INT76776

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Context Info
Confidence 0.02
First Reported 1998
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 2.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ptprg) extracellular region (Pnoc)
Anatomy Link Frequency
cerebral cortex 1
Pnoc (Rattus norvegicus)
Ptprg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
orphanin 33 100.00 Very High Very High Very High
Potency 3 100.00 Very High Very High Very High
cerebral cortex 3 99.68 Very High Very High Very High
opioid receptor 13 99.28 Very High Very High Very High
Opioid 7 98.54 Very High Very High Very High
agonist 10 97.20 Very High Very High Very High
Enkephalin 2 92.84 High High
MU agonist 1 91.20 High High
Immobilon 1 70.40 Quite High
antagonist 5 60.64 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The putative coupling of the high-affinity nociceptin receptor to the low-potency stimulation of GTPgammaS binding in rat cerebral cortex might be explained by the switch of a low part of occupied nociceptin binding sites to a very low-affinity state being stabilized at high peptide concentrations and catalytically stimulating the GTP binding.
nociceptin Binding (binding) of GTPgammaS in cerebral cortex associated with orphanin, cerebral cortex and potency
1) Confidence 0.02 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9694948 Disease Relevance 0 Pain Relevance 0.96
The affinity and functional profile of opioids possessing activity at the nociceptin receptor was determined using [3H]nociceptin and nociceptin-stimulated [35S]GTPgammaS binding.
nociceptin Binding (binding) of GTPgammaS associated with orphanin and opioid
2) Confidence 0.00 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10688973 Disease Relevance 0 Pain Relevance 1.32

General Comments

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