INT76813

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Context Info
Confidence 0.75
First Reported 1998
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 20
Total Number 22
Disease Relevance 10.96
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Hgf) extracellular space (Hgf) cell morphogenesis (Hgf)
Anatomy Link Frequency
HGF 13
neuronal 3
hepatocyte 2
liver 1
muscle 1
Hgf (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 4 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 1 100.00 Very High Very High Very High
Spinal cord 23 99.68 Very High Very High Very High
allodynia 5 96.04 Very High Very High Very High
chemokine 116 95.64 Very High Very High Very High
intrathecal 10 95.26 Very High Very High Very High
withdrawal 1 93.60 High High
antagonist 6 93.12 High High
Sciatic nerve 3 92.36 High High
Pain 1 87.04 High High
Disease Link Frequency Relevance Heat
Motor Neuron Diseases 396 99.76 Very High Very High Very High
Cancer 2238 99.72 Very High Very High Very High
Adhesions 7 99.50 Very High Very High Very High
Nervous System Injury 8 99.18 Very High Very High Very High
Adenocarcinoma 23 98.48 Very High Very High Very High
Neuropathic Pain 7 96.04 Very High Very High Very High
Injury 102 93.60 High High
Pain 3 87.04 High High
Breast Cancer 90 85.84 High High
INFLAMMATION 45 80.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have also found components of a regulatory network consisting of FOXF1, vascular cell adhesion molecule-1 (VCAM1), and hepatocyte growth factor (HGF) selectively expressed in colon and urinary tract SMCs (Figure 4D).
Gene_expression (expressed) of hepatocyte growth factor in hepatocyte associated with adhesions
1) Confidence 0.75 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.15 Pain Relevance 0
Accordingly, hepatic overexpression of HGF remarkably accelerated whereas loss of c-Met signaling decreased regenerative potential of liver [7]–[10].
Gene_expression (overexpression) of HGF in liver
2) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0.27 Pain Relevance 0.03
We also used immunocytochemistry to analyze nerve injury-induced changes in substance P (SP) and NK-1 (SP) receptor expression in the spinal cord.
Gene_expression (expression) of NK-1 in nerve associated with nervous system injury, spinal cord and substance p
3) Confidence 0.58 Published 1998 Journal Pain Section Abstract Doc Link 9696476 Disease Relevance 1.28 Pain Relevance 1.05
On the other hand, the expression of bFGF, HGF or IGF was not affected in this study.
Gene_expression (expression) of HGF in HGF
4) Confidence 0.50 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2955572 Disease Relevance 0.06 Pain Relevance 0.04
We next examined the synthesis of basic FGF, HGF and IGF in ischemic muscle after cell transplantation by real-time PCR.
Spec (examined) Gene_expression (synthesis) of HGF in muscle
5) Confidence 0.50 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2955572 Disease Relevance 0 Pain Relevance 0
Several putative functions for PCI in the developing mouse lung can be postulated: (1) PCI is directly involved in lung morphogenesis participating in branching of the bronchiolar tree by controlling extracellular proteolysis; (2) PCI is secreted into amniotic fluid and the lung may represent a source of PCI production and secretion into the amniotic fluid; (3) PCI could act through interaction with HGF which is expressed in lung mesenchyme (Sonnenberg et al. 1993); (4) notably, PCI expression could not be detected in the epithelia responsible for gas exchange in sacculi and alveoli at later stages of development.
Gene_expression (expressed) of HGF in lung
6) Confidence 0.44 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0.15 Pain Relevance 0
HGF also has the ability to transactivate the EGF receptor to induce motility [54] and reciprocally, EGF is able to stimulate HGF production [52].
Gene_expression (production) of HGF in HGF
7) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.45 Pain Relevance 0
The presence of HGF and EGF in vivo (Figure 3D and 3E), may have an impact on growth later phase growth (past day 8) or likewise in other tumor models.
Gene_expression (presence) of HGF in HGF associated with cancer
8) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.86 Pain Relevance 0
The HGF, bFGF, TGF-?
Gene_expression (The) of HGF in HGF
9) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.37 Pain Relevance 0
Several adenocarcinoma tumor-microenvironment crosstalk models implicate growth factors including HGF, [49] VEGF, [50] TGF-?
Gene_expression ([49) of HGF in HGF associated with adenocarcinoma and cancer
10) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.57 Pain Relevance 0
The presence of MSC within the tumor also enhanced expression of growth factors such as EGF and HGF.
Gene_expression (expression) of HGF in HGF associated with cancer
11) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 1.32 Pain Relevance 0
MSC co-cultured with Skov-3 cells of Skov-3 CM secrete growth factors such as HGF, IL-6, TGF-?
Gene_expression (cultured) of HGF in HGF
12) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.50 Pain Relevance 0
For instance, hepatocyte growth factor (HGF)-mediated Cxcl1/KC production has been shown to influence the normal effects of HGF on epithelial morphogenesis, suggesting that Cxcl1/KC can act in an autocrine fashion in these cells, thereby playing a beneficial role in the repair process as well (42).
Gene_expression (production) of HGF in hepatocyte
13) Confidence 0.33 Published 2010 Journal International Immunology Section Body Doc Link PMC2877810 Disease Relevance 0.30 Pain Relevance 0.37
induces HGF expression by fibroblasts [47] but also induces the transition of fibroblasts to myofibroblasts by increasing ?
Gene_expression (expression) of HGF in HGF
14) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.70 Pain Relevance 0
On the basis of our in vitro tumor growth assay data, we conclude that the MSC produced paracrine factors HGF, FGF, TGF-?
Gene_expression (produced) of HGF in HGF associated with cancer
15) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.61 Pain Relevance 0
Skov-3 cells and MSC interact in a paracrine manner by inducing reciprocal growth factor expression including IL-6, VEGF, HGF and TGF-?
Gene_expression (expression) of HGF in HGF
16) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.70 Pain Relevance 0
The HGF/c-Met interaction plays a pivotal role in cancer invasion that is mediated by the tumor stromal cell production of HGF [52], which can induce ECM degradation, tubule formation and angiogenesis [53].
Gene_expression (production) of HGF in HGF associated with cancer
17) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.55 Pain Relevance 0
Finally, we considered that InlB might promote Lm invasion by increasing endocytosis of junctional E-cadherin through c-Met activation as shown for HGF action on nonpolarized cells [46], [47].
Gene_expression (action) of HGF in HGF
18) Confidence 0.28 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2869327 Disease Relevance 0.43 Pain Relevance 0
Recombinant human hepatocyte growth factor (rh-HGF) has, in addition to its neurotropic effects, antiapoptotic and antiglutammatergic properties.63,64 Intrathecal aministration and gene therapy significantly prolonged survival in different studies on SOD1 animal models, even if delivered at symptom onset.63–65 A recent immunohistochemical study on both familial (SOD1) and sporadic ALS found that HGF is expressed on the anterior horn cells of the spinal cord, supporting the hypothesis that disruption of HGF system thereby contributes to the acceleration of neuronal degeneration in FALS patients.66
Gene_expression (expressed) of HGF in neuronal associated with motor neuron diseases, spinal cord and intrathecal
19) Confidence 0.26 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2785861 Disease Relevance 0.65 Pain Relevance 0.14
Endoluminal pressure was recorded and the expression of neuronal nitric oxide synthase (nNOS), NK1 and NK2 neurokinin receptors was investigated by immunohistochemistry.
Spec (investigated) Gene_expression (expression) of NK2 in neuronal associated with neuronal nitric oxide synthase
20) Confidence 0.26 Published 2006 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 16918764 Disease Relevance 0 Pain Relevance 0.30

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