INT7680

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Context Info
Confidence 0.45
First Reported 1988
Last Reported 2010
Negated 8
Speculated 2
Reported most in Abstract
Documents 27
Total Number 31
Disease Relevance 4.52
Pain Relevance 18.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Drd1a) plasma membrane (Drd1a) nucleus (Drd1a)
intracellular (Drd1a) signal transducer activity (Drd1a)
Anatomy Link Frequency
neurons 5
cerebellum 2
shell 1
striatum 1
brain 1
Drd1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 349 100.00 Very High Very High Very High
agonist 101 100.00 Very High Very High Very High
dopamine receptor 77 100.00 Very High Very High Very High
antagonist 63 100.00 Very High Very High Very High
opioid receptor 11 100.00 Very High Very High Very High
Enkephalin 24 99.96 Very High Very High Very High
Neuropeptide 10 99.80 Very High Very High Very High
anesthesia 6 99.32 Very High Very High Very High
Morphine 46 99.30 Very High Very High Very High
Opioid 13 99.26 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 270 99.82 Very High Very High Very High
Disease 66 97.76 Very High Very High Very High
Hypertension 27 95.52 Very High Very High Very High
Drug Dependence 8 93.72 High High
Paralysis 2 90.32 High High
Diuresis 5 86.16 High High
Shock 12 86.12 High High
Natriuresis 6 85.64 High High
Stress 38 84.00 Quite High
Cognitive Disorder 39 76.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The specific D1 dopamine-receptor antagonist SCH 23390 (0.05 mg/kg SC), paired with both compartments or, separately, with the preferred or with the non-preferred compartment, failed to affect the spontaneous unconditioned preference of the animal.
Neg (failed) Regulation (affect) of D1 dopamine-receptor associated with dopamine and antagonist
1) Confidence 0.45 Published 1989 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 2572027 Disease Relevance 0 Pain Relevance 0.65
The involvement of dopamine D1 receptor systems in the reinforcing properties of opiate reward was studied by examining the effect of the dopamine D1 antagonist SCH23390 on the initiation of heroin self-administration in rats.
Spec (examining) Regulation (effect) of dopamine D1 associated with dopamine, antagonist and opiate
2) Confidence 0.45 Published 1994 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7855207 Disease Relevance 0 Pain Relevance 0.49
Moreover, long term administration of both imipramine or SKF 38393 down regulated D1 dopamine receptor number in the prefrontal cortex, while the association of the two drugs resulted in a receptor density similar to that of control rats. 3.
Regulation (regulated) of D1 dopamine receptor in prefrontal associated with dopamine receptor
3) Confidence 0.45 Published 1995 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 8539417 Disease Relevance 0.23 Pain Relevance 0.49
Addition of the dopamine-2 antagonist YM-09151 to the dopamine-1 antagonist infusion did not enhance the effect of the dopamine-1 antagonist.
Regulation (effect) of dopamine-1 associated with dopamine and antagonist
4) Confidence 0.45 Published 1990 Journal Hypertension Section Abstract Doc Link 1971811 Disease Relevance 0.94 Pain Relevance 0.99
Effects of the novel D1 dopamine receptor agonist ABT-431 on cocaine self-administration and reinstatement.
Regulation (Effects) of D1 dopamine receptor associated with dopamine receptor, agonist and cocaine
5) Confidence 0.43 Published 2000 Journal Ann. N. Y. Acad. Sci. Section Title Doc Link 10911927 Disease Relevance 0.09 Pain Relevance 0.77
The effects of the novel and selective dopamine D-1 agonist CY 208-243 on the rat hypothalamo-hypophyseal-gonadal (HHG) axis were studied.
Regulation (effects) of dopamine D-1 in HHG associated with dopamine and agonist
6) Confidence 0.40 Published 1988 Journal Experientia Section Abstract Doc Link 3416994 Disease Relevance 0 Pain Relevance 0.26
D1 receptor antagonist SCH 23390 [R-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3- benzazepin-7-ol hemimaleate] at 0.01 mg/kg did not affect quinpirole-induced yawning or its inhibition by morphine.
Neg (not) Regulation (affect) of D1 receptor associated with antagonist and morphine
7) Confidence 0.39 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8100615 Disease Relevance 0 Pain Relevance 1.29
Since activation of glucocorticoid receptors by corticosterone did not affect D-1 receptor functioning in cultured neurons of saline-pretreated rats, prior intermittent exposure to morphine (somehow) appears to induce a long-lasting state of corticosterone hyperresponsiveness in striatal neurons.
Neg (not) Regulation (affect) of D-1 receptor in neurons associated with morphine
8) Confidence 0.38 Published 1996 Journal Neurochem. Res. Section Abstract Doc Link 8947932 Disease Relevance 0 Pain Relevance 0.95
The effects of dopamine D-1 and D-2 receptor subtype agonists on nigrostriatal opioid dynorphin and enkephalin immunostaining in 6-hydroxydopamine lesioned rats.
