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Context Info
Confidence 0.00
First Reported 1998
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.54

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signal transduction (MCC) plasma membrane (MCC) nucleus (MCC)
cytoplasm (MCC)
MCC (Homo sapiens)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 8 100.00 Very High Very High Very High
opioid receptor 4 96.16 Very High Very High Very High
Enkephalin 2 62.84 Quite High


Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mutant receptor, kappa (E297K + Y313H + Y312W + S310V), in which the Glu297, Ser310, Tyr312 and Tyr313 of kappa-opioid receptor were changed to Lys, Val, Trp and His, respectively, bound to DAMGO with high affinity (Kd = 8.7 +/- 1.2 nM) and efficiently mediated the inhibitory effect of DAMGO on intracellular cAMP accumulation.
Transcription (changed) of mutant receptor associated with kappa opioid receptor
1) Confidence 0.00 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9696421 Disease Relevance 0 Pain Relevance 0.54

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