INT7678

Context Info Confidence 0.81 First Reported 1981 Last Reported 2011 Negated 1 Speculated 3 Reported most in Abstract Documents 142 Total Number 145 Disease Relevance 80.93 Pain Relevance 22.49

transport (Alb) extracellular space (Alb) extracellular region (Alb) enzyme binding (Alb) DNA binding (Alb) protein complex (Alb)

Anatomy Link Frequency urine 12 hepatocytes 9 blood 8 plasma 5 Heart 2 Alb (Rattus norvegicus)

Pain Link Frequency Relevance Heat Arthritis 87 100.00 alcohol 59 100.00 rheumatoid arthritis 29 100.00 substance P 16 100.00 abdominal pain 3 100.00 halothane 124 99.92 methotrexate 8 99.84 transdermal 4 99.84 ischemia 55 99.80 Analgesic 23 99.68

Disease Link Frequency Relevance Heat Arthritis 80 100.00 Rheumatoid Arthritis 34 100.00 Cyst 6 100.00 Fever 6 100.00 Abdominal Pain 3 100.00 Uveitis 1 100.00 Exanthema 1 100.00 Proteinuria 95 99.96 Diabetes Mellitus 1478 99.84 Hypertension 370 99.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Various functions were measured over 4- and 15-day periods, i.e., albumin secretion rate, deethylation of ethoxyresorufin and phenacetin, dealkylation of pentoxyresorufin, glucuronidation and sulfoconjugation of paracetamol, and N-acetylation of procainamide.

Localization (secretion) of albumin associated with paracetamol

1) Confidence 0.81 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9356313 Disease Relevance 0 Pain Relevance 0.09

Albumin was specifically secreted by the submandibular gland in response to clonidine but not to isoproterenol or phenylephrine.

Neg (not) Localization (secreted) of Albumin in submandibular gland associated with clonidine

2) Confidence 0.81 Published 1992 Journal Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. Section Abstract Doc Link 1354132 Disease Relevance 0 Pain Relevance 0.35

The potential effect of opioids on liver parenchymal-type cells, therefore, was studied using cultured albumin-secreting rat hepatoma cells.

Localization (secreting) of albumin in liver associated with hepatocellular cancer and opioid

3) Confidence 0.81 Published 1984 Journal Exp. Cell Biol. Section Abstract Doc Link 6489584 Disease Relevance 0.25 Pain Relevance 0.75

This revealed a bilateral increase in leucocyte-endothelial adhesion and vascular permeability to albumin after unilateral subtotal ischaemia and muscle stimulation, associated with increased urinary albumin excretion.

Localization (excretion) of albumin in muscle associated with cv unclassified under development and adhesions

4) Confidence 0.81 Published 1993 Journal Br J Surg Section Abstract Doc Link 8443644 Disease Relevance 0.64 Pain Relevance 0.24

The present study was designed to evaluate the urinary albumin excretion in 62 patients with essential hypertension.

Localization (excretion) of albumin associated with hypertension

5) Confidence 0.78 Published 1994 Journal Rom J Intern Med Section Abstract Doc Link 8081306 Disease Relevance 0.80 Pain Relevance 0

The urinary albumin excretion was significantly higher (p < 0.001) in the group of hypertensive patients (19.22 +/- 2.36 micrograms/min) compared to a group of 20 control subjects (4.17 +/- 0.67 microgram/min).

Localization (excretion) of albumin associated with hypertension

6) Confidence 0.78 Published 1994 Journal Rom J Intern Med Section Abstract Doc Link 8081306 Disease Relevance 1.14 Pain Relevance 0.12

However, transient exercise-induced muscle ischaemia results in systemic vascular endothelial injury associated with increased vascular permeability manifest as an increase in urinary albumin excretion.

Localization (excretion) of albumin in muscle associated with injury, cv unclassified under development and edema

7) Confidence 0.78 Published 1994 Journal Eur J Vasc Surg Section Abstract Doc Link 8181617 Disease Relevance 0.80 Pain Relevance 0.09

Urinary albumin excretion was measured in a random urine specimen.

Localization (excretion) of albumin in urine

8) Confidence 0.78 Published 2005 Journal Int. J. Cardiol. Section Body Doc Link 16243103 Disease Relevance 0.09 Pain Relevance 0

Median urinary excretion of albumin was 9 (range 1-206) mg 24-h-1 in patients with Type 1 diabetes and 7 (1-90) mg 24-h-1 in patients with secondary diabetes (NS).

Localization (excretion) of albumin associated with diabetes mellitus

9) Confidence 0.78 Published 1990 Journal Diabet. Med. Section Abstract Doc Link 2148135 Disease Relevance 1.96 Pain Relevance 0.14

Creatinine clearance, urinary micro albumin excretion and (NAG) levels were comparable in both the groups.