Regulation (effects) of dopamine D-1 associated with dopamine, dynorphin, agonist, enkephalin and opioid
9) Confidence 0.37 Published 1991 Journal Chin J Physiol Section Title Doc Link 1687937 Disease Relevance 0 Pain Relevance 1.00
Treatment of primary neuronal cultures of the rat striatal complex (striatum/nucleus accumbens, consisting for more than 90% of gamma-aminobutyric acid neurons) with 10 microM morphine for 2 hr to 3 days, enhanced the maximal stimulatory effect of the dopamine D-1 receptor agonist SKF38393 on adenylyl cyclase activity.
Regulation (effect) of D-1 receptor in neurons associated with nucleus accumbens, dopamine, agonist and morphine
10) Confidence 0.36 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7562482 Disease Relevance 0 Pain Relevance 0.68
The lack of correlation between the terminal/receptor distribution patterns suggests a role for volume transmission for mu-opioid receptor- and dopamine D1 receptor-mediated transmission in distinct regions of the amygdala and extended amygdala.
Regulation (role) of dopamine D1 in amygdala associated with dopamine, opioid receptor and amygdala
11) Confidence 0.35 Published 2006 Journal Neuroscience Section Abstract Doc Link 16820264 Disease Relevance 0 Pain Relevance 1.03
The present study examined the involvement of dopamine D1 and neuropeptide Y Y1 receptors in the conditioned immunomodulatory effects of morphine.
Spec (examined) Regulation (involvement) of dopamine D1 associated with dopamine, neuropeptide and morphine
12) Confidence 0.33 Published 2008 Journal Brain Behav. Immun. Section Abstract Doc Link 17689049 Disease Relevance 0 Pain Relevance 0.78
The effects of the dopamine D1 antagonist SCH23390 and the D2 antagonist raclopride were studied in Experiment 3.
Regulation (effects) of dopamine D1 associated with dopamine and antagonist
13) Confidence 0.33 Published 1993 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 8255911 Disease Relevance 0 Pain Relevance 0.65
Because of the theoretical importance of such an interaction with respect to understanding the normal physiology of dopaminergic systems, we evaluated effects of D-1 and D-2 selective agonists, applied microiontophoretically, on the spontaneous electrical activity of a single, identifiable subpopulation of neurons within the caudate nucleus, the type I striatal neuron, in locally anesthetized, gallamine-paralyzed rats.
Regulation (effects) of D-1 in neuron associated with agonist and paralysis
14) Confidence 0.32 Published 1992 Journal Synapse Section Abstract Doc Link 1354398 Disease Relevance 0.09 Pain Relevance 0.24
Microiontophoretic studies of the effects of D-1 and D-2 receptor agonists on type I caudate nucleus neurons: lack of synergistic interaction.
Regulation (effects) of D-1 in neurons associated with anesthesia and agonist
15) Confidence 0.32 Published 1992 Journal Synapse Section Title Doc Link 1354398 Disease Relevance 0.07 Pain Relevance 0.37
Whereas exposure of these neurons to 10 microM morphine for 7 days caused a profound increase in cyclic AMP production, induced by the dopamine D1 receptor agonist SKF 38393 (1 microM), Scatchard analysis of [125I]SCH 23982 binding to membrane preparations revealed that neither the Bmax nor the Kd values of dopamine D1 receptor binding sites were affected.
Neg (neither) Regulation (affected) of D1 receptor in neurons associated with dopamine, agonist and morphine
16) Confidence 0.31 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8386668 Disease Relevance 0.07 Pain Relevance 0.62
In cerebellum dopamine D1 receptor was down regulated and D2 receptor showed an up regulation.
Regulation (regulated) of dopamine D1 receptor in cerebellum associated with dopamine
17) Confidence 0.31 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2890658 Disease Relevance 0.79 Pain Relevance 0.46
It is concluded that chronic morphine treatment probably induces a down regulation of nigral D-1 and D-2 binding sites and reduces the negative feed-back mechanisms triggered by DA autoreceptors.
Regulation (regulation) of D-1 associated with dopamine and morphine
18) Confidence 0.23 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2456939 Disease Relevance 0 Pain Relevance 0.90
The D1 dopamine receptor (D1R) mRNA level was not significantly modified after either treatment.
Neg (not) Regulation (modified) of D1 dopamine receptor associated with dopamine receptor
19) Confidence 0.19 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7518029 Disease Relevance 0 Pain Relevance 0.37
The affinity for several other rat brain receptors such as 5-HT1A, alpha 2-adrenergic, dopamine D1, muscarinic M1 and M2, opiate sigma and beta 2-adrenergic was low.
Regulation (affinity) of dopamine D1 in brain associated with dopamine and opiate
20) Confidence 0.18 Published 1990 Journal Pharmacol. Toxicol. Section Abstract Doc Link 2154737 Disease Relevance 0 Pain Relevance 0.29

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