INT76807

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Context Info
Confidence 0.36
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.54
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (MCC) plasma membrane (MCC) nucleus (MCC)
cytoplasm (MCC)
Anatomy Link Frequency
muscle 1
MCC (Homo sapiens)
MCC - Q67L (1)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 8 100.00 Very High Very High Very High
Pain 7 99.36 Very High Very High Very High
opioid receptor 4 96.16 Very High Very High Very High
Enkephalin 2 62.84 Quite High
imagery 5 5.00 Very Low Very Low Very Low
Congenital analgesia 1 5.00 Very Low Very Low Very Low
Nerve growth factor 1 5.00 Very Low Very Low Very Low
Peripheral nervous system 1 5.00 Very Low Very Low Very Low
Demyelination 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myalgia 3 99.48 Very High Very High Very High
Disease 77 96.62 Very High Very High Very High
Malaria 39 50.00 Quite Low
Cerebral Malaria 21 17.20 Low Low
Motor Neuron Diseases 1 8.64 Low Low
Anaemia 9 5.00 Very Low Very Low Very Low
Charcot Marie Tooth Disease 6 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Infection 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Methylcrotonyl-CoA carboxylase (MCC) deficiency associated with severe muscle pain and physical disability in an adult.
MCC Binding (associated) of in muscle associated with pain and myalgia
1) Confidence 0.36 Published 2005 Journal J. Inherit. Metab. Dis. Section Title Doc Link 16435208 Disease Relevance 0.19 Pain Relevance 0.38
Conditional logistic regression based on matched pairs and adjusted for ethnic groups was carried out for each single locus (Sl and McC) and for the combination of the two loci.
McC Binding (combination) of
2) Confidence 0.10 Published 2005 Journal Malar J Section Body Doc Link PMC1308855 Disease Relevance 0 Pain Relevance 0
Specifically, we demonstrate significantly increased interaction of both Rab7 disease mutants with ORP1L, a well-characterized effector of active Rab7 that facilitates retrograde trafficking of late endosomes (36), and Vps13C, which also shows increased binding to the Q67L mutant and is likely a mediator of active Rab7 function.
Q67L mutant (Q67L) Binding (binding) of associated with disease
3) Confidence 0.01 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.35 Pain Relevance 0
The mutant receptor, kappa (E297K + Y313H + Y312W + S310V), in which the Glu297, Ser310, Tyr312 and Tyr313 of kappa-opioid receptor were changed to Lys, Val, Trp and His, respectively, bound to DAMGO with high affinity (Kd = 8.7 +/- 1.2 nM) and efficiently mediated the inhibitory effect of DAMGO on intracellular cAMP accumulation.
mutant receptor Binding (bound) of associated with kappa opioid receptor
4) Confidence 0.00 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9696421 Disease Relevance 0 Pain Relevance 0.54

General Comments

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