Localization (excretion) of albumin associated with disorders of creatine metabolism

10) Confidence 0.78 Published 2009 Journal Semin Cardiothorac Vasc Anesth Section Abstract Doc Link 19948518 Disease Relevance 0.19 Pain Relevance 0.30

To assess its usefulness in older patients with systolic hypertension and widened pulse pressure, we compared the effects of eplerenone with amlodipine, on clinic blood pressure (BP) and pulse pressure and in a subset of the patients, ambulatory BP, vascular compliance, and urinary albumin excretion.

Localization (excretion) of albumin in blood associated with hypertension

11) Confidence 0.78 Published 2003 Journal Hypertension Section Abstract Doc Link 12682082 Disease Relevance 0.35 Pain Relevance 0.04

We found that by 1 month, necrosis of the papilla was complete, glomerular filtration rate was depressed, and urine albumin excretion was increased.

Localization (excretion) of albumin in urine associated with necrosis

12) Confidence 0.76 Published 1999 Journal Am. J. Kidney Dis. Section Abstract Doc Link 10352190 Disease Relevance 0.95 Pain Relevance 0.17

In conclusion, degeneration of thin afferent fibers may alter the autonomic reflex response to intra-abdominal trauma, but neuropeptide release from afferents apparently plays no role in the relocation of albumin.

Localization (relocation) of albumin in autonomic associated with injury and neuropeptide release

13) Confidence 0.75 Published 1992 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 1595342 Disease Relevance 0.55 Pain Relevance 0.29

Rats subjected to nerve lesion showed pronounced activation of GFAP indicating astrocyte activation, and exhibited marked leakage of albumin, suggesting defects of the blood-spinal cord barrier (BSCB) function in the corresponding spinal cord segment.

Localization (leakage) of albumin in spinal cord segment associated with spinal cord

14) Confidence 0.75 Published 2006 Journal Pain Section Abstract Doc Link 16806707 Disease Relevance 0.09 Pain Relevance 0.30

Serum albumin concentration was time-dependently decreased and correlated well with 3 major biologic determinants of drug clearance, hepatic blood flow (HBF), intrinsic clearance (CL(int)), and the unbound fraction of drugs in plasma (fp) after intravenous administration of cyclophosphamide, tolbutamide, zonisamide, and chlorzoxazone (as probe drugs for low hepatic extraction) and propranolol and lidocaine (as high-hepatic extraction drugs).

Localization (decreased) of Serum albumin in plasma associated with lidocaine

15) Confidence 0.74 Published 2006 Journal Biol. Pharm. Bull. Section Abstract Doc Link 16880627 Disease Relevance 0.26 Pain Relevance 0.09

The findings do not support a role for the enteric nervous system for the egg albumin induced changes in Cl- secretion.

Localization (secretion) of albumin in egg

16) Confidence 0.74 Published 1989 Journal Agents Actions Section Abstract Doc Link 2512772 Disease Relevance 0.48 Pain Relevance 0.23

Since cardiac ischaemia and sympathetic stimulation are strong stimuli for the release of atrial natriuretic peptide (ANP), we examined if ANP (0.25, 0.50, and 1.00 microg kg(-1) min(-1), n = 8 per dose) affects urinary albumin excretion.

Localization (excretion) of albumin in sympathetic associated with natriuresis and ischemic heart disease

17) Confidence 0.74 Published 1997 Journal Acta Physiol. Scand. Section Abstract Doc Link 9338510 Disease Relevance 1.16 Pain Relevance 0.11

These animals showed a transient increase in urine flow rate, sodium and albumin excretion with maximum 30-60 min after resuscitation, while GFR and lithium clearance were normal.

Localization (excretion) of albumin in urine

18) Confidence 0.74 Published 1997 Journal Acta Physiol. Scand. Section Abstract Doc Link 9338510 Disease Relevance 1.06 Pain Relevance 0.13

We studied rat aortic endothelial and smooth muscle cell de novo histamine synthesis mediated by histidine decarboxylase (HD) and the effects of its inhibition by alpha-hydrazinohistidine on the intracellular histamine content and intraaortic albumin accumulation in streptozotocin-induced diabetes.

Localization (accumulation) of albumin in smooth muscle cell associated with diabetes mellitus

19) Confidence 0.74 Published 1983 Journal Arteriosclerosis Section Abstract Doc Link 6651615 Disease Relevance 0.61 Pain Relevance 0.09

Urinary albumin excretion rates, expressed as albumin-creatinine ratios (ACR, mg/mmol) were measured before and after exercise in 23 claudicants and 10 controls.

Localization (excretion) of albumin

20) Confidence 0.73 Published 1990 Journal Eur J Vasc Surg Section Abstract Doc Link 2279570 Disease Relevance 0.14 Pain Relevance 0.07

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