17) Confidence 0.01 Published 1998 Journal Blood Section Abstract Doc Link 9694730 Disease Relevance 0.42 Pain Relevance 0.43
Aspirin and salicylate induce apoptosis and activation of caspases in B-cell chronic lymphocytic leukemia cells.
Positive_regulation (activation) of caspases in B-cell associated with chronic lymphoid leukemia, aspirin and apoptosis
18) Confidence 0.01 Published 1998 Journal Blood Section Title Doc Link 9694730 Disease Relevance 0.44 Pain Relevance 0.68
Execution of cells by apoptosis usually requires the activation of cysteine proteases such as calpains and caspases [6].
Positive_regulation (activation) of caspases associated with apoptosis
19) Confidence 0.01 Published 2004 Journal Mol Cancer Section Body Doc Link PMC544397 Disease Relevance 1.16 Pain Relevance 0.38
Early activation of caspases involved in the mitochondrial apoptotic pathway was observed, culminating in caspase 3 activation, Poly-ADP Ribose Polymerase (PARP) cleavage and DNA fragmentation.
Positive_regulation (activation) of caspases in cleavage associated with apoptosis
20) Confidence 0.00 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17250679 Disease Relevance 0.66 Pain Relevance 0.16

